ADVANCEMENTS IN BERBERINE-LOADED MICROEMULSION FOR ORAL DELIVERY: A COMPREHENSIVE REVIEW
Main Article Content
Keywords
Berberine, Microemulsion, Oral formulation, Drug delivery, Bioavailability, Pharmacological properties
Abstract
Berberine, a natural alkaloid with a wide range of pharmacological effects, has received a lot of attention due to its possible medicinal benefits. However, its low oral bioavailability and solubility in water pose significant obstacles to achieving effective treatment effects. This review study investigates recent advances in the creation and characterisation of berberine-loaded microemulsion-based oral formulations as a possible approach for improving berberine oral delivery. The scope of this study includes a thorough examination of the literature on the formation of berberine-loaded microemulsions and their prospective applications. The paper examines the principles and benefits of microemulsion as a diverse drug delivery technology, as well as the many formulation factors that are critical in guaranteeing the microemulsion's stability and bioavailability. A search of reliable sources, such as PubMed, Scopus, and Web of Science, yielded research papers, review articles, and patents on the creation of berberine-loaded microemulsions for oral administration. Key findings from the reviewed literature reveal that microemulsion-based formulations offer a promising approach to improve berberine's oral bioavailability and solubility, enhancing its therapeutic efficacy in various medical conditions.
References
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18. Chen, C., Yu, Z., Li, Y., Fichna, J., & Storr, M. (2014, January). Effects of Berberine in the Gastrointestinal Tract — A Review of Actions and Therapeutic Implications. The American Journal of Chinese Medicine, 42(05), 1053–1070. https://doi.org/10.1142/s0192415x14500669
19. Li, W. L., Zheng, H. C., Bukuru, J., & De Kimpe, N. (2004). Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of ethnopharmacology, 92(1), 1-21.
20. Kataoka, M., Tokuyama, E., Miyanaga, Y., & Uchida, T. (2008). The taste sensory evaluation of medicinal plants and Chinese medicines. International journal of pharmaceutics, 351(1-2), 36-44.
21. Fabricant, D. S., & Farnsworth, N. R. (2001). The value of plants used in traditional medicine for drug discovery. Environmental health perspectives, 109(suppl 1), 69-75.
22. José San, M. A. (1983, April). Medicinal plants in Central Chile. Economic Botany, 37(2), 216–227. https://doi.org/10.1007/bf02858788
23. Tang, J., Feng, Y., Tsao, S., Wang, N., Curtain, R., & Wang, Y. (2009). Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. Journal of ethnopharmacology, 126(1), 5-17.
24. Houghton, P. J., & Manby, J. (1985). Medicinal plants of the Mapuche. Journal of Ethnopharmacology, 13(1), 89-103.
25. Anesini, C., & Perez, C. (1993). Screening of plants used in Argentine folk medicine for antimicrobial activity. Journal of ethnopharmacology, 39(2), 119-128.
26. Gibaud, S., & Attivi, D. (2012, June 5). Microemulsions for oral administration and their therapeutic applications. Expert Opinion on Drug Delivery, 9(8), 937–951. https://doi.org/10.1517/17425247.2012.694865
27. Gull, A., Ahmed, S., Ahmad, F. J., Nagaich, U., & Chandra, A. (2020, August). Hydrogel thickened microemulsion; a local cargo for the co- delivery of cinnamaldehyde and berberine to treat acne vulgaris. Journal of Drug Delivery Science and Technology, 58, 101835. https://doi.org/10.1016/j.jddst.2020.101835
28. Elsheikh, M. A., Elnaggar, Y. S., Hamdy, D. A., & Abdallah, O. Y. (2018, January). Novel cremochylomicrons for improved oral bioavailability of the antineoplastic phytomedicine berberine chloride: Optimization and pharmacokinetics. International Journal of Pharmaceutics, 535(1–2), 316–324. https://doi.org/10.1016/j.ijpharm.2017.11.023
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30. Zhu, J. X., Tang, D., Feng, L., Zheng, Z. G., Wang, R. S., Wu, A. G., Duan, T. T., He, B., & Zhu, Q. (2012, May 8). Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride. Drug Development and Industrial Pharmacy, 39(3), 499–506. https://doi.org/10.3109/03639045.2012.683875
31. Gui, Sh & Wu, L & Peng, D.Y. & Liu, Q.Y. & Yin, B.P. & Shen, J.. (2008). Preparation and evaluation of a microemulsion for oral delivery of berberine. Die Pharmazie. 63. 516-9. 10.1691/ph.2008.8018.
2. Su, G., Wang, H., Gao, Y., Chen, G., Pei, Y., & Bai, J. (2017, November 2). 1H-NMR-Based Metabonomics of the Protective Effect of Coptis chinensis and Berberine on Cinnabar-Induced Hepatotoxicity and Nephrotoxicity in Rats. Molecules, 22(11), 1855. https://doi.org/10.3390/molecules22111855
3. Song, D., Hao, J., & Fan, D. (2020, April 25). Biological properties and clinical applications of berberine. Frontiers of Medicine, 14(5), 564–582. https://doi.org/10.1007/s11684-019-0724-6
4. Canny, S. A., Cruz, Y., Southern, M. R., & Griffin, P. R. (2011, November 13). PubChem promiscuity: a web resource for gathering compound promiscuity data from PubChem. Bioinformatics, 28(1), 140–141. https://doi.org/10.1093/bioinformatics/btr622
5. Berberine - an overview | ScienceDirect Topics. (n.d.). Berberine - an Overview | ScienceDirect Topics. https://doi.org/10.1016/B978-0-12-817890-4.00012-3
6. Chen, M., Shen, H., Zhu, L., Yang, H., Ye, P., Liu, P., Gu, Y., & Chen, S. (2019, February 20). Berberine attenuates hypoxia‐induced pulmonary arterial hypertension via bone morphogenetic protein and transforming growth factor‐β signaling. Journal of Cellular Physiology, 234(10), 17482–17493. https://doi.org/10.1002/jcp.28370
7. Crusz, S. M., & Balkwill, F. R. (2015, June 30). Inflammation and cancer: advances and new agents. Nature Reviews Clinical Oncology, 12(10), 584–596. https://doi.org/10.1038/nrclinonc.2015.105
8. Cui, H. X., Hu, Y. N., Li, J. W., Yuan, K., & Guo, Y. (2018, December 28). Preparation and Evaluation of Antidiabetic Agents of Berberine Organic Acid Salts for Enhancing the Bioavailability. Molecules, 24(1), 103. https://doi.org/10.3390/molecules24010103
9. de Ferranti, S. D., Gauvreau, K., Friedman, K. G., Tang, A., Baker, A. L., Fulton, D. R., Tremoulet, A. H., Burns, J. C., & Newburger, J. W. (2018, December 3). Association of Initially Normal Coronary Arteries With Normal Findings on Follow-up Echocardiography in Patients With Kawasaki Disease. JAMA Pediatrics, 172(12), e183310. https://doi.org/10.1001/jamapediatrics.2018.3310
10. Neag, M. A., Mocan, A., Echeverría, J., Pop, R. M., Bocsan, C. I., Crişan, G., & Buzoianu, A. D. (2018, August 21). Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders. Frontiers in Pharmacology, 9. https://doi.org/10.3389/fphar.2018.00557
11. Shabbir, A. (2012, August 22). Berberis lycium Royle: A review of its traditional uses, phytochemistry and pharmacology. African Journal of Pharmacy and Pharmacology, 6(31). https://doi.org/10.5897/ajpp12.927
12. Rahaman, M. (2013, January 10). Rationalization of Traditional Uses of Berberis lycium in Gastrointestinal Disorders. British Journal of Medicine and Medical Research, 3(4), 868–879. https://doi.org/10.9734/bjmmr/2013/2678
13. Affuso, F., Ruvolo, A., Micillo, F., Saccà, L., & Fazio, S. (2010, November). Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study. Nutrition, Metabolism and Cardiovascular Diseases, 20(9), 656–661. https://doi.org/10.1016/j.numecd.2009.05.017
14. SAILOR, G. U., D. RAMANI, V., SHAH, N., PARMAR, G. R., GOHIL, D., BALARAMAN, R., & SETH, A. (2021). Design of Experiment Approach Based Formulation Optimization of Berberine Loaded Solid Lipid Nanoparticle for Antihyperlipidemic Activity. Indian Journal of Pharmaceutical Sciences. https://doi.org/10.36468/pharmaceutical-sciences.766
15. Liggins, R., & Burt, H. (2002, February). Polyether–polyester diblock copolymers for the preparation of paclitaxel loaded polymeric micelle formulations. Advanced Drug Delivery Reviews, 54(2), 191–202. https://doi.org/10.1016/s0169-409x(02)00016-9
16. Kirtikar, K. R., & Basu, B. D. (1918). Indian medicinal plants (Vol. 2). publisher not identified Basu, Bhuwaneśwari Âśrama.
17. Rajasekaran, A., & Kumar, N. (2009). Rasont–A traditional crude drug prepared from Berberis sp and its uses.
18. Chen, C., Yu, Z., Li, Y., Fichna, J., & Storr, M. (2014, January). Effects of Berberine in the Gastrointestinal Tract — A Review of Actions and Therapeutic Implications. The American Journal of Chinese Medicine, 42(05), 1053–1070. https://doi.org/10.1142/s0192415x14500669
19. Li, W. L., Zheng, H. C., Bukuru, J., & De Kimpe, N. (2004). Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of ethnopharmacology, 92(1), 1-21.
20. Kataoka, M., Tokuyama, E., Miyanaga, Y., & Uchida, T. (2008). The taste sensory evaluation of medicinal plants and Chinese medicines. International journal of pharmaceutics, 351(1-2), 36-44.
21. Fabricant, D. S., & Farnsworth, N. R. (2001). The value of plants used in traditional medicine for drug discovery. Environmental health perspectives, 109(suppl 1), 69-75.
22. José San, M. A. (1983, April). Medicinal plants in Central Chile. Economic Botany, 37(2), 216–227. https://doi.org/10.1007/bf02858788
23. Tang, J., Feng, Y., Tsao, S., Wang, N., Curtain, R., & Wang, Y. (2009). Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. Journal of ethnopharmacology, 126(1), 5-17.
24. Houghton, P. J., & Manby, J. (1985). Medicinal plants of the Mapuche. Journal of Ethnopharmacology, 13(1), 89-103.
25. Anesini, C., & Perez, C. (1993). Screening of plants used in Argentine folk medicine for antimicrobial activity. Journal of ethnopharmacology, 39(2), 119-128.
26. Gibaud, S., & Attivi, D. (2012, June 5). Microemulsions for oral administration and their therapeutic applications. Expert Opinion on Drug Delivery, 9(8), 937–951. https://doi.org/10.1517/17425247.2012.694865
27. Gull, A., Ahmed, S., Ahmad, F. J., Nagaich, U., & Chandra, A. (2020, August). Hydrogel thickened microemulsion; a local cargo for the co- delivery of cinnamaldehyde and berberine to treat acne vulgaris. Journal of Drug Delivery Science and Technology, 58, 101835. https://doi.org/10.1016/j.jddst.2020.101835
28. Elsheikh, M. A., Elnaggar, Y. S., Hamdy, D. A., & Abdallah, O. Y. (2018, January). Novel cremochylomicrons for improved oral bioavailability of the antineoplastic phytomedicine berberine chloride: Optimization and pharmacokinetics. International Journal of Pharmaceutics, 535(1–2), 316–324. https://doi.org/10.1016/j.ijpharm.2017.11.023
29. CN104825389A - Berberine hydrochloride self-microemulsion preparation having good oral bioavailability and preparation method thereof - Google Patents. (2015, April 10). CN104825389A - Berberine Hydrochloride Self-microemulsion Preparation Having Good Oral Bioavailability and Preparation Method Thereof - Google Patents. https://patents.google.com/patent/CN104825389A/en
30. Zhu, J. X., Tang, D., Feng, L., Zheng, Z. G., Wang, R. S., Wu, A. G., Duan, T. T., He, B., & Zhu, Q. (2012, May 8). Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride. Drug Development and Industrial Pharmacy, 39(3), 499–506. https://doi.org/10.3109/03639045.2012.683875
31. Gui, Sh & Wu, L & Peng, D.Y. & Liu, Q.Y. & Yin, B.P. & Shen, J.. (2008). Preparation and evaluation of a microemulsion for oral delivery of berberine. Die Pharmazie. 63. 516-9. 10.1691/ph.2008.8018.
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Dec 07, 2022
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Priyanka Singh Rajora, & Dr.Jitendra Singh Rajawat. (2022). ADVANCEMENTS IN BERBERINE-LOADED MICROEMULSION FOR ORAL DELIVERY: A COMPREHENSIVE REVIEW. Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 4229-4238. https://doi.org/10.53555/qbc4dy58
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Author Biographies
Priyanka Singh Rajora
Research Scholar, Bhupal nobles' University
Dr.Jitendra Singh Rajawat
Associate professor, Bhupal nobles' University
How to Cite
Priyanka Singh Rajora, & Dr.Jitendra Singh Rajawat. (2022). ADVANCEMENTS IN BERBERINE-LOADED MICROEMULSION FOR ORAL DELIVERY: A COMPREHENSIVE REVIEW. Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 4229-4238. https://doi.org/10.53555/qbc4dy58