ASSESSING LIPID PROFILES AND LIVER FUNCTION IN ALCOHOLIC AND NON-ALCOHOLIC FATTY LIVER DISEASE: A COMPARATIVE PERSPECTIVE
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Keywords
Alcoholic fatty liver disease, non-alcoholic fatty liver disease, lipid profile
Abstract
Background: The aim of the present study was to compare the lipid profile and liver function tests in individuals diagnosed with alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD).
Methods: This was a cross-sectional study conducted on 50 AFLD and 50 NAFLD patients. We measured lipid parameters and liver function tests using standard methods on Biosystem BA-400 chemistry analyzer. In addition, we have also calculated De Ritis ratio in both AFLD and NAFLD patients.
Results: Patients with AFLD showed significantly higher levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C) compared to those with NAFLD. In contrast, HDL-C levels were notably lower in AFLD patients than in those with NAFLD. Additionally, AFLD patients had elevated serum levels of aspartate aminotransferase (AST), total bilirubin, and the AST/ALT ratio compared to individuals with NAFLD.
Conclusion: Atherogenic dyslipidemia and elevated AST and AST/ALT (De Ritis) ratio were more prominent in AFLD patients than in NAFLD, suggesting the De Ritis ratio as a potential marker to differentiate between the two conditions.
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Rahul Dubey
Department of Biochemistry, Shyam Shah Medical College, Rewa
Keshav Singh
Department of Medicine, Shyam Shah Medical College, Rewa
Kapila Gaikwad
Department of Biochemistry, Shyam Shah Medical College, Rewa
Ravindra Saxena
Department of Biochemistry, Shyam Shah Medical College, Rewa
Yar Mohammed Ansari
Department of Biochemistry Shyam Shah Medical College, Rewa
Vedika Rathore
Department of Biochemistry, Shyam Shah Medical College, Rewa