ANTIDEPRESSANT ACTIVITY OF LAGENARIA SICERARIA L. SEEDS USING FORCED SWIM AND TAIL SUSPENSION TESTS
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Keywords
Lagenaria siceraria, anti-depressant, tail suspension, and forced swim test
Abstract
Traditionally Lagenaria siceraria was used for the treatment of various ailments both in males and females and evidences a great therapy for cures pain, ulcers, and fever, and it is used for pectoral cough, asthma, and other bronchial disorders. This study is planned to estimate the antidepressant action of ethanol extract of Lagenaria siceraria seeds at doses of 100 and 500 mg/kg by using two models i.e., a tail suspension test and a forced swim test. Significant antidepressant results were noted as compared to the control. The study results indicate that plant extracts are effective as antidepressants.
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ishrat younus
Faculty of Pharmacy, Hamdard University, Karachi, Pakistan
Faiza Anjum
Faculty of Pharmacy, Hamdard University, Karachi, Pakistan
Rafia Sadaf
Jinnah College of Pharmacy, Sohail University, Karachi, Pakistan
Nimra Mujeeb
Faculty of Pharmacy, Hamdard University, Karachi, Pakistan
Noor ul Ain
Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan
Talha bin Fayyaz
Faculty of Pharmacy, Ziauddin University, Karachi, Pakistan
Zubia Begum
Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan
Marium Mumtaz
Faculty of Pharmacy, Hamdard University, Karachi, Pakistan