CAUSES OF ADULT BRONCHIECTASIS IN NON CYSTIC FIBROSIS IN PATIENTS PRESENTING IN A TERTIARY CARE HOSPITAL OF KPK
Main Article Content
Keywords
Bronchiectasis, COPD, Non-cystic fibrosis, Pakistan, Tuberculosis, HRCT, Prospective Cohort.
Abstract
Background: Non-cystic fibrosis bronchiectasis remains a significant public health concern, particularly in low and middle-income countries like Pakistan, where limited research has been conducted on its causes. The disease is characterized by chronic airway inflammation and recurrent infections, leading to a spectrum of clinical presentations and necessitating comprehensive etiological investigation.
Objective: To identify the predominant causes of non-cystic fibrosis bronchiectasis among adults in a tertiary care hospital in Khyber Pakhtunkhwa (KPK), Pakistan.
Methods: This prospective observational cohort study included 120 patients diagnosed with non-cystic fibrosis bronchiectasis based on clinical presentation and HRCT findings. Participants aged 20-80 years who provided written informed consent were included. The study excluded patients with ILD, traction bronchiectasis, cystic fibrosis, and those with a history of childhood onset bronchiectasis. Data were collected via structured questionnaires and analyzed using descriptive and inferential statistics.
Results: The study revealed that infectious causes were the most prevalent, with tuberculosis (TB) accounting for 55% (n=66) of the cases, followed by pneumonia at 10% (n=12). COPD was identified in 15% (n=18) of the patients, ABPA in 7% (n=8), idiopathic causes in 8% (n=10), non-tuberculous mycobacteria (NTB) in 3% (n=4), and Kartagener syndrome in 2% (n=2). The mean age of participants was 51.99 years (SD=15.74), with a predominance of males (65%, n=78).
Conclusion: The study highlights post-TB bronchiectasis as the leading cause of non-cystic fibrosis bronchiectasis in the adult population of KPK, underscoring the need for targeted interventions focusing on TB management and prevention.
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Dr Gullali
Postgraduate Trainee Medicine, CMH, Peshawar - Pakistan
Dr Maryam Hussain
MBBS, FCPS Medicine, FCPS Pulmonology, Assistant Professor, Classified Medical Specialist & Pulmonologist, CMH, Peshawar - Pakistan
Dr Wahaj Ul Hassan
MBBS, FCPS Medicine, FCPS Neurology, Classified Medical Specialist & Neurologist, CMH, Peshawar - Pakistan
Dr Hafsa Waqar
Postgraduate Trainee Medicine, CMH, Peshawar - Pakistan
Dr Saliha Wazir
Postgraduate Trainee Medicine, CMH, Peshawar - Pakistan
Dr Mehroon Razzaq
Postgraduate Trainee Medicine, CMH, Peshawar - Pakistan