THYROID PROFILE IN HYPOTHYROID PREGNANT WOMEN: A PROSPECTIVE CASE CONTROL STUDY
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Keywords
Hypothyroidism, Pregnancy, Thyroid profile, non-pregnant women
Abstract
Background: Thyroid dysfunction is the second most common endocrinological disorder seen during pregnancy. The main cause of hypothyroidism is a thyroid abnormality majorly with iodine deficiency. Thyroid hormones play a crucial role in the placental development. So, this study to assess thyroid levels in pregnant women who are hypothyroid.
Methods: The study included 70 hypothyroid pregnant and 70 non-pregnant women, with institutional ethical committee approval and informed written consent obtained. The student t test was used to compare thyroid hormones. Thyroid profile was done by fully auto COBAS 6000 system analyzer. all women with TSH level>2.5 mIU/l, considered to be hypothyroid
Results: A total of 140 women. Group 1 included all women with TSH levels greater than 2.5 mIU/l, who were considered hypothyroid (n=70); Group 2 included women with euthyroid status and TSH levels ranging from 0.1 to 2.5 mIU/l (n=70). Table 1 showed maternal characteristics. Graph-1 displayed the mean thyroid profile values, which included TSH, T3, and T4 levels.
Conclusion: The study's findings are useful for detecting thyroid dysfunction early in pregnancy and avoiding adverse maternal and fetal outcomes.
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Priti Yadav
Assistant Professor, Department of Biochemistry, GS Medical College & Hospital, Pilkhuwa, Hapur, Uttar Pradesh, India
Jigar Katwala
Associate Professor, Department of Pharmacology, Swaminarayan Institute of Medical Sciences and Research, Kalol, Gandhinagar, Gujarat, India
Keyur Madhu
Assistant Professor, Department of Biochemistry, GMERS Medical College, Rajpipla, Gujarat, India
Smita Rani Pradhan
Assistant Professor, Department of Physiology, Raipur Institute of Medical Sciences, Raipur, Chhattisgarh, India