ENHANCING ORAL HYPOGLYCEMIC THERAPY: DEVELOPMENT AND EVALUATION OF GLIPIZIDE FLOATING DRUG DELIVERY SYSTEM FOR PROLONGED DRUG RELEASE
Main Article Content
Keywords
Glipizide, gastroretentive, floating drug delivery, sustained release, hypoglycemia
Abstract
Objectives: This study aimed to develop and evaluate a floating drug delivery system for an oral hypoglycemic agent, Glipizide.
Methods: Floating tablets of Glipizide were formulated using HPMC K4M, sodium alginate, and xanthan gum as polymers. Both pre-compression and post-compression evaluations were conducted according to pharmacopoeia standards. The tablets were prepared via direct compression method. Dissolution tests were performed using a USP dissolution testing apparatus II.
Results: FTIR analysis confirmed the compatibility of Glipizide with the selected polymers, indicating no interactions. Release data were analyzed using various models to determine release kinetics and mechanisms, revealing a non-Fickian diffusion mechanism. Increasing polymer concentrations significantly extended the floating lag time.
Interpretation and Conclusion: Dissolution studies indicated that the formulation containing sodium alginate provided superior sustained release. The release kinetics of all formulations adhered to a non-Fickian mechanism. The developed floating tablets of Glipizide demonstrated potential for prolonged drug release up to 12 hours, enhancing bioavailability and patient compliance.
References
2. Ramesh B, Rongala ASN, Madhusudan RY, Kishan V. Development and evaluation of gastroretentive norfloxacin floating tablets. Acta Pharm 2009 April 22(59):211–221.
3. Mahesh C, Paras J, Sachin C, Rajesh S, Pradeep V. Development of sustained release gastroretentive drug delivery system for ofloxacin: In vitro and in vivo evaluation. International Journal of Pharmaceutics 2005 (304)178–184.
4. Sangekar S, Vadino UTA, Chaudry I, Parr A, Beihn R, Digenis G. Evaluation of the effect of food and specific gravity of tablets on gastric retention time. International Journal of Pharmaceutics 1987 (35):187-191.
5. Ayhan S, Yalçın O, As¸kın I. Preparation and in vitro evaluation of sustained release tablet formulations of diclofenac sodium. IL Farmaco 2005 (60):171–177.
6. Streubel A, Siepmann J, Bodmeier R. Floating matrix tablets based on low density foam powder: effects of formulation and processing parameters on drug release. European Journal of Pharmaceutical Sciences 2003 (18):37–45.
7. Lachman N, Liberman HA, The theory and practice of industrial pharmacy. 3rd ed Varghese Publishing House, Mumbai, 1987 p 66-88.
8. Parmar PD, Pande S, Shah SH, Sonara N, Patel GH. Floating drug delivery system: A novel approach to prolong gastric retention. World J Pharmacy Pharm Sci. 2014 Feb 25;3(4):418-44.
9. Patel N, Nagesh C, Chandrashekhar S, Jinal P, Devdatt J. Floating drug delivery system: an innovative acceptable approach in gastro retentive drug delivery. Asian Journal of Pharmaceutical Research. 2012;2(1):7-18.
10. Sathish D, Himabindu S, Shravan Kumar Y, Madhusudan Rao Y. Floating drug delivery systems for prolonging gastric residence time: a review. Current drug delivery. 2011 Sep 1;8(5):494-510.
11. Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. Journal of Controlled release. 2000 Feb 3;63(3):235-59.
12. Patel A, Ray S, Thakur RA. Invitro evaluation and optimization of controlled release floating drug delivery system of metformin hydrochloride.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
M. Priyanka
Department of Pharmaceutics, Safa College of Pharmacy, Kurnool
MISBA
Assistant Professor, Safa College of Pharmacy, Kurnool
K. Lakshmikanth
Research scholar Department of Pharmaceutics, Safa College of Pharmacy, Kurnool
Shaik Neha Samreen
Research scholar Department of Pharmaceutics, Safa College of Pharmacy, Kurnool
MD Iftekhar Ahmed khan
Associate Professor, Department of Pharmaceutics, Safa College of Pharmacy, Kurnool
B Sandhya Rani
Assistant Professor, Safa College of Pharmacy, Kurnool
Dr. Md Sultan Ali Basha
Professor and Principal, Safa College of Pharmacy, Kurnool