TO EVALUATE THE CLINICAL EFFICACY OF WHOLE BRAIN RADIOTHERAPY CONCOMITANT WITH TEMOZOLAMIDE IN BRAIN METASTASES

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Dr Imran Farooq
Dr Aakif Ullah Khan
Dr Abbas Ilyas
Dr Sami Ullah
Dr Noor Ul Ain
Dr Asad Zamir
Dr Zainab Jan
Dr Naheed Akhtar
Dr Sana Ullah

Keywords

Temozolomide, Whole brain radiotherapy, Brain metastases.

Abstract

Objectives: 



  • To assess the Improvement in Signs and symptoms.

  • To assess 90 days progression free survival

  • To assess the Radiological response at day 30 and 90 with MRI brain.


Materials and Methods:  In this Randomized control trial, total of 4o patients were enrolled.


The enrolled patients were divided into two groups. Group A patients were treated with WBRT alone while Group B patients were treated with WBRT and TMZ. The radiologic response at Day 30 and the 90-day progression-free survival of the BM served as the main efficacy indicators.


Results: In our 40 patient study, 20 patients underwent RT alone and 20 received WBRT and


TMZ. No statistically significant differences were found between the both groups. In 30 days response 2 (10.0%) patients shows complete response and 6 (30%) shows partial response in each group. 8 (40.0%) patients shows stable disease condition in group A while 9 (45.0%) patients shows progressive disease condition in group B patients. At 90 days, the radiologic response was assessed and it was noted that there was no statistically significant difference between the groups. Conclusion: Concurrent treatment of RT and TMZ was well tolerated and improved BM's 90day progression-free survival rate considerably. These findings indicate that TMZ might enhance local BM management, but caution should be exercised.

Abstract 43 | PDF Downloads 26

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