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Jannat Gull Khan
Muhammad Imran Hussain
Gullnoor Khan
Sobia Ikram Sheikh
Tasbiha Irfan
Shiza Maryem
Hina Mushtaq
Eman Shakeel
Komal Rahid
Huba Khalid


Bone resorption, Bone Mineral Density, Folic acid, Potassium, Postmenopausal Osteoporosis


Osteoporosis is a disorder in which bones become brittle and risk of fractures increases and is also becoming common day by day. In US, almost 10 million women and men are affected by this disease. Previously, among all nutrients most of the attention was given to calcium and vitamin D for treating bone disorders but now latest studies suggest that other nutrients such as Folic acid, vitamin B12 and Potassium are also beneficial for bones in addition to vitamin D and calcium. The objective of this study was to evaluate the collective role of Folic acid and Potassium supplementation against loss of Bone Mineral Density in Postmenopausal Osteoporotic women. This study was conducted on postmenopausal osteoporotic women of age 35 to 55 years at Jinnah Hospital, Lahore. The duration of this study was 3 months and study design was Randomized Control trial. The sample size 60 was divided in to two groups. Pre and post testing was done. Group A was control group which did not receive any supplementation while group B was intervention group and received folic acid and potassium supplementation. Results showed positive outcomes and concluded that both folic acid and potassium supplementation have significant effect (p<0.05) as they both increase bone anabolism, lower bone resorption, decrease bone stress and fatigue, while value for BMD remained same.

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1. Akkawi, I., & Zmerly, H. (2018). Osteoporosis: Current concepts. Joints, 6(2), 122.
2. Drake, M. T., Clarke, B. L., & Lewiecki, E. M. (2015). The pathophysiology and treatment of osteoporosis. Clinical Therapeutics, 37(8), 1837–1850.
3. Eastell, R., O’Neill, T. W., Hofbauer, L. C., Langdahl, B., Reid, I. R., Gold, D. T., & Cummings, S. R. (2016). Postmenopausal osteoporosis. Nature Reviews Disease Primers, 2(1), 1–16.
4. Gregory, N. S., Kumar, R., Stein, E. M., Alexander, E., Christos, P., Bockman, R. S., & Rodman, J. S. (2015). Potassium citrate decreases bone resorption in postmenopausal women with osteopenia: A randomized, double-blind clinical trial. Endocrine Practice, 21(12), 1380–1386.
5. Hussain, M. I., Ahmed, W., Nasir, M., Mushtaq, M. H., Sheikh, A. A., Shaheen, A. Y., & Mahmood, A. (2019). Immune boosting role of vitamin E against pulmonary tuberculosis. Pakistan Journal of Pharmaceutical Sciences, 32. No 1 (Page 269- 276)
6. Hussain, M. I., Ahmed, W., Nasir, M., Mushtaq, M. H., Sheikh, A. A., Shaheen, A. Y., Ali, S., & Iqbal, S. (2019). Immune modulatory and anti-oxidative effect of selenium against pulmonary tuberculosis. Pakistan Journal of Pharmaceutical Sciences, 32. No 2 (Page 779-784)
7. Kong, S. H., Kim, J. H., Hong, A. R., Lee, J. H., Kim, S. W., & Shin, C. S. (2017). Dietary potassium intake is beneficial to bone health in a low calcium intake population: The Korean National Health and Nutrition Examination Survey (KNHANES) (2008–2011). Osteoporosis International, 28(5), 1577–1585.
8. Ratajczak, A. E., Rychter, A. M., Zawada, A., Dobrowolska, A., & Krela-Kaźmierczak, I. (2020). Nutrients in the prevention of osteoporosis in patients with inflammatory bowel diseases. Nutrients, 12(6), 1702.
9. Rondanelli, M., Tartara, A., Fossari, F., Vecchio, V., Faliva, M. A., Naso, M., Perna, S., Nichetti, M., & Peroni, G. (2022). Adequate intake and supplementation of B vitamins, in particular folic acid, can play a protective role in bone health. Current Aging Science, 15(2), 110–120.
10. Sahni, S., Mangano, K. M., McLean, R. R., Hannan, M. T., & Kiel, D. P. (2015). Dietary Approaches for Bone Health: Lessons from the Framingham Osteoporosis Study. Current Osteoporosis Reports, 13(4), 245–255.
11. Salari, P., Abdollahi, M., Heshmat, R., Meybodi, H. A., & Razi, F. (2014). Effect of folic acid on bone metabolism: A randomized double blind clinical trial in postmenopausal osteoporotic women. DARU Journal of Pharmaceutical Sciences, 22(1), 62.
12. The National Osteoporosis Guideline Group (NOGG), Compston, J., Cooper, A., Cooper, C., Gittoes, N., Gregson, C., Harvey, N., Hope, S., Kanis, J. A., McCloskey, E. V., Poole, K. E. S., Reid, D. M., Selby, P., Thompson, F., Thurston, A., & Vine, N. (2017). UK clinical guideline for the prevention and treatment of osteoporosis. Archives of Osteoporosis, 12(1), 43.
13. Tu, K. N., Lie, J. D., Wan, C. K. V., Cameron, M., Austel, A. G., Nguyen, J. K., Van, K., & Hyun, D. (2018). Osteoporosis: A review of treatment options. Pharmacy and Therapeutics, 43(2), 92.
14. Vijayakumar, A., Kim, E., Kim, H., Choi, Y. J., Huh, K. B., & Chang, N. (2017). Effects of folic acid supplementation on serum homocysteine levels, lipid profiles, and vascular parameters in post-menopausal Korean women with type 2 diabetes mellitus. Nutrition Research and Practice, 11(4), 327–333.

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