COMPARISON OF PLATELET-RICH PLASMA DRESSING VERSUS PLACENTAL EXTRACT GEL DRESSING IN THE MANAGEMENT OF DIABETIC FOOT ULCER AND ITS OUTCOME

Main Article Content

Indrajit Ananda Kannan
Shanthi Ponnandai Swaminathan
Vikas Kawarat
Rajeshwari Mani
Arul Kumar Chinnappan

Keywords

diabetic foot ulcers,, DFUs, platelet-rich plasma, PRP dressing, placental extract gel dressing, Bates-Jensen Wound Assessment Scale, wound healing

Abstract

Introduction: This study addresses the growing healthcare challenge of diabetic foot ulcers (DFUs), a severe complication of diabetes mellitus, by comparing the effectiveness of platelet-rich plasma (PRP) dressing versus placental extract gel dressing. These ulcers can lead to significant morbidity, including amputations, thereby affecting patients' quality of life.


Objective: To compare the efficacy of PRP dressing versus placental extract gel dressing in the management of DFUs, using the Bates-Jensen Wound Assessment Scale for outcome measurement.


Methodology: A randomized control trial was conducted at the Institute of General Surgery, Madras Medical College, and Rajiv Gandhi Government General Hospital, Chennai, involving 84 patients with diabetic foot ulcers. Patients were randomly assigned to two groups: Group A received placental extract gel dressing, and Group B received PRP dressing. The study followed strict inclusion and exclusion criteria, with a comprehensive analysis plan using IBM SPSS Statistics software for data analysis.


Results: The study found significant differences in wound healing rates between the two groups. All patients in the PRP dressing group (Group B) achieved complete wound closure, while none in the placental extract gel dressing group (Group A) did. Furthermore, the reduction in the Bates-Jensen Wound Assessment Scale score was greater and faster in the PRP dressing group, indicating a more efficient healing process.


Conclusion: PRP dressing demonstrates a significant advantage over placental extract gel dressing in promoting the healing of diabetic foot ulcers, as evidenced by higher wound closure rates and improved Bates-Jensen Wound Assessment Scale scores. This therapeutic approach shows promise in the management of DFUs, contributing to better patient outcomes and reduced complications.

Abstract 38 | pdf Downloads 14

References

1. Hirase T, Ruff E, Surani S, Ratnani I. Topical application of platelet-rich plasma for diabetic foot ulcers: A systematic review. World Journal of Diabetes. 2018;9(10):172-179.
2. Babaei V, Afradi H, Gohardani H, Nasseri F, Azarafza M, Teimourian S. Management of chronic diabetic foot ulcers using platelet-rich plasma. Journal of Wound Care. 2017;26(12):784-787.
3. Tsachiridi M, Galyfos G, Andreou A, Sianou A, Sigala F, Zografos G et al. Autologous Platelet-Rich Plasma for Nonhealing Ulcers: A Comparative Study. Vascular Specialist International. 2019;35(1):22-27.
4. Prakasam N, M.S. P, S. R, K. L, K. S. A clinical study of platelet rich plasma versus conventional dressing in management of diabetic foot ulcers. International Surgery Journal. 2018;5(10):3210.
5. Rai R, Somani A. Comparison of efficacy of autologous platelet-rich fibrin versus saline dressing in chronic venous leg ulcers: A randomised controlled trial. Journal of Cutaneous and Aesthetic Surgery. 2017;10(1):8.
6. A Randomized Trial on Platelet Rich Plasma Versus Saline Dressing of Diabetic Foot Ulcers. Case Medical Research. 2019;.
7. Abd El-Mabood E, Ali H. Platelet-rich plasma versus conventional dressing: does this really affect diabetic foot wound-healing outcomes?. The Egyptian Journal of Surgery. 2018;37(1):16.
8. Conde-Montero E, de la Cueva Dobao P, Martínez González J. Platelet-rich plasma for the treatment of chronic wounds: evidence to date. Chronic Wound Care Management and Research. 2017; Volume 4:107-120.