THE METABOLISM OF BERBERINE AND ITS CONTRIBUTION TO THE PHARMACOLOGICAL EFFECTS

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Abdullah Ahmad Adawi
Abed Abdullah Qashqari
Shoug Odah Alhamdi
Basmah Hussain Ageeli
Ibtisam Hussain Alharbi
Najwan Fahad Abuzinadah
Haneen Ahmad Abduljabbar Aljubailan

Keywords

berberine, metabolism, pharmacological effects, bioavailability, enzymes

Abstract

Berberine is a natural compound found in various medicinal plants, such as Berberis vulgaris and Hydrastis Canadensis. It has been used in traditional medicine for centuries and has gained popularity in recent years due to its various pharmacological effects, including anti-inflammatory, antimicrobial, and antidiabetic properties. The metabolism of berberine plays a crucial role in its pharmacological effects, as it affects the bioavailability and distribution of the compound in the body. In this essay, we will explore the metabolism of berberine and its contribution to its pharmacological effects, discussing the key enzymes involved in berberine metabolism, as well as the factors that influence its metabolism and bioavailability.

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