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Moeez Saqib
Mbony Joshua Cho
Dr. Nishat waqas
Amgad Samir Abdelmageed Mohamed Elfeki
FNU Vishal
Aarti Kumari
Muodiaju Chiazor Joan
Ahmed Samir Abdelmageed Mohamed Elfiki


glucose, sodium, cotransporter, diabetes, cardioprotection, cost-effectiveness


Introduction: Type 2 diabetes mellitus (T2DM) poses a significant economic burden due to its association with cardiovascular complications, making it a leading cause of premature mortality and straining healthcare systems.

Methods: A systematic electronic search was conducted for clinical trials published between January 2015 and January 2023 in PubMed, Scopus, Web of Science, and ScieLO databases. These trials evaluated the safety and efficacy of sodium-glucose cotransporter inhibitors (SGLT2i) in patients with T2DM and established cardiovascular disease, focusing on standard treatment and cost-effectiveness analysis.

Results: The addition of SGLT2i to standard therapy led to notable reductions in rates of acute myocardial infarction, stroke, cardiovascular death, and hospitalization for heart failure. The observed decrease in cardiovascular events offset the costs associated with SGLT2i therapy, demonstrating a favorable utilization of healthcare resources.

Conclusions: Given that cardiovascular events are the primary cause of mortality in patients with T2DM and cardiovascular disease, there is a pressing need for the development of therapies that not only improve glycemic control but also mitigate cardiovascular risks. These findings underscore the emergence of an evidence-based approach to managing such patients, heralding a new era in clinical practice.

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