DECIPHERING THE HUMAN MICROBIOME: USING NEXT-GENERATION SEQUENCING DATA AND BIOINFORMATICS APPROACHES

Abstract

The human microbiome, comprising trillions of microbial cells residing within and on our bodies, plays a fundamental role in maintaining health and contributing to the pathogenesis of various diseases. This paper synthesizes findings from recent studies to elucidate the complex interactions between the microbiome, host genetics, diet, and immune function. By examining the role of the microbiome in health states ranging from metabolic disorders to neurodegenerative diseases, we highlight the potential for microbiome-based interventions in personalized medicine approaches. However, we also acknowledge the challenges and limitations associated with translating microbiome research into clinical practice.