PHARMACOKINETIC CONSIDERATIONS IN SPECIAL PATIENT POPULATIONS: PEDIATRICS, PREGNANCY, AND THE ELDERLY
Main Article Content
Keywords
Pharmacokinetics, pediatrics, pregnancy, elderly, drug therapy, special populations
Abstract
Pharmacokinetics, the study of how drugs are absorbed, distributed, metabolized, and excreted by the, plays a crucial role in determining the efficacy and safety of medications in patients. Special patient populations, such as pediatrics, pregnancy, and the elderly, present unique challenges in the pharmacokinetic considerations of drug therapy. This essay explores the specific pharmacokinetic considerations in these populations and discusses the implications for clinical practice.
References
1. Anderson BJ, Holford NH. Mechanism-based concepts of size and maturity in pharmacokinetics. Annu Rev Pharmacol Toxicol. 2008;48:303-32.
2. Johnson TN, Rostami-Hodjegan A, Goddard JM, Tanner MS. The influence of maturation on drug clearance from the neonate to adult. Br J Clin Pharmacol. 2005;59(2):121-30.
3. Hebert MF. Pharmacokinetics: Pediatric clinical pharmacology. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2001.
4. Greenhill LL, Ross R, Friedman E, eds. Drug therapy for the elderly. New York: Springer; 2007.
5. Langer O, Thummel KE, et al. Motherisk update. Pharmacol Rev. 1997;49(3):301-6.
6. Kennedy D, Clarke T. Pharmacokinetics in pregnancy and lactation. Clin Pharmacokinet. 2006;45(10):1201-12.
7. Abou-Auda HS. Pharmacokinetics and drug metabolism in the elderly. Drug Metab Rev. 2004;36(3-4):309-23.
8. Hoggart C. Population and reproductive health: an introduction for health and social workers. London: Routledge;2016.
9. Palleria C, Di Paolo A, Giofrè C, et al. Pharmacokinetic drug-drug interaction and their implication in clinical management. J Res Med Sci. 2013;18(7):601-10.
10. Benet LZ, Gallo JM. Pharmacokinetics: The dynamics of drug absorption, distribution, metabolism, and elimination. In: Fitzpatrick RW, ed. Basic and Clinical Pharmacology. New York: McGraw-Hill; 2012.
2. Johnson TN, Rostami-Hodjegan A, Goddard JM, Tanner MS. The influence of maturation on drug clearance from the neonate to adult. Br J Clin Pharmacol. 2005;59(2):121-30.
3. Hebert MF. Pharmacokinetics: Pediatric clinical pharmacology. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2001.
4. Greenhill LL, Ross R, Friedman E, eds. Drug therapy for the elderly. New York: Springer; 2007.
5. Langer O, Thummel KE, et al. Motherisk update. Pharmacol Rev. 1997;49(3):301-6.
6. Kennedy D, Clarke T. Pharmacokinetics in pregnancy and lactation. Clin Pharmacokinet. 2006;45(10):1201-12.
7. Abou-Auda HS. Pharmacokinetics and drug metabolism in the elderly. Drug Metab Rev. 2004;36(3-4):309-23.
8. Hoggart C. Population and reproductive health: an introduction for health and social workers. London: Routledge;2016.
9. Palleria C, Di Paolo A, Giofrè C, et al. Pharmacokinetic drug-drug interaction and their implication in clinical management. J Res Med Sci. 2013;18(7):601-10.
10. Benet LZ, Gallo JM. Pharmacokinetics: The dynamics of drug absorption, distribution, metabolism, and elimination. In: Fitzpatrick RW, ed. Basic and Clinical Pharmacology. New York: McGraw-Hill; 2012.