Reducing Adverse Reactions to Contrast Agents: A Multidisciplinary Approach Integrating Health Administration, Radiology, Nursing, Pharmacy, and Allergy Specialists
Main Article Content
Keywords
Contrast agents, adverse reactions, multidisciplinary approach, health administration, radiology, nursing, pharmacy, allergy
Abstract
Contrast-enhanced imaging procedures are widely used for diagnostic purposes, but adverse reactions to contrast agents remain a significant concern. This article explores a multidisciplinary approach to reducing adverse reactions, integrating perspectives from health administration, radiology, nursing, pharmacy, and allergy specialists. We discuss the types and incidence of adverse reactions, risk factors, and strategies for prevention and management. Key interventions include appropriate patient screening and preparation, proper contrast administration techniques, monitoring and emergency response protocols, and interprofessional collaboration. By implementing a coordinated, multidisciplinary approach, healthcare institutions can enhance patient safety and quality of care in contrast-enhanced imaging procedures.
References
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Brockow, K., Romano, A., Blanca, M, et al. (2002). General considerations for skin test procedures in the diagnosis of drug hypersensitivity. Allergy, 57(1), 45–51.
Brockow, K., Sánchez-Borges, M. (2014). Hypersensitivity to contrast media and dyes. Immunol Allergy Clin North Am, 34(3), 547-64.
Caimmi, S., Benyahia, B., Suau, D., et al. (2010). Clinical value of negative skin tests to iodinated contrast media. Clin Exp Allergy, 40(5), 805–10.
Christiansen, C. (2005). X-ray contrast media--an overview. Toxicology, 209(2), 185–7.
Clement, O., Dewachter, P., Mouton-Faivre, C., et al. (2018). Immediate Hypersensitivity to Contrast Agents: The French 5-year CIRTACI Study. EClinicalMedicine, 1, 51–61.
Corbaux, C., Seneschal, J., Taïeb, A., et al. (2017). Delayed cutaneous hypersensitivity reactions to iodinated contrast media. Eur J Dermatol, 27(2), 190–1.
Dillman, J. R., Ellis, J. H., Cohan, R. H., et al. (2007). Frequency and Severity of Acute Allergic-Like Reactions to Gadolinium-Containing IV Contrast Media in Children and Adults. American Journal of Roentgenology, 189(6), 1533–8.
Forbes-Amrhein, M. M., Dillman, J. R., Trout, A. T., et al. (2018). Frequency and Severity of Acute Allergic-Like Reactions to Intravenously Administered Gadolinium-Based Contrast Media in Children. Invest Radiol, 53(5), 313–8.
Fok, J. S., Smith, W. B. (2017). Hypersensitivity reactions to gadolinium-based contrast agents. Curr Opin Allergy Clin Immunol, 17(4), 241–6.
Greenberger, P. A., Patterson, R. (1991). The prevention of immediate generalized reactions to radiocontrast media in high-risk patients. Journal of Allergy and Clinical Immunology, 87(4), 867–72.
Katayama, H., Yamaguchi, K., Kozuka, T., et al. (1990). Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media. Radiology, 175(3), 621–8.
Kornblau, I. S., El-Annan, J. F. (2019). Adverse reactions to fluorescein angiography: A comprehensive review of the literature. Surv Ophthalmol, 64(5), 679–93.
Lee, T., Sanderson, D., Doyle, P. (2018). Anaphylactic Shock After Intravenous Fluorescein Administration for Intraoperative Cystoscopy. Obstet Gynecol, 131(4), 727–9.
Mayorga, C., Celik, G., Rouzaire, P., et al. (2016). In vitro tests for drug hypersensitivity reactions: an ENDA/EAACI Drug Allergy Interest Group position paper. Allergy, 71(8), 1103–34.
Muraro, A., Roberts, G., Worm, M., et al. (2014). Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology. Allergy, 69(8), 1026–45.
Rosado Ingelmo, A., Doña Diaz, I., Cabañas Moreno, R., et al. (2016). Clinical Practice Guidelines for Diagnosis and Management of Hypersensitivity Reactions to Contrast Media. J Investig Allergol Clin Immunol, 26(3), 144-55.
Sánchez-Borges, M., Aberer, W., Brockow, K., et al. (2019). Controversies in Drug Allergy: Radiographic Contrast Media. J Allergy Clin Immunol Pract, 7(1), 61–5.
Schrijvers, R., Breynaert, C., Ahmedali, Y., et al. (2018). Skin Testing for Suspected Iodinated Contrast Media Hypersensitivity. J Allergy Clin Immunol Pract, 6(4), 1246–54.
Sutton, A. G., Finn, P., Grech, E. D., Hall, J. A., Stewart, M. J., Davies, A., & De Belder, M. A. (2001). Early and late reactions after the use of iopamidol 340, ioxaglate 320, and iodixanol 320 in cardiac catheterization. American heart journal, 141(4), 677-683.
Tasker, F., Fleming, H., McNeill, G., et al. (2019). Contrast media and cutaneous reactions. Part 2: Delayed hypersensitivity reactions to iodinated contrast media. Clin Exp Dermatol. (Epub ahead of print)
Yoon, S. H., Lee, S.-Y., Kang, H.-R., et al. (2015). Skin tests in patients with hypersensitivity reaction to iodinated contrast media: a meta-analysis. Allergy, 70(6), 625–37.
Brockow, K., Christiansen, C., Kanny, G., et al. (2005). Management of hypersensitivity reactions to iodinated contrast media. Allergy, 60(2), 150–8.
Brockow, K., Romano, A., Blanca, M, et al. (2002). General considerations for skin test procedures in the diagnosis of drug hypersensitivity. Allergy, 57(1), 45–51.
Brockow, K., Sánchez-Borges, M. (2014). Hypersensitivity to contrast media and dyes. Immunol Allergy Clin North Am, 34(3), 547-64.
Caimmi, S., Benyahia, B., Suau, D., et al. (2010). Clinical value of negative skin tests to iodinated contrast media. Clin Exp Allergy, 40(5), 805–10.
Christiansen, C. (2005). X-ray contrast media--an overview. Toxicology, 209(2), 185–7.
Clement, O., Dewachter, P., Mouton-Faivre, C., et al. (2018). Immediate Hypersensitivity to Contrast Agents: The French 5-year CIRTACI Study. EClinicalMedicine, 1, 51–61.
Corbaux, C., Seneschal, J., Taïeb, A., et al. (2017). Delayed cutaneous hypersensitivity reactions to iodinated contrast media. Eur J Dermatol, 27(2), 190–1.
Dillman, J. R., Ellis, J. H., Cohan, R. H., et al. (2007). Frequency and Severity of Acute Allergic-Like Reactions to Gadolinium-Containing IV Contrast Media in Children and Adults. American Journal of Roentgenology, 189(6), 1533–8.
Forbes-Amrhein, M. M., Dillman, J. R., Trout, A. T., et al. (2018). Frequency and Severity of Acute Allergic-Like Reactions to Intravenously Administered Gadolinium-Based Contrast Media in Children. Invest Radiol, 53(5), 313–8.
Fok, J. S., Smith, W. B. (2017). Hypersensitivity reactions to gadolinium-based contrast agents. Curr Opin Allergy Clin Immunol, 17(4), 241–6.
Greenberger, P. A., Patterson, R. (1991). The prevention of immediate generalized reactions to radiocontrast media in high-risk patients. Journal of Allergy and Clinical Immunology, 87(4), 867–72.
Katayama, H., Yamaguchi, K., Kozuka, T., et al. (1990). Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media. Radiology, 175(3), 621–8.
Kornblau, I. S., El-Annan, J. F. (2019). Adverse reactions to fluorescein angiography: A comprehensive review of the literature. Surv Ophthalmol, 64(5), 679–93.
Lee, T., Sanderson, D., Doyle, P. (2018). Anaphylactic Shock After Intravenous Fluorescein Administration for Intraoperative Cystoscopy. Obstet Gynecol, 131(4), 727–9.
Mayorga, C., Celik, G., Rouzaire, P., et al. (2016). In vitro tests for drug hypersensitivity reactions: an ENDA/EAACI Drug Allergy Interest Group position paper. Allergy, 71(8), 1103–34.
Muraro, A., Roberts, G., Worm, M., et al. (2014). Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology. Allergy, 69(8), 1026–45.
Rosado Ingelmo, A., Doña Diaz, I., Cabañas Moreno, R., et al. (2016). Clinical Practice Guidelines for Diagnosis and Management of Hypersensitivity Reactions to Contrast Media. J Investig Allergol Clin Immunol, 26(3), 144-55.
Sánchez-Borges, M., Aberer, W., Brockow, K., et al. (2019). Controversies in Drug Allergy: Radiographic Contrast Media. J Allergy Clin Immunol Pract, 7(1), 61–5.
Schrijvers, R., Breynaert, C., Ahmedali, Y., et al. (2018). Skin Testing for Suspected Iodinated Contrast Media Hypersensitivity. J Allergy Clin Immunol Pract, 6(4), 1246–54.
Sutton, A. G., Finn, P., Grech, E. D., Hall, J. A., Stewart, M. J., Davies, A., & De Belder, M. A. (2001). Early and late reactions after the use of iopamidol 340, ioxaglate 320, and iodixanol 320 in cardiac catheterization. American heart journal, 141(4), 677-683.
Tasker, F., Fleming, H., McNeill, G., et al. (2019). Contrast media and cutaneous reactions. Part 2: Delayed hypersensitivity reactions to iodinated contrast media. Clin Exp Dermatol. (Epub ahead of print)
Yoon, S. H., Lee, S.-Y., Kang, H.-R., et al. (2015). Skin tests in patients with hypersensitivity reaction to iodinated contrast media: a meta-analysis. Allergy, 70(6), 625–37.
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Published
Apr 13, 2022
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Abdullah Saad Mashi Alotaibi, Abdullah Bander Sayer Alotaibi, Fahad Othman Alsalloom, Arwa Ali Alahmadi, Zakaria Ibrahim Asir, Mohammed Abdulrahman Albahkali, W. M. H. J. W. A. O. H. H. H. H. S. H. M. A. A. K. M. N. A. M. M. A. A. (2022). Reducing Adverse Reactions to Contrast Agents: A Multidisciplinary Approach Integrating Health Administration, Radiology, Nursing, Pharmacy, and Allergy Specialists. Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 904-912. https://doi.org/10.53555/jptcp.v29i04.5588
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All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Abdullah Saad Mashi Alotaibi, Abdullah Bander Sayer Alotaibi, Fahad Othman Alsalloom, Arwa Ali Alahmadi, Zakaria Ibrahim Asir, Mohammed Abdulrahman Albahkali, W. M. H. J. W. A. O. H. H. H. H. S. H. M. A. A. K. M. N. A. M. M. A. A. (2022). Reducing Adverse Reactions to Contrast Agents: A Multidisciplinary Approach Integrating Health Administration, Radiology, Nursing, Pharmacy, and Allergy Specialists. Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 904-912. https://doi.org/10.53555/jptcp.v29i04.5588