ADVANCED LABORATORY TESTING METHODS IN GASTROENTEROLOGY NURSING FOR EARLY DETECTION OF DRUG-INDUCED LIVER INJURY
Main Article Content
Keywords
induced liver injury, Gastroenterology nursing, Advanced laboratory testing methods, Biomarker analysis, Genetic testing, Early detection
Abstract
Drug-induced liver injury is a significant concern in clinical practice, as it can lead to severe complications if not detected and managed promptly. Gastroenterology nurses play a crucial role in monitoring patients for signs of DILI and implementing appropriate interventions to prevent further liver damage. By utilizing advanced laboratory testing methods, such as biomarker analysis, genetic testing, and imaging techniques, nurses can enhance their ability to identify DILI at an early stage, allowing for timely intervention and improved patient outcomes. This review discusses the current landscape of laboratory testing methods in gastroenterology nursing, their applications in detecting DILI, and the challenges and opportunities associated with their implementation in clinical practice. Furthermore, it highlights the importance of ongoing education and training for nurses to stay abreast of the latest advancements in laboratory testing for DILI detection.
References
2. Björnsson ES. Drug-induced liver injury: an overview over the most critical compounds. Arch Toxicol. 2015;89(3):327-334.
3. Teschke R, Danan G. Diagnosis and management of drug-induced liver injury (DILI) in patients with pre-existing liver disease. Drug Saf. 2016;39(8):729-744.
4. Chalasani N, Fontana RJ, Bonkovsky HL, et al. Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology. 2008;135(6):1924-1934.
5. Sgro C, Clinard F, Ouazir K, et al. Incidence of drug-induced hepatic injuries: a French population-based study. Hepatology. 2002;36(2):451-455.
6. Andrade RJ, Robles M, Fernández-Castañer A, López-Ortega S, López-Vega MC, Lucena MI. Assessment of drug-induced hepatotoxicity in clinical practice: a challenge for gastroenterologists. World J Gastroenterol. 2007;13(3):329-340.
7. Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med. 2006;354(7):731-739.
8. Reuben A, Koch DG, Lee WM; Acute Liver Failure Study Group. Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. Hepatology. 2010;52(6):2065-2076.
9. Lee WM. Drug-induced hepatotoxicity. N Engl J Med. 2003;349(5):474-485.
10. Lewis JH. Drug-induced liver injury throughout the drug development life cycle: where we have been, where we are now, and where we are headed. Drug Saf. 2016;39(9):801-814.
11. Aithal GP, Watkins PB, Andrade RJ, et al. Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther. 2011;89(6):806-815.
12. Lucena MI, Andrade RJ, Kaplowitz N, et al. Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex. Hepatology. 2009;49(6):2001-2009.
13. Robles-Díaz M, Medina-Caliz I, Stephens C, et al. Drug-induced liver injury: a review. Int J Mol Sci. 2016;17(9):E141.
14. Danan G, Teschke R. RUCAM in drug and herb induced liver injury: the update. Int J Mol Sci. 2016;17(1):E14.
15. Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55(6):2005-2023.
16. Björnsson ES. Hepatotoxicity by drugs: the most common implicated agents. Int J Mol Sci. 2016;17(2):E224.
17. Teschke R, Schwarzenboeck A, Hennermann KH. Causality assessment in hepatotoxicity by drugs and dietary supplements. Br J Clin Pharmacol. 2008;66(4):503-515.
18. Andrade RJ, Lucena MI, Fernández MC, Pelaez G, Pachkoria K, Garcia-Ruiz E, et al. Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology. 2005;129(2):512-521.
19. Reuben A. Hy's law. Hepatology. 2004;39(2):574-578.
20. Teschke R, Eickhoff A, Schulze J. Drug induced liver injury: can biomarkers assist RUCAM in causality assessment? Int J Mol Sci. 2017;18(4):E803.
21. Andrade RJ, Aithal GP, Björnsson ES, et al. EASL Clinical Practice Guidelines: drug-induced liver injury. J Hepatol. 2019;70(6):1222-1261.
22. Kaplowitz N. Drug-induced liver injury. Clin Infect Dis. 2004;38(Suppl 2):S44-S48.
23. Björnsson ES, Hoofnagle JH. Categorization of drugs implicated in causing liver injury: critical assessment based on published case reports. Hepatology. 2016;63(2):590-603.
24. Teschke R, Wolff A, Frenzel C, Schulze J, Eickhoff A. Drug induced liver injury: accuracy of diagnosis in published reports. Ann Hepatol. 2014;13(2):248-255.
25. Chalasani N, Bonkovsky HL, Fontana R, et al. Features and outcomes of 899 patients with drug-induced liver injury: the DILIN prospective study. Gastroenterology. 2015;148(7):1340-1352.
26. Fontana RJ. Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives. Gastroenterology. 2014;146(4):914-928.
27. Andrade RJ, Robles M, Ulzurrun E, Lucena MI. Drug-induced liver injury: insights from genetic studies. Pharmacogenomics. 2009;10(9):1467-1487.
28. Teschke R, Danan G. Drug induced liver injury with analysis of alternative causes as confounding variables. Br J Clin Pharmacol. 2018;84(7):1467-1477.
29. Aithal GP. Hepatotoxicity related to antirheumatic drugs. Nat Rev Rheumatol. 2011;7(3):139-150.
30. Björnsson ES, Bergmann OM, Björnsson HK, Kvaran RB, Olafsson S. Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology. 2013;144(7):1419-1425.
31. Andrade RJ, Lucena MI, Kaplowitz N, et al. Outcome of acute idiosyncratic drug-induced liver injury: long-term follow-up in a hepatotoxicity registry. Hepatology. 2006;44(6):1581-1588.
32. Reuben A, Koch DG, Lee WM; Acute Liver Failure Study Group. Acute liver failure study group. Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. Hepatology. 2010;52(6):2065-2076.
33. Lee WM. Acute liver failure. Semin Respir Crit Care Med. 2012;33(1):36-45.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Zainab abdullah alhuzaym
Nurse technician, Maternity and children hospital, Alahsa, Saudi Arabia.
Mukhtar muslim h bujubarah
Nursing specialist, Eradah Complex For Mental Health Dammam, Saudi Arabia.
Ahmed naser alzaher
Lab technician, Safwa General Hospital, Saudi Arabia.
Al Rashed, Ahmed Gaafar A
Laboratory specialist, Maternity and children hospital, Alahsa, Saudi Arabia.
Alamri, aljuri Ali m
Nurse, Taybah aljanubiah health center, Saudi Arabia.
Hanan Ahmed Mohammed Alzahrani
Nurse technician, Althager hospital, Saudi Arabia.
Salhah Ali Alshihri
Nurse specialist, Alaziziyah Children Hospital, Jeddah, Saudi Arabia.
Abdullah Ali Alamer
Nurse technician -operation room, Maternity and children hospital, Alahsa, Saudi Arabia.
Zahra yousef alnajadi
Nurse, King fahad hospital hofuf, Saudi Arabia.
Almuqadam,Jamilah Salem H
Nursing, Alaziziah children hospital, Saudi Arabia.
Alasiri saleh Abdulrahman
Pharmacist, KFMC Southern region, Saudi Arabia.
Ali Fayi Alabdali
Pharmacy technician, Rejal Almaa Health Sector, Saudi Arabia.
Assiri, Ibrahim Ali H
Prince Faisal Bin Khaled Cardiac center, Abha, Saudi Arabia.
Tariq meshal alshammari
Pharmacist technician, Maternity and children hospital Hail, Saudi Arabia.
Mohammed meshal Farhan
Pharmacy, king khalid hospital, MOH, Hail, Saudi Arabia.