COMPARATIVE STUDY OF COGNITIVE SYMPTOMS AND QUALITY OF LIFE IN PERSONS WITH EUTHYMIC BIPOLAR AFFECTIVE DISORDER: AN INDIAN STUDY
Main Article Content
Keywords
Euthymic, Bipolar, executive functions, cognitive symptoms
Abstract
Bipolar disorder (BD) is a long-lasting, recurrent affective disorder characterized by cyclic episodes of mania, hypomania and depression. Patients with bipolar disorder suffer from cognitive impairments not only during the acute phase but also during the remission phase, characterized by impairment of attention, memory and executive function. Aim of the study was to estimate group differences in attention concentration executive functions and quality of life in euthymic manic patients and first degree relatives of manic patients. 50 Euthymic patients (Bipolar-I Disorder, single manic episode, in full remission) 50 Euthymic patients (Bipolar-I Disorder, most recent episode manic, in full remission) First degree relatives of manic patients (n=50) and Control group (n=50) were selected for study. They were assessed on Young Mania rating scale, GHQ-12, Cognitive symptoms checklist, quality of life (WHOQOL) Brief. Results and Discussion are discussed below.
References
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22. Joe, S., Joo, Y., & Kim, S. (2008). Experience of subjective symptoms in euthymic patients with bipolar disorder. Journal of Korean medical science, 23(1), 18-23.
23. Kaya, E., Aydemir, Ö., & Selcuki, D. (2007). Residual symptoms in bipolar disorder: the effect of the last episode after remission. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31(7), 1387-1392.
24. Martínez‐Arán, A., Vieta, E., Colom, F., Torrent, C., Sánchez‐Moreno, J., Reinares, M., ... & Salamero, M. (2004). Cognitive impairment in euthymic bipolar patients: implications for clinical and functional outcome. Bipolar disorders, 6(3), 224-232.
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26. Michalak, E. E., Yatham, L. N., & Lam, R. W. (2005). Quality of life in bipolar disorder: a review of the literature. Health and quality of life outcomes, 3(1), 1-17.
27. Miskowiak, K. W., Burdick, K. E., Martinez‐Aran, A., Bonnin, C. M., Bowie, C. R., Carvalho, A. F., ... & Vieta, E. (2017). Methodological recommendations for cognition trials in bipolar disorder by the International Society for Bipolar Disorders Targeting Cognition Task Force. Bipolar Disorders, 19(8), 614-626.
28. Piccinni, A., Catena, M., Del Debbio, A., Marazziti, D., Monje, C., Schiavi, E., ... & Dell'Osso, L. (2007). Health-related quality of life and functioning in remitted bipolar I outpatients. Comprehensive psychiatry, 48(4), 323-328.
29. Porter, R. J., Robinson, L. J., Malhi, G. S., & Gallagher, P. (2015). The neurocognitive profile of mood disorders–a review of the evidence and methodological issues. Bipolar Disorders, 17, 21-40..
30. Reed, C., Goetz, I., Vieta, E., Bassi, M., & Haro, J. M. (2010). Work impairment in bipolar disorder patients–results from a two-year observational study (EMBLEM). European Psychiatry, 25(6), 338-344.
31. Robb, J. C., Cooke, R. G., Devins, G. M., Young, L. T., & Joffe, R. T. (1997). Quality of life and lifestyle disruption in euthymic bipolar disorder. Journal of psychiatric research, 31(5), 509-517.
32. Rocca, C. C., & Lafer, B. (2006). Neuropsychological disturbances in bipolar disorder. Revista Brasileira de Psiquiatria, 28(3), 226-237.
33. Rubinsztein, J. S., Michael, A., Paykel, E. S., & Sahakian, B. J. (2000). Cognitive impairment in remission in bipolar affective disorder. Psychological medicine, 30(5), 1025-1036.
34. Schneider, J. J., Candiago, R. H., Rosa, A. R., Ceresér, K. M., & Kapczinski, F. (2008). Cognitive impairment in a Brazilian sample of patients with bipolar disorder. Brazilian Journal of Psychiatry, 30, 209-214.
35. Sumiyoshi, T., Toyomaki, A., Kawano, N., Kitajima, T., Kusumi, I., Ozaki, N., ... & Nakagome, K. (2017). Verbal memory impairment in patients with subsyndromal bipolar disorder. Frontiers in Psychiatry, 8, 168.
36. Thompson, J. M., Gallagher, P., Hughes, J. H., Watson, S., Gray, J. M., Ferrier, I. N., & Young, A. H. (2005). Neurocognitive impairment in euthymic patients with bipolar affective disorder. The British Journal of Psychiatry, 186(1), 32-40.
37. Thompson, J. M., Gallagher, P., Hughes, J. H., Watson, S., Gray, J. M., Ferrier, I. N., & Young, A. H. (2005). Neurocognitive impairment in euthymic patients with bipolar affective disorder. Brazilian Journal of Psychiatry, 186, 32-40.
38. Thompson, J. M., Gray, J. M., Crawford, J. R., Hughes, J. H., Young, A. H., & Ferrier, I. N. (2009). Differential deficit in executive control in euthymic bipolar disorder. Journal of Abnormal Psychology, 118(1), 146-160.
39. Torres, I. J., DeFreitas, V. G., DeFreitas, C. M., Kauer-Sant, M., Bond, D. J., Honer, W. G., ... & Yatham, L. N. (2010). Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode. The Journal of clinical psychiatry, 71(9), 12653.
40. Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978). A rating scale for mania: reliability, validity and sensitivity. The British journal of psychiatry, 133(5), 429-435.
2. Basso, M. R., Lowery, N., Neel, J., Purdie, R., & Bornstein, R. A. (2002). Neuropsychological impairment among manic, depressed, and mixed-episode inpatients with bipolar disorder. Neuropsychology, 16(1), 84-91
3. Bearden, C. E., Glahn, D. C., Monkul, E. S., Barrett, J., Najt, P., Kaur, S., ... & Soares, J. C. (2006). Sources of declarative memory impairment in bipolar disorder: mnemonic processes and clinical features. Journal of psychiatric research, 40(1), 47-58.
4. Bearden, C.E., Hoffman, K.M., Cannon, T.D. (2001). The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review. Bipolar Disorders, 3(3), 126-140.
5. Bernstein, E. E., Rabideau, D. J., Gigler, M. E., Nierenberg, A. A., Deckersbach, T., & Sylvia, L. G. (2016). Patient perceptions of physical health and bipolar symptoms: The intersection of mental and physical health. Journal of affective disorders, 189, 203-206.
6. Bora, E., Yucel, M., & Pantelis, C. (2009). Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives. Journal of Affective Disorders, 113, 1-20.
7. Bezerra-Filho, S., Almeida, A. G. D., Studart, P., Rocha, M. V., Lopes, F. L., & Miranda-Scippa, Â. (2015). Personality disorders in euthymic bipolar patients: a systematic review. Brazilian Journal of Psychiatry, 37, 162-167.
8. Borges, L. J., Trentini, M. C., Bandeira, R. D., & DellÁglio, D. D. (2008). Neuropsychological assessment of psychological disorders in childhood: a review study. Psico-USF, 13(1), 125-133.
9. Burdick, K. E., Goldberg, J. F., Harrow, M., Faull, R. N., & Malhotra, A. K. (2006). Neurocognition as a stable endophenotype in bipolar disorder and schizophrenia. The Journal of nervous and mental disease, 194(4), 255-260.
10. Burdick, K. E., Gunawardane, N., Woodberry, K., & Malhotra, A. K. (2009). The role of general intelligence as an intermediate phenotype for neuropsychiatric disorders. Cognitive neuropsychiatry, 14(4-5), 299-311.
11. Burdick, K. E., Ketter, T. A., Goldberg, J. F., & Calabrese, J. R. (2015). Assessing cognitive function in bipolar disorder: challenges and recommendations for clinical trial design. The Journal of clinical psychiatry, 76(3), 1427.
12. Burdick, K.E., Gunawardane, N., Goldberg, J. F., Halperin, J. M., Garno, J. L., & Malhotra, A. K. (2009). Attention and psychomotor functioning in bipolar depression. Psychiatric Research, 166 (2-3), 192-200.
13. Chaves, O. C., Lombardo, L. E., Bearden, C. E., Woolsey, M. D., Martinez, D. M., Barrett, J. A., ... & Glahn, D. C. (2011). Association of clinical symptoms and neurocognitive performance in bipolar disorder: a longitudinal study. Bipolar disorders, 13(1), 118-123.
14. Clark, L., Kempton, M. J., Scarnà, A., Grasby, P. M., & Goodwin, G. M. (2005). Sustained attention-deficit confirmed in euthymic bipolar disorder but not in first-degree relatives of bipolar patients or euthymic unipolar depression. Biological psychiatry, 57(2), 183-187.
15. Cullen, B., Ward, J., Graham, N. A., Deary, I. J., Pell, J. P., Smith, D. J., & Evans, J. J. (2016). Prevalence and correlates of cognitive impairment in euthymic adults with bipolar disorder: a systematic review. Journal of affective disorders, 205, 165-181.
16. Dittmann, S., Hennig‐Fast, K., Gerber, S., Seemüller, F., Riedel, M., Emanuel Severus, W., ... & Grunze, H. C. (2008). Cognitive functioning in euthymic bipolar I and bipolar II patients. Bipolar disorders, 10(8), 877-887.
17. Gazalle, F. K., Hallal, P. C., Andreazza, A. C., Frey, B. N., Kauer-Sant'Anna, M., Weyne, F., ... & Kapczinski, F. (2007). Manic symptoms and quality of life in bipolar disorder. Psychiatry research, 153(1), 33-38.
18. Glahn, D. C., Bearden, C. E., Barguil, M., Barrett, J., Reichenberg, A., Bowden, C. L., ... & Velligan, D. I. (2007). The neurocognitive signature of psychotic bipolar disorder. Biological psychiatry, 62(8), 910-916.
19. Goldberg, D. P., & Hillier, V. F. (1979). A scaled version of the General Health Questionnaire. Psychological medicine, 9(1), 139-145.
20. Goldberg, J. F., & Burdick, K. (Eds.). (2009). Cognitive dysfunction in bipolar disorder: a guide for clinicians. American Psychiatric Pub.
21. Harper, A., & Power, M. (1999). WHOQOL User manual. World Health Organization Edinburgh.
22. Joe, S., Joo, Y., & Kim, S. (2008). Experience of subjective symptoms in euthymic patients with bipolar disorder. Journal of Korean medical science, 23(1), 18-23.
23. Kaya, E., Aydemir, Ö., & Selcuki, D. (2007). Residual symptoms in bipolar disorder: the effect of the last episode after remission. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31(7), 1387-1392.
24. Martínez‐Arán, A., Vieta, E., Colom, F., Torrent, C., Sánchez‐Moreno, J., Reinares, M., ... & Salamero, M. (2004). Cognitive impairment in euthymic bipolar patients: implications for clinical and functional outcome. Bipolar disorders, 6(3), 224-232.
25. Martino, D. J., Strejilevich, S. A., Torralva, T., & Manes, F. (2010). Decision making in euthymic bipolar I and bipolar II disorders. Psychological Medicine, 41, 1319-1327.
26. Michalak, E. E., Yatham, L. N., & Lam, R. W. (2005). Quality of life in bipolar disorder: a review of the literature. Health and quality of life outcomes, 3(1), 1-17.
27. Miskowiak, K. W., Burdick, K. E., Martinez‐Aran, A., Bonnin, C. M., Bowie, C. R., Carvalho, A. F., ... & Vieta, E. (2017). Methodological recommendations for cognition trials in bipolar disorder by the International Society for Bipolar Disorders Targeting Cognition Task Force. Bipolar Disorders, 19(8), 614-626.
28. Piccinni, A., Catena, M., Del Debbio, A., Marazziti, D., Monje, C., Schiavi, E., ... & Dell'Osso, L. (2007). Health-related quality of life and functioning in remitted bipolar I outpatients. Comprehensive psychiatry, 48(4), 323-328.
29. Porter, R. J., Robinson, L. J., Malhi, G. S., & Gallagher, P. (2015). The neurocognitive profile of mood disorders–a review of the evidence and methodological issues. Bipolar Disorders, 17, 21-40..
30. Reed, C., Goetz, I., Vieta, E., Bassi, M., & Haro, J. M. (2010). Work impairment in bipolar disorder patients–results from a two-year observational study (EMBLEM). European Psychiatry, 25(6), 338-344.
31. Robb, J. C., Cooke, R. G., Devins, G. M., Young, L. T., & Joffe, R. T. (1997). Quality of life and lifestyle disruption in euthymic bipolar disorder. Journal of psychiatric research, 31(5), 509-517.
32. Rocca, C. C., & Lafer, B. (2006). Neuropsychological disturbances in bipolar disorder. Revista Brasileira de Psiquiatria, 28(3), 226-237.
33. Rubinsztein, J. S., Michael, A., Paykel, E. S., & Sahakian, B. J. (2000). Cognitive impairment in remission in bipolar affective disorder. Psychological medicine, 30(5), 1025-1036.
34. Schneider, J. J., Candiago, R. H., Rosa, A. R., Ceresér, K. M., & Kapczinski, F. (2008). Cognitive impairment in a Brazilian sample of patients with bipolar disorder. Brazilian Journal of Psychiatry, 30, 209-214.
35. Sumiyoshi, T., Toyomaki, A., Kawano, N., Kitajima, T., Kusumi, I., Ozaki, N., ... & Nakagome, K. (2017). Verbal memory impairment in patients with subsyndromal bipolar disorder. Frontiers in Psychiatry, 8, 168.
36. Thompson, J. M., Gallagher, P., Hughes, J. H., Watson, S., Gray, J. M., Ferrier, I. N., & Young, A. H. (2005). Neurocognitive impairment in euthymic patients with bipolar affective disorder. The British Journal of Psychiatry, 186(1), 32-40.
37. Thompson, J. M., Gallagher, P., Hughes, J. H., Watson, S., Gray, J. M., Ferrier, I. N., & Young, A. H. (2005). Neurocognitive impairment in euthymic patients with bipolar affective disorder. Brazilian Journal of Psychiatry, 186, 32-40.
38. Thompson, J. M., Gray, J. M., Crawford, J. R., Hughes, J. H., Young, A. H., & Ferrier, I. N. (2009). Differential deficit in executive control in euthymic bipolar disorder. Journal of Abnormal Psychology, 118(1), 146-160.
39. Torres, I. J., DeFreitas, V. G., DeFreitas, C. M., Kauer-Sant, M., Bond, D. J., Honer, W. G., ... & Yatham, L. N. (2010). Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode. The Journal of clinical psychiatry, 71(9), 12653.
40. Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978). A rating scale for mania: reliability, validity and sensitivity. The British journal of psychiatry, 133(5), 429-435.
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Dec 10, 2022
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Dr Lalit Kumar Singh, & Dr Kiran Srivastava. (2022). COMPARATIVE STUDY OF COGNITIVE SYMPTOMS AND QUALITY OF LIFE IN PERSONS WITH EUTHYMIC BIPOLAR AFFECTIVE DISORDER: AN INDIAN STUDY. Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 2375-2382. https://doi.org/10.53555/jptcp.v29i04.5389
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Author Biographies
Dr Lalit Kumar Singh
Assistant Professor, PGIMER, Chandigarh
Dr Kiran Srivastava
AssociateProfessor, Chandigarh University
How to Cite
Dr Lalit Kumar Singh, & Dr Kiran Srivastava. (2022). COMPARATIVE STUDY OF COGNITIVE SYMPTOMS AND QUALITY OF LIFE IN PERSONS WITH EUTHYMIC BIPOLAR AFFECTIVE DISORDER: AN INDIAN STUDY. Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 2375-2382. https://doi.org/10.53555/jptcp.v29i04.5389