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Arif Kibzai
Mehvish Mandokhail
Sanaullah Jamali
Zulfiqar Mandokhail
Sara Mandokhel
Ubaid Ullah
Mubina Aziz


Neonatal sepsis, Neonatal intensive care unit, Bacteriological profile, Antimicrobial susceptibility



Background: Neonatal sepsis, described as a systemic infection occurring inside the first month of life, remains a main cause of morbidity and mortality in neonatal intensive care units (NICUs) globally, posing extensive challenges to healthcare professionals and families.

Objective: This study aimed to investigate the bacteriological profile and antimicrobial susceptibility patterns of neonatal sepsis in the NICU of Combine Military Hospital (CMH), analyzing data from 105 patients.

Study Design: A retrospective study.

Duration and Place of a Study: This study was conducted at the Neonatal Intensive Care Unit (NICU) of Combine Military Hospital (CMH), Quetta, between February 2022 to February 2023.

Material and Methods: The study population comprised neonates admitted to the NICU for the study period who met the inclusion standards for suspected neonatal sepsis. Neonates with clinical symptoms suggestive of sepsis, including temperature instability, respiratory distress, feeding difficulties, lethargy, or abnormal laboratory parameters, were included in the study. Clinical and demographic data, which provides for gestational age, birth weight, mode of delivery, prenatal history, postnatal course, laboratory results, and antibiotic therapy, were retrieved from electronic clinical records and patient charts.

Results: The study included 105 neonates with suspected sepsis. The majority of the neonates were male (52.4%) and were born between 33-36 weeks of gestation (33.3%). The most common birth weight range turned into 1501-2500 grams (38.1%). Vaginal delivery was the most common mode of delivery (47.6%), followed by means of cesarean section (42.9%).

Conclusion: This study provides precious insights into the demographic and clinical characteristics of neonates with suspected sepsis.


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