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Hina Yasin
Shaukat Mahmud
Hina Abrar
Kaneez Fatima
Hina Tabassum
Asma Basharat Ali


Croton bonplandianus, bark extract, Pharmacological analysis, anti-cancer potential, Male albino mice, Male albino rats wistar strain


Plants are the ultimate inevitability of planet and for the mankind and animal kingdom. Herbal plant not only source of nutrition however used as remedy from ancient period. The main goal of this study is to provide a platform for researchers to examine the potential health benefits of plant extracts across a range of illness states. The bark of the plant Croton bonplandianus were selected for this research study. Different pharmacological activities such as analgesic, anti-inflammatory, antifungal, antibacterial, anticancer, hepatoprotective and nephroprotective activities were performed followed by histopathological studies and brine shrimp bioassay to evaluate the therapeutic and toxic potential of different extracts of bark. The histopathological screening was reported to strengthen the pharmacological studies regarding the safety profile of extracts of the bark of the Croton bonplandianus. The results revealed that the various plant extracts were shown significant dose dependent analgesic activity and potentially nephroprotective and hepatoprotective may be due to the presence of antioxidant flavonoids and phytosteroides. Three distinct cancer cell lines were selected for estimation of cytotoxic activity and the results shown mild to moderate activity. Antibacterial and antifungal activities were also performed by MABA assay and agar tube dilution method respectively. Aforementioned research opens an unlimited access for the investigation of therapeutically active constituents, isolation of pure compounds and preclinical and clinical studies. Furthermore, extensive research in the several directions must be escorted to discover the new drug molecules that may be used as a raw material in the pharmaceutical industries.

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