IMPACT OF IRON OVERLOAD AND HAMETOLOGICAL IN TRANSFUSION DEPENDENT THALSSEMIA PATIENTS

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Dildar Ali Solangi
Naseem Aslam Chann
Allah Bachayo Rajar
Aneel Kapoor
Irshad Chandio
Ghulam Serwar Shaikh
Abdul Hameed Lanjwani
Vinay Kumar Jesrani

Keywords

Iron overload, renal chemistry, transfusion, thalassemia.

Abstract

Background: In order to investigate the demographic, hematological and renal failure variables that affect TDT patients in Hyderabad and adjacent regions, the current study was conducted. 


Methods:  A total of 142 individuals were interviewed throughout the research period, comprising 71 TDT patients and 71 control subjects (age and gender matched with no personal or family history of blood disorders). Serum ferritin, hepatitis C and B, blood groups, hematological parameters, complete blood count have been compared with control groups. 


Results: When comparing TDT patients to the control group, we discovered that their serum haemoglobin (HB), mean corpuscular value (MCV), or mean corpuscular hemoglobin (MCH). In contrast to male control participants, red blood cells (RBC), HB, HCT, and MCV were shown to be considerably increased (p<0.05) in male patients and dramatically decreased (p<0.05) in both genders. It is a significant serum creatinine level was noted high among 5-10 years and 11-15 years in comparison to all other age groups. the higher level of serum urea at the age of 4-10 years and non-significant variation (p>0.05) was found among all other age groups of TDT patients.


Conclusions: Transfusion-related blood abnormalities in TDT patients include iron excess and its repercussions, which include injury to the kidneys and spleen. TDT patients also frequently have hepatic viral infections. It is important for medical professionals to carefully monitor and treat patients in order to lessen their suffering and help them return to a balanced way of life. 

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