COMPARISON OF PREGABLIN VERSUS PLACEBO FOR POSTOPERATIVE PAIN IN PATIENTS UNDERGOING LOWER LIMB SURGERY

Main Article Content

Dr Mamoona Shaikh
Dr Maria Karim Narejo
Dr Jamil Ahmed
Dr Kauser Shaikh

Keywords

Postoperative pain, Lower limb surgery of Tibia/femur, Opioids, pregablin

Abstract

Objectives: To compare the postoperative outcomes of pregablin versus placebo in patients undergoing Lower limb surgery.


Materials and Methods:  In this RCT study, we enrolled a total of 100 patients, undergoing elective lower limb surgery of Tibia/femur. Patients were divided into two groups. Group I was offered Pregablin and Group II was given Placebo.  Pain was assessed on VAS scale and at 2 score 4 and above IV pethidine 50 mg was given. At 24 hours pain was assessed finally and consumption of opioid was noted in the proforma by the PI.


Results: The average age of the patients was 39.08±8.81years. Mean pain score was significantly high in group II than Group I [4.7±1.39 vs. 2.52±0.99; p=0.0005]. Mean Opioid consumption was significantly high in group II as compare to group I [91.22±42.92 vs. 55.56±16.67; p=0.019].


Conclusion: Administering a single preoperative oral dose of 150 mg pregabalin has been demonstrated as an effective approach in mitigating postoperative pain among individuals undergoing lower limb surgery.

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