FREQUENCY OF HYPERURICEMIA IN HYPERTENSIVE PATIENTS: A DESCRIPTIVE CROSS-

Main Article Content

Dr Devanand
Dr Muhammad Shahid
Dr Sadia Mansoor
Dr Waqqas Ishaq
Dr Syed Faisal Hussain
Dr Fahad Asim

Keywords

Hyperuricemia, Hypertensive, Female

Abstract

Objectives: To determine the frequency of Hyperuricemia in Hypertensive Patients.


Materials and Methods:  This cross-sectional study was conducted at multiple centers including Chaudhry Pervaiz Elahi Institute of Cardiology, Wazirabad and Jinnah Sindh Medical University, Karachi from July, 2023 to December, 2023. A total of 310 patients who met the inclusion criteria were included in the study. A trained phlebotomist collected 5 ml of blood from each patient, which was then sent to the laboratory for analysis of serum uric acid levels. Patients with fasting serum uric acid levels equal to or greater than 7.0 mg/dL were classified as having hyperuricemia.


Results: The mean age of all patients was 52.93 years, with the majority (55.5%) falling within the 56-70 age group. The 41-55 age group accounted for 25.8% of patients, while the 25-40 age group had the lowest representation at 25.8%. Among the total 310 enrolled patients with hypertension, hyperuricemia was observed in 125 (40.3%) individuals. Gender distribution revealed 127 (41.0%) male patients and 183 (59.0%) female patients. Further analysis involved stratifying hyperuricemia by gender and age groups. However, this analysis yielded an insignificant p-value.


Conclusion: The study concluded that hyperuricemia was associated with hypertension. Additionally, it found that in later stages of life, female individuals with hypertension are more susceptible to experiencing hyperuricemia compared to males.


 

Abstract 130 | PDF Downloads 65

References

1. Ansari RN, Gandhi RV, Saiyed M, Jain KD. Study of prevalence and impact of hyperuricemia in a patient of hypertension. Int J Adv Med. 2017;4(2):367.
2. Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The lancet. 2012;380(9859):2224-60.
3. Aasif M, Chitkara E. Uric acid in relation to Type 2 diabetes.
4. Richet G. The chemistry of urinary stones around 1800: a first in clinical chemistry. Kidney international. 1995;48(3):876-86.
5. Adomako E, Moe OW, editors. Uric acid and urate in urolithiasis: the innocent bystander, instigator, and perpetrator. Seminars in nephrology; 2020: Elsevier.
6. Jin M, Yang F, Yang I, Yin Y, Luo JJ, Wang H, et al. Uric acid, hyperuricemia and vascular diseases. Frontiers in bioscience: a journal and virtual library. 2012;17:656.
7. Muszyński P, Dąbrowski EJ, Pasławska M, Niwińska M, Kurasz A, Święczkowski M, et al., editors. Hyperuricemia as a risk factor in hypertension among patients with very high cardiovascular risk. Healthcare; 2023: MDPI.
8. Bilal MH, Tahir M. Frequency of hyperuricemia in hypertensive patients presenting at DG Khan Hospital, DG Khan. Pak J Med Health Sci. 2015;9(2):547-49.
9. Sharma P, Singh P, Bhinda A. Hyperuricemia: a systemic review. World J Pharm Res. 2021;10(01):911-22.
10. Stewart DJ, Langlois V, Noone D. Hyperuricemia and hypertension: links and risks. Integrated blood pressure control. 2019:43-62.
11. Chen Y-Y, Kao T-W, Yang H-F, Chou C-W, Wu C-J, Lai C-H, et al. The association of uric acid with the risk of metabolic syndrome, arterial hypertension or diabetes in young subjects-an observational study. Clinica Chimica Acta. 2018;478:68-73.
12. Anand N, Padma V, Prasad A, Alam KC, Javid MSM. Serum uric acid in new and recent onset primary hypertension. Journal of Pharmacy & Bioallied Sciences. 2015;7(Suppl 1):S4.
13. Kanellis J, Kang D-H, editors. Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Seminars in nephrology; 2005: Elsevier.
14. El Din UAS, Salem MM, Abdulazim DO. Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: a review. Journal of advanced research. 2017;8(5):537-48.
15. Shaikh AA, Altaf A. Prevalence of hyperuricemia in Sukkur; Pakistan: A cross sectional survey. The Professional Medical Journal. 2019;26(09):1567-9.
16. Afifi A, Sarhan I, El Sharkawy M, Kamel M, Anwar W, Helmy N, et al. Uric acid metabolism in a sample of Egyptian hypertensive patients with normal kidney function. The Egyptian Journal of Hospital Medicine. 2013;52(1):608-14.
17. Rehman A, Sattar A, Abaidullah S, HASAN M. Evaluation of Cardiovascular Risk Factors in Patients with Essential Hypertension. Annals of King Edward Medical University. 1999;5(2):134-7.
18. Ahmed N, Anwar W, Waqas H. Obesity, hyperlipidemia, and hyperuraecemia in young and old hypertensive patients. Journal of Ayub Medical College Abbottabad. 2009;21(4):53-6.