THE EFFECTIVENESS AND SAFETY OF SILVER DIAMINE FLUORIDE ON PRIMARY TEETH: A REVIEW OF LITERATURE
Main Article Content
Keywords
Silver Diamine Fluoride, SDF, SDF effectiveness, SDF Safety, Children, Primary teeth, Arrest dental caries.
Abstract
Silver diamine fluoride (SDF) is a potent compound for the arrest of dental caries in pediatric populations, demonstrating ease of application and the capacity for utilization beyond traditional clinical contexts. The aim of this study was to perform a literature review on the effectiveness and safety of SDF in arresting dental caries in primary teeth of young children. A literature review was conducted using the Old Dominion University library resources. Utilizing the established search methodology, A comprehensive total of 57 studies were identified across all relevant databases; however, only 13 were clinical trials that specifically evaluated the effectiveness and safety of SDF treatments. The remaining 44 studies were mostly surveys or irrelevant to the effectiveness and safety of SDF, often with titles that did not accurately represent the content of the studies, and primarily focused on parental acceptance of SDF treatments for their children. In general, the findings demonstrated SDF to be effective in arresting dental caries in deciduous teeth relative to alternative approaches, such as fluoride varnish and atraumatic restorative treatment (ART). Additionally, the prevailing evidence substantiates the safety of SDF application in pediatric populations. The drawback of SDF application is the induction of dark discoloration on the treated, caries-arrested tooth.
References
1. National Institute of Dental and Craniofacial Research. (2018). Dental caries (tooth decay). https://www.nidcr.nih.gov/research/data- statistics/dental-caries
2. Centers for Disease Control and Prevention. (2019). Oral health surveillance report: Trends in dental caries and sealants, tooth retention, and edentulism, United States, 1999–2004 to 2011–2016. https://www.cdc.gov/oralhealth/publications/OHSR-2019-dental-caries-primary-teeth. html
3. U.S. Department of Health and Human Services. (2020). Reduce the proportion of children and adolescents with active and untreated tooth decay — OH02 - Healthy People 2030. https://health.gov/healthypeople/objectives-and- data/browse-objectives/oral-conditions/reduce- proportion-children-and-adolescents-active-and- untreated-tooth-decay-oh-02
4. U.S. Department of Health and Human Services. (2020). Reduce the proportion of children and adolescents with lifetime tooth decay — OH01 – Healthy People 2030. https://health.gov/healthypeople/objectives-and- data/browse-objectives/oral-conditions/reduce- proportion-children-and-adolescents-lifetime-tooth- decay-oh-01
5. G. Bridge, A. S. Martel, M. Lomazzi. (2021). Silver diamine fluoride: transforming community dental caries program. International dental journal. 71 (6): e458-e461.
6. J. Clemens, J. Gold, J. Chaffin. (2018). Effect and acceptance of silver diamine fluoride treatment on dental caries in primary teeth. Journal of public health dentistry. 78 (1): e63-e68.
7. American Academy of Pediatric Dentistry. (2018). Policy on the dental home. Retrieved from https://www.aapd.org/globalassets/media/policies_ guidelines/p_dentalhome.pdf
8. M. J. Coppes, S. A. Fisher-Owens. (2018). Oral Health in Children, An Issue of Pediatric Clinics of North America. 65 (5).
9. National Center for Health Statistics. (2021). Use of dental services among children and adolescents aged 2–17 years, by selected characteristics: United States, selected years 1997–2019. Health, United States, 2020. Retrieved from https://www.cdc.gov/nchs/data/hus/2020- 2021/DentCh.pdf
10. American Dental Association. (2021) Silver diamine fluoride. Science & Research Institute: Oral Health Topics. Retrieved from https://www.ada.org/resources/research/science-and-research-institute/oral-health-topics/silver- diamine-fluoride
11. Y. O. Crystal, R. Niederman. (2019). Evidence- based dentistry update on silver diamine fluoride. Dental Clinics. 63 (1): e45-e68.
12. D. Duangthip, M. H. T. Fung, M. C. M. Wong, C. H. Chu, E. C. M. Lo. (2018). Adverse effects of silver diamine fluoride treatment among preschool children. Journal of dental research. 97 (4): e395- e401.
13. H. Ellenikiotis, K. F. Chen, D. N. Soleimani- Meigooni, M. L. Rothen, B. Thompson, Y. S. Lin, P. Milgrom. (2022). Pharmacokinetics of 38 percent silver diamine fluoride in children. Pediatric Dentistry. 44 (2): e114-e121.
14. M. Nishino, S. Yoshida, S. Sobue, J. Kato, M. Nishida. (1969). Effect of topically applied ammoniacal silver fluoride on dental caries in children. The Journal of Osaka University Dental School. 9 (1): e149-e155.
15. R. Yamaga. (1972). Diamine silver fluoride and its clinical application. The Journal of Osaka University Dental School. 12 (1): e1-e20.
16. J. A. Horst, H. Ellenikiotis, P. L. Milgrom. (2016). UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent. Journal of the California Dental Association. 44 (1): e16-e28.
17. Q. H. Zhi, E. C. M. Lo, H. C. Lin. (2012). Randomized clinical trial on effectiveness of silver diamine fluoride and glass ionomer in arresting dentine caries in preschool children. Journal of dentistry. 40 (11): e962-e967.
18. S. Gao, K. Chen, D. Duangthip, M. Wong, E. Chin, C. Chu. (2020). Arresting early childhood caries using silver and fluoride products - A randomized trial. The Journal of Dentistry. 103 (103522).
19. D. Duangthip, C. H. Chu, E. C. M. Lo. (2016). A randomized clinical trial on arresting dentine caries in preschool children by topical fluorides—18- month results. Journal of Dentistry. 44 (1): e57-e63.
20. S. Mabangkhru, D. Duangthip, C. Chu, A. Phonghanyudh a, V. Jirarattanasopha. (2020). A randomized clinical trial to arrest dentin caries in young children using silver diamine fluoride. Journal of Dentistry. 99 (1).
21. C. H. Chu, E. C. M. Lo, H. C. Lin. (2002). Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children. Journal of Dental Research. 81 (11): e767-e770.
22. R. Yee, C. Holmgren, J. Mulder, D. Lama, D. Walker, W. van Palenstein Helderman. (2009). Efficacy of silver diamine fluoride for arresting caries treatment. Journal of Dental Research. 88 (7): e644-e647.
23. A. Phonghanyudh, D. Duangthip, S. Mabangkhru, V. Jirarattanasopha. (2022). Is Silver Diamine Fluoride Effective in Arresting Enamel Caries? A Randomized Clinical Trial. International Journal of Environmental Research and Public Health. 19 (15): e8992.
24. D. Satyarup, S. Mohanty, R. Nagarajappa, I. Mahapatra, R. P. Dalai. (2022). Comparison of the effectiveness of 38% silver diamine fluoride and atraumatic restorative treatment for treating dental caries in a school setting: A randomized clinical trial. Dental and Medical Problems. 59 (2): e217- e223.
25. H. M. Abdellatif, A. M. Ali, S. I. Baghdady, M. A. ElKateb. (2021). Caries arrest effectiveness of silver diamine fluoride compared to alternative restorative technique: randomized clinical trial. European Archives of Paediatric Dentistry. 1 (1): e1-e11.
26. J. Cleary, R. Al-Hadidi, A. Scully, W. Yahn, Z. Zaid, J. R. Boynton, G. J. Eckert, E. Yanca, M. Fontana. (2022). A 12-Month Randomized Clinical Trial of 38% SDF vs. Restorative Treatment. JDR Clinical and Translational Research. 7 (2): e135- e144.
27. P. Milgrom, J. A. Horst, S. Ludwig, M. Rothen, B. W. Chaffee, S. Lyalina, L. Mancl. (2018). Topical silver diamine fluoride for dental caries arrest in preschool children: A randomized controlled trial and microbiological analysis of caries associated microbes and resistance gene expression. Journal of Dentistry. 68 (1): e72-e78.
28. R. L. Slayton, O. Urquhart, M. W. B. Araujo, M. Fontana, S. Guzmán-Armstrong, M. M. Nascimento, B. B. Nový, N. Tinanoff, R. J. Weyant, bM. S. Wolff, D. A. Young, D. T. Zero, M. P. Tampi, L. Pilcher, L. Banfield, A. Carrasco-Labra. (2018). Evidence-based clinical practice guideline on nonrestorative treatments for carious lesions: A report from the American Dental Association. Journal of the American Dental Association (1939). 149 (10): e837-e849American Dental Hygienists' Association. (2021).
29. Silver Diamine Fluoride State-by-State Information. https://www.adha.org/wpcontent/ uploads/2022/12/ Silver_Diamine_Fluoride_State_by_State_Informat ion.pdf
30. A. Rosenblatt, T. C. M. Stamford, R. Niederman. (2009). Silver Diamine Fluoride: A Caries "Silver- Fluoride Bullet". Journal of Dental Research. 88 (2): e116-e125.
31. American Dental Hygienists' Association. (2021). Silver Diamine Fluoride State-by-State Information. https://www.adha.org/wp-content/uploads/2022/12/Silver_Diamine_Fluoride_ State_by_State_Information.pdf
32. Association of State and Territorial Dental Directors. (2017). Silver Diamine Fluoride: A resource for decision-making. https://www.astdd.org/www/docs/sdf-fact-sheet-09-07-201
2. Centers for Disease Control and Prevention. (2019). Oral health surveillance report: Trends in dental caries and sealants, tooth retention, and edentulism, United States, 1999–2004 to 2011–2016. https://www.cdc.gov/oralhealth/publications/OHSR-2019-dental-caries-primary-teeth. html
3. U.S. Department of Health and Human Services. (2020). Reduce the proportion of children and adolescents with active and untreated tooth decay — OH02 - Healthy People 2030. https://health.gov/healthypeople/objectives-and- data/browse-objectives/oral-conditions/reduce- proportion-children-and-adolescents-active-and- untreated-tooth-decay-oh-02
4. U.S. Department of Health and Human Services. (2020). Reduce the proportion of children and adolescents with lifetime tooth decay — OH01 – Healthy People 2030. https://health.gov/healthypeople/objectives-and- data/browse-objectives/oral-conditions/reduce- proportion-children-and-adolescents-lifetime-tooth- decay-oh-01
5. G. Bridge, A. S. Martel, M. Lomazzi. (2021). Silver diamine fluoride: transforming community dental caries program. International dental journal. 71 (6): e458-e461.
6. J. Clemens, J. Gold, J. Chaffin. (2018). Effect and acceptance of silver diamine fluoride treatment on dental caries in primary teeth. Journal of public health dentistry. 78 (1): e63-e68.
7. American Academy of Pediatric Dentistry. (2018). Policy on the dental home. Retrieved from https://www.aapd.org/globalassets/media/policies_ guidelines/p_dentalhome.pdf
8. M. J. Coppes, S. A. Fisher-Owens. (2018). Oral Health in Children, An Issue of Pediatric Clinics of North America. 65 (5).
9. National Center for Health Statistics. (2021). Use of dental services among children and adolescents aged 2–17 years, by selected characteristics: United States, selected years 1997–2019. Health, United States, 2020. Retrieved from https://www.cdc.gov/nchs/data/hus/2020- 2021/DentCh.pdf
10. American Dental Association. (2021) Silver diamine fluoride. Science & Research Institute: Oral Health Topics. Retrieved from https://www.ada.org/resources/research/science-and-research-institute/oral-health-topics/silver- diamine-fluoride
11. Y. O. Crystal, R. Niederman. (2019). Evidence- based dentistry update on silver diamine fluoride. Dental Clinics. 63 (1): e45-e68.
12. D. Duangthip, M. H. T. Fung, M. C. M. Wong, C. H. Chu, E. C. M. Lo. (2018). Adverse effects of silver diamine fluoride treatment among preschool children. Journal of dental research. 97 (4): e395- e401.
13. H. Ellenikiotis, K. F. Chen, D. N. Soleimani- Meigooni, M. L. Rothen, B. Thompson, Y. S. Lin, P. Milgrom. (2022). Pharmacokinetics of 38 percent silver diamine fluoride in children. Pediatric Dentistry. 44 (2): e114-e121.
14. M. Nishino, S. Yoshida, S. Sobue, J. Kato, M. Nishida. (1969). Effect of topically applied ammoniacal silver fluoride on dental caries in children. The Journal of Osaka University Dental School. 9 (1): e149-e155.
15. R. Yamaga. (1972). Diamine silver fluoride and its clinical application. The Journal of Osaka University Dental School. 12 (1): e1-e20.
16. J. A. Horst, H. Ellenikiotis, P. L. Milgrom. (2016). UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent. Journal of the California Dental Association. 44 (1): e16-e28.
17. Q. H. Zhi, E. C. M. Lo, H. C. Lin. (2012). Randomized clinical trial on effectiveness of silver diamine fluoride and glass ionomer in arresting dentine caries in preschool children. Journal of dentistry. 40 (11): e962-e967.
18. S. Gao, K. Chen, D. Duangthip, M. Wong, E. Chin, C. Chu. (2020). Arresting early childhood caries using silver and fluoride products - A randomized trial. The Journal of Dentistry. 103 (103522).
19. D. Duangthip, C. H. Chu, E. C. M. Lo. (2016). A randomized clinical trial on arresting dentine caries in preschool children by topical fluorides—18- month results. Journal of Dentistry. 44 (1): e57-e63.
20. S. Mabangkhru, D. Duangthip, C. Chu, A. Phonghanyudh a, V. Jirarattanasopha. (2020). A randomized clinical trial to arrest dentin caries in young children using silver diamine fluoride. Journal of Dentistry. 99 (1).
21. C. H. Chu, E. C. M. Lo, H. C. Lin. (2002). Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children. Journal of Dental Research. 81 (11): e767-e770.
22. R. Yee, C. Holmgren, J. Mulder, D. Lama, D. Walker, W. van Palenstein Helderman. (2009). Efficacy of silver diamine fluoride for arresting caries treatment. Journal of Dental Research. 88 (7): e644-e647.
23. A. Phonghanyudh, D. Duangthip, S. Mabangkhru, V. Jirarattanasopha. (2022). Is Silver Diamine Fluoride Effective in Arresting Enamel Caries? A Randomized Clinical Trial. International Journal of Environmental Research and Public Health. 19 (15): e8992.
24. D. Satyarup, S. Mohanty, R. Nagarajappa, I. Mahapatra, R. P. Dalai. (2022). Comparison of the effectiveness of 38% silver diamine fluoride and atraumatic restorative treatment for treating dental caries in a school setting: A randomized clinical trial. Dental and Medical Problems. 59 (2): e217- e223.
25. H. M. Abdellatif, A. M. Ali, S. I. Baghdady, M. A. ElKateb. (2021). Caries arrest effectiveness of silver diamine fluoride compared to alternative restorative technique: randomized clinical trial. European Archives of Paediatric Dentistry. 1 (1): e1-e11.
26. J. Cleary, R. Al-Hadidi, A. Scully, W. Yahn, Z. Zaid, J. R. Boynton, G. J. Eckert, E. Yanca, M. Fontana. (2022). A 12-Month Randomized Clinical Trial of 38% SDF vs. Restorative Treatment. JDR Clinical and Translational Research. 7 (2): e135- e144.
27. P. Milgrom, J. A. Horst, S. Ludwig, M. Rothen, B. W. Chaffee, S. Lyalina, L. Mancl. (2018). Topical silver diamine fluoride for dental caries arrest in preschool children: A randomized controlled trial and microbiological analysis of caries associated microbes and resistance gene expression. Journal of Dentistry. 68 (1): e72-e78.
28. R. L. Slayton, O. Urquhart, M. W. B. Araujo, M. Fontana, S. Guzmán-Armstrong, M. M. Nascimento, B. B. Nový, N. Tinanoff, R. J. Weyant, bM. S. Wolff, D. A. Young, D. T. Zero, M. P. Tampi, L. Pilcher, L. Banfield, A. Carrasco-Labra. (2018). Evidence-based clinical practice guideline on nonrestorative treatments for carious lesions: A report from the American Dental Association. Journal of the American Dental Association (1939). 149 (10): e837-e849American Dental Hygienists' Association. (2021).
29. Silver Diamine Fluoride State-by-State Information. https://www.adha.org/wpcontent/ uploads/2022/12/ Silver_Diamine_Fluoride_State_by_State_Informat ion.pdf
30. A. Rosenblatt, T. C. M. Stamford, R. Niederman. (2009). Silver Diamine Fluoride: A Caries "Silver- Fluoride Bullet". Journal of Dental Research. 88 (2): e116-e125.
31. American Dental Hygienists' Association. (2021). Silver Diamine Fluoride State-by-State Information. https://www.adha.org/wp-content/uploads/2022/12/Silver_Diamine_Fluoride_ State_by_State_Information.pdf
32. Association of State and Territorial Dental Directors. (2017). Silver Diamine Fluoride: A resource for decision-making. https://www.astdd.org/www/docs/sdf-fact-sheet-09-07-201
Article Sidebar
Published
Nov 25, 2022
Article Details
How to Cite
Ali Mahdi S Alsalem, Dr. Abdullah Mohammed Al-Qedrah, & Abdullah Ali S Alharith. (2022). THE EFFECTIVENESS AND SAFETY OF SILVER DIAMINE FLUORIDE ON PRIMARY TEETH: A REVIEW OF LITERATURE. Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 1983-1999. https://doi.org/10.53555/jptcp.v29i04.5008
Section
Articles
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Author Biographies
Ali Mahdi S Alsalem
Dental Hygiene Specialist , Ministry of Health, Saudi Arabia
Dr. Abdullah Mohammed Al-Qedrah
Endodontics Consultant, Ministry of Health, Saudi Arabia
Abdullah Ali S Alharith
Dental Lab Specialist, Ministry of Health, Saudi Arabia
How to Cite
Ali Mahdi S Alsalem, Dr. Abdullah Mohammed Al-Qedrah, & Abdullah Ali S Alharith. (2022). THE EFFECTIVENESS AND SAFETY OF SILVER DIAMINE FLUORIDE ON PRIMARY TEETH: A REVIEW OF LITERATURE. Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 1983-1999. https://doi.org/10.53555/jptcp.v29i04.5008