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Dr Kulsoom Lashari
Dr Muhammad Ilyas
Dr Raz Muhammad Bazai
Dr Manisha Kumari
Sandya Bai


Schizophrenia, Folic acid, Methylcobalamin, Risperidone, Clinical Symptoms, BDNF Serum, Adjuvant Therapy, Mental Health, Integrative Treatment, Cognitive Markers.


Schizophrenia, characterized by delusions, hallucinations, and cognitive impairments, poses significant challenges for individuals and society. This study investigates the effects of adjuvant therapy with folic acid and methylcobalamin on clinical symptoms and brain-derived neurotrophic factor (BDNF) levels in schizophrenia patients receiving risperidone. A total of 46 subjects participated in 8-week experimental analysis, with the treatment group receiving adjuvant therapy alongside risperidone at Department of Psychiatry, Jinnah Post Graduate Medical Centre Karachi. Positive and significant improvements in clinical symptoms (63.33%) and BDNF levels were observed in the treatment group compared to the control group. The study contributes valuable insights into the potential benefits of adjuvant therapy for schizophrenia treatment.

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