ROLE OF INTERVENTIONAL RADIOLOGY IN MANAGEMENT OF HEPATO-CELLULAR CARCINOMA (HCC)
Main Article Content
Keywords
HCC, Interventional radiology, HCC treatments, Radioembolization, Radiofrequency ablation.
Abstract
The most typical primary liver tumour, hepatocellular carcinoma, is becoming more prevalent. The two-gold standard curative treatment options are transplantation and surgical resection, but fewer than 20% of patients qualify as surgical candidates due to severe liver disease and/or co-morbidities. For the treatment of HCC that is inoperable, numerous interventional radiological techniques have been developed and thoroughly researched. The treatment of HCC currently heavily relies on interventional radiology. These methods have considerably aided in halting disease development in liver transplant candidates and extending survival in non-candidates. These medicines stand out for their low toxicity profiles, potent tumour response, and preservation of healthy hepatic parenchyma.
References
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3. Hartke, J., Johnson, M., & Ghabril, M. (2017). The diagnosis and treatment of hepatocellular carcinoma. Semin Diagn Pathol, 34, 153-159. [PubMed] [Google Scholar]
4. Dimitroulis, D., Damaskos, C., Valsami, S., Davakis, S., Garmpis, N., Spartalis, E., ... & Kouraklis, G. (2017). From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world. World journal of gastroenterology, 23(29), 5282-5294. [PMC free article] [PubMed] [Google Scholar]
5. Akinyemiju, T., Abera, S., Ahmed, M., Alam, N., Alemayohu, M. A., Allen, C., ... & Global Burden of Disease Liver Cancer Collaboration. (2017). The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: results from the global burden of disease study 2015. JAMA oncology, 3(12), 1683-1691. [PMC free article] [PubMed] [Google Scholar]
6. Kondo, F. (2009). Histological features of early hepatocellular carcinomas and their developmental process: for daily practical clinical application: hepatocellular carcinoma. Hepatol Int, 3, 283–93. doi: 10.1007/s12072-008-9107-9. [PMCfree article] [PubMed] [CrossRef] [Google Scholar]
7. Bruix, J., & Sherman, M. (2011). On behalf of the American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update. Hepatology, 53, 1020–2. [PMC free article] [PubMed] [Google Scholar]
8. Colecchia, A., Scaioli, E., Montrone, L., Vestito, A., Di Biase, A. R., Pieri, M., ... & Festi, D. (2011). Pre-operative liver biopsy in cirrhotic patients with early hepatocellular carcinoma represents a safe and accurate diagnostic tool for tumour grading assessment. Journal of hepatology, 54(2), 300-305. doi: 10.1016/j.jhep.2010.06.037. [PubMed] [CrossRef] [Google Scholar]
9. Pathi, R., & Burnes, J. (2013). Sydney, Australia: Inside Radiology, Royal Australian and New Zealand College of Radiologists. Image Guided Liver Biopsy [Web article][Available at: http://www.insideradiology.com.au/pages/view. php?T_id=85; cited January 17, 2013] [Google Scholar]
10. Soderstrom, C. A., McArdle, D. Q., Ducker, T. B., & Militello, P. R. (1983). The diagnosis of intra- abdominal injury in patients with cervical cord trauma. J Trauma,23, 1061–5. doi: 10.10 97/00005373-198312000-00008. [PubMed] [CrossRef] [Google Scholar]
11. Wang, P., Meng, Z. Q., Chen, Z., Lin, J. H., Ping, B., Wang, L. F., ... & Liu, L. M. (2008). Diagnostic value and complications of fine needle aspiration for primary liver cancer and its influence on the treatment outcome—a study based on 3011 patients in China. European Journal of Surgical Oncology (EJSO), 34(5), 541-546.doi: 10.1016/j.ejso.2007.07.013. [Pub Med] [CrossRef] [Google Scholar]
12. Edoute, Y., Tibon–Fisher, O., Ben-Haim, S. A., & Malberger, E. (1991). Imaging-guided and nonimaging-guided fine needle aspiration of liver lesions: experience with 406 patients. J Surg Oncol, 48, 246–51. doi: 10.1002/jso.2930480407. [PubMed] [CrossRef] [Google Scholar]
13. Jain, D. (2002). Diagnosis of hepatocellular carcinoma: fine needle aspiration cytology or needle core biopsy. J Clin Gastroenterol, 35(suppl 2), S101–8. doi: 10.1097/00004836-200211002- 00006. [PubMed] [CrossRef] [Google Scholar]
14. International Consensus Group for Hepatocellular Neoplasia. (2009). Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia. Hepatology, 49(2), 658-664. doi: 10.1002/hep.22709. [PubMed] [CrossRef] [Google Scholar]
15. McGahan, J. P., Bishop, J., Webb, J., Howell, L., Torok, N., Lamba, R., & Corwin, M. T. (2013). Role of FNA and core biopsy of primary and metastatic liver disease. International journal of hepatology, 2013, 174103. doi: 10.1155/2013/174103. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
16. França, A. V. C., Valério, H. M. G., Trevisan, M., Escanhoela, C., Sevá-Pereira, T., Zucoloto, S., & Soares, E. C. (2003). Fine needle aspiration biopsy for improving the diagnostic accuracy of cut needle biopsy of focal liver lesions. Acta cytologica, 47(3), 332-336. doi: 10.1159 /000326529. [PubMed] [CrossRef] [Google Scholar]
17. Al Knawy, B., & Shiffman, M. (2007). Percutaneous liver biopsy in clinical practice. Liver Int, 27, 1166–73. doi: 10.1111/j.1478- 3231.2007.01592.x. [PubMed] [CrossRef] [Google Scholar]
18. Procopet, B., Bureau, C., Métivier, S., Selves, J., Robic, M. A., Christol, C., ... & Péron, J. M. (2012). Tolerance of liver biopsy in a tertiary care center: comparison of the percutaneous and the transvenous route in 143 prospectively followed patients. European journal of gastroenterology & hepatology, 24(10), 1209-1213. doi: 10.1097/MEG.0b013e328355e2ba. [Pub Med] [CrossRef] [Google Scholar]
19. Stigliano, R., Marelli, L., Yu, D., Davies, N., Patch, D., & Burroughs, A. K. (2007). Seeding following percutaneous diagnostic and therapeutic approaches for hepatocellular carcinoma. What is the risk and the outcome? Seeding risk for percutaneous approach of hcc. Cancer Treat Rev, 33,437–47.doi: 10.1016/j.ctrv.2007.04.001. [PubMed] [CrossRef] [Google Scholar]
20. Takamori, R., Wong, L. L., Dang, C., & Wong, L. (2000). Needle-tract implantation from hepatocellular cancer: is needle biopsy of the liver always necessary? Liver Transpl, 6, 67–72. [PubMed] [Google Scholar]
21. Gadahadh, R., Valenti, D., Aljiffry, M., Kakiashvili, E., Chaudhury, P., Hassanain, M., & Metrakos, P. (2011). Surgery and interventional radiology collaborate on combination therapy in hepatocellular carcinoma. US Gastroenterol Hepatol Rev, 7, 44-49. [Google Scholar]
22. Gervais, D. A., Goldberg, S. N., Brown, D. B., Soulen, M. C., Millward, S. F., & Rajan, D. K. (2009). Society of Interventional Radiology position statement on percutaneous radiofrequency ablation for the treatment of liver tumors. J Vasc Interv Radiol, 20(suppl), S342–7. doi: 10.101 6/j.jvir.2009.04.029. [PubMed] [CrossRef] [Google Scholar]
23. Pompili, M., Mirante, V. G., Rondinara, G., Fassati, L. R., Piscaglia, F., Agnes, S., ... & Rapaccini, G. L. (2005). Percutaneous ablation procedures in cirrhotic patients with hepatocellular carcinoma submitted to liver transplantation: assessment of efficacy at explant analysis and of safety for tumor recurrence. Liver transplantation, 11(9), 1117-1126. doi: 10.1002/lt.20469. [PubMed] [CrossRef] [Google Scholar]
24. Gervais, D. A., Goldberg, S. N., Brown, D. B., Soulen, M. C., Millward, S. F., & Rajan, D. K. (2009). On behalf of the Interventional Oncology Task Force and Standards Division, Society of Interventional Radiology Society of Interventional Radiology position statement on percutaneous radiofrequency ablation for the treatment of liver tumors. J Vasc Interv Radiol, 20, 3–8. doi: 10.1016/j.jvir.2008.09.007. [PubMed] [CrossRef] [Google Scholar]
25. Koffron, A. J., Auffenberg, G., Kung, R., & Abecassis, M. (2007). Evaluation of 300 minimally invasive liver resections at a single institution: less is more. Ann Surg, 246, 385–92. doi:10.1097/SLA.0b013e318146996c. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
26. Orlando, A., Leandro, G., Olivo, M., Andriulli, A., & Cottone, M. (2009). Radiofrequency thermal ablation vs. percutaneous ethanol injection for small hepatocellular carcinoma in cirrhosis: meta- analysis of randomized controlled trials. Am J Gastroenterol, 104,514–24. doi: 10.1038/ajg.2008.80. [PubMed][CrossRef] [Google Scholar]
27. Curley, S. A., Izzo, F., Ellis, L. M., Nicolas Vauthey, J., & Vallone, P. (2000). Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann Surg, 232, 381–91. doi: 10.1097/00000658-200009000- 00010. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
28. Abdalla, E. K., Barnett, C. C., Doherty, D., Curley, S. A., & Vauthey, J. N. (2002). Extended hepatectomy in patients with hepatobiliary malignancies with and without preoperative portal vein embolization. Arch Surg, 137, 675–80. doi: 10.1001/archsurg.137.6.675. [PubMed] [CrossRef] [Google Scholar]
29. Tashiro, S., Miyake, H., & Yoshioka, K. (2011). The role of portal vein embolization prior to hepatic resection for primary and secondary hepatic malignancies. Eur J Clin Med Oncol, 3, 1-7. [Google Scholar]
30. Siriwardana, R. C., Lo, C. M., Chan, S. C., & Fan, S. T. (2012). Role of portal vein embolization in hepatocellular carcinoma management and its effect on recurrence: a case–control study. World J Surg, 36, 1640–6. doi: 10.1007/s00268-012-1522-3. [PMC freearticle] [PubMed] [CrossRef] [Google Scholar]
31. Simoneau, E., Aljiffry, M., Salman, A., Abualhassan, N., Cabrera, T., Valenti, D., ... & Metrakos, P. (2012). Portal vein embolization stimulates tumour growth in patients with colorectal cancer liver metastases. HPB(Oxford), 14(7), 461-468. doi: 10.1111/j.1477-2574.20 12.00476.x. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
32. Forner, A., & Trinchet, J. C. (2009). Transarterial therapies in hcc: does embolization increase survival? J Hepatol, 51,981–3. doi: 10.1016/j.jhep.2009.09.009. [PubMed] [CrossRef] [Google Scholar]
33. Nicolini, A., Fasani, P., Manini, M. A., Martinetti, L., Forzenigo, L. V., Iavarone, M., & Sangiovanni, A. (2009). Transarterial embolization with microspheres in the treatment of monofocal HCC. Digestive and Liver Disease, 41(2), 143-149. doi: 10.1016/j.dld.2008.03.004. [PubMed] [CrossRef] [Google Scholar]
34. Gerunda, G. E., Neri, D., Merenda, R., Barbazza, F., Zangrandi, F., Meduri, F.,& Faccioli, A. M. (2000). Role of transarterial chemoembolization before liver resection for hepatocarcinoma. Liver Transplantation, 6(5), 619-626. doi: 10.1053/jlts.2000.8312. [PubMed] [CrossRef] [Google Scholar]
35. de Lope, C. R., Tremosini, S., Forner, A., Reig, M., & Bruix, J. (2012). Management of hcc. J Hepatol, 56(suppl.1), S75–87. doi: 10.1016/S0168- 8278(12)60009-9. [PubMed] [CrossRef] [Google Scholar]
36. Barone, M., Ettorre, G. C., Ladisa, R., Schiavariello, M., Santoro, C., Francioso, G., & Francavilla, A. (2003). Transcatheter arterial chemoembolization (TACE) in treatment of hepatocellular carcinoma. Hepato- gastroenterology, 50(49), 183-187. [PubMed] [Google Scholar]
37. Llovet, J. M., Real, M. I., Montaña, X., Planas, R., Coll, S., Aponte, J., ... & Barcelona Clinic Liver Cancer Group. (2002). Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. The Lancet, 359(9319),1734-1739. doi: 10.1016/S0140-6736(02)08649-X. [PubMed] [Cross Ref] [Google Scholar]
38. Malagari, K., Alexopoulou, E., Chatzimichail, K., Hall, B., Koskinas, J., Ryan, S., & Kelekis, D. (2008). Transcatheter chemoembolization in the treatment of HCC in patients not eligible for curative treatments: midterm results of doxorubicin-loaded DC bead. Abdominal imaging, 33(5), 512-519. doi: 10.1007/s00261-007-9334-x. [PubMed] [CrossRef] [Google Scholar]
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Nov 25, 2022
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Mobarak Naji bin Mobarak Alyami, Mahdi Naji bin Mobarak Al yami, Mahdi Ali bin Mohammad Alsharyah, Mohammed Dhafer Abdullah Alghubari, Ahmad Saleh Alqahat, Saeedah Hamad bin Hassan Alshaiban, & Ali Ahmad Alsagoor. (2022). ROLE OF INTERVENTIONAL RADIOLOGY IN MANAGEMENT OF HEPATO-CELLULAR CARCINOMA (HCC). Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 1697-1704. https://doi.org/10.53555/jptcp.v29i04.4856
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Author Biographies
Mobarak Naji bin Mobarak Alyami
Specialist, Radiological Technology, Maternity and Children’s Hospital, Saudi Arabia
Mahdi Naji bin Mobarak Al yami
Technician, Radiological Technology, Najran General Hospital, Saudi Arabia
Mahdi Ali bin Mohammad Alsharyah
Specialist, Radiological Technology, Najran New General Hospital, Saudi Arabia
Mohammed Dhafer Abdullah Alghubari
Specialist, Radiological Technology, Maternity and Children’s Hospital, Saudi Arabia
Ahmad Saleh Alqahat
Specialist, Radiological Technology, Maternity and Children’s Hospital, Saudi Arabia
Saeedah Hamad bin Hassan Alshaiban
Specialist, Nirsinh, Maternity and Children’s Hospital, Saudi Arabia
Ali Ahmad Alsagoor
Specialist, Radiological Technology, Najran New General Hospital, Saudi Arabia
How to Cite
Mobarak Naji bin Mobarak Alyami, Mahdi Naji bin Mobarak Al yami, Mahdi Ali bin Mohammad Alsharyah, Mohammed Dhafer Abdullah Alghubari, Ahmad Saleh Alqahat, Saeedah Hamad bin Hassan Alshaiban, & Ali Ahmad Alsagoor. (2022). ROLE OF INTERVENTIONAL RADIOLOGY IN MANAGEMENT OF HEPATO-CELLULAR CARCINOMA (HCC). Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 1697-1704. https://doi.org/10.53555/jptcp.v29i04.4856
