BIOCHEMICAL EVALUATION OFVACCINIUM MACROCARPON AND EMBLICA OFFICINALIS IN ALLEVIATING ULCERATIVE COLITIS IN MICE

Main Article Content

Pari Gul
Malik Ihsan Ullah Khan
Sadaf Ajmal
Shaista Anjum
Ayeesha Masood
Kulsoom Baloch

Keywords

V. macrocarpon, E. officinalis, Ulcerative colitis, Mice, Biochemical evaluation, Ulcerative Colitis, Therapeutic potential.

Abstract

The chronic inflammatory disease ulcerative colitis, which affects the colon and rectum, causes much
healthcare morbidity and burden. Because conventional medicine couldn't relieve or prevent
symptoms, complementary and alternative therapies were sought. This mouse model study examines
the biochemical effects of cranberry and amla extracts on ulcerative colitis symptom. Evidence
supports the claim that these compounds reduce oxidative stress markers, retain mucosal membrane
integrity in colitic mice, and lower pro-inflammatory cytokines (e.g., TNF-α and IL-6). Because of
their complex action mechanisms, they target many pathogenic pathways involved in UC
pathophysiology. This makes them effective. UC patients can receive individualized and holistic
treatment by incorporating evidence-based research on natural products and herbal remedies. Due to
natural and herbal ingredients, this is possible. Patients would have access to additional therapeutic
alternatives as a result of this circumstance, which would ultimately result in an increase in the quality
of life that they experience.

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