EFFICACY OF WIDEFIELD RETINAL IMAGING VERSUS INDIRECT OPHTHALMOSCOPY IN DETECTING RETINOPATHY OF PREMATURITY: A COMPARATIVE OBSERVATIONAL STUDY.

Main Article Content

Balakrushna Samantaray
Subhabrata Parida
Kumari Krishna Patro
Aparajita Banerjee
Shubham Sethy
Subhodeep Thakur

Keywords

Retinopathy of prematurity, binocular indirect ophthalmoscopy, widefield digital retinal photography, RETCAM

Abstract

The primary goal of this study is to evaluate the efficacy of RetCam and binocular indirect ophthalmoscopy (BIO) as part of the screening process for retinopathy of prematurity (ROP), the leading cause of preventable blindness in newborns globally. This research will be conducted to determine whether or not these two methods are effective. The retinopathy of prematurity, often known as ROP, is a vasoproliferative condition that, if not identified and treated promptly, can lead to blindness that cannot be reversed. A single-center, double-blind, prospective diagnostic accuracy design was utilized for this research investigation, which was carried out in a tertiary neonatal critical care facility in Cuttack. 400 tests were carried out by two qualified ophthalmologists who used RetCam and BIO to examine 202 preterm infants. Within twenty-four hours after the BIO observation, the RetCam was conducted. An examiner, who wore a disguise, examined the images to determine the presence or absence of plus disease, the stage and zone of the illness, whether the patient had ROP, and whether the disease was treatable. The results showed that RetCam was beneficial for screening ROP owing to its practicality and efficacy in identifying the illness in our context, even though BIO was better at staging and grading the condition. RetCam might be considered an adjunct to BIO for routine ROP screening.

Abstract 105 | pdf Downloads 68

References

1. Desmond MG, Bremond-Gignac D, Torchin H, Vacherot B, Jarreau PH, Daruich A. Retinopathy of prematurity detection: a retrospective quality improvement project before-after implementation of retinal digital imaging for screening. European Journal of Pediatrics. 2023 Apr 19:1-7.
2. Zhang L, Buonfiglio F, Fieß A, Pfeiffer N, Gericke A. Retinopathy of Prematurity—Targeting Hypoxic and Redox Signaling Pathways. Antioxidants. 2024 Jan 25;13(2):148.
3. Ndyabawe I, Namiiro F, Muhumuza AT, Nakibuka J, Otiti J, Ampaire A, Kasadhakawo M, Msonge F, Mohamed S, Nyanzi M, Tumukunde VS. Prevalence and pattern of retinopathy of prematurity at two national referral hospitals in Uganda: a cross-sectional study. BMC ophthalmology. 2023 Nov 22;23(1):478.
4. Sekeroglu MA, Hekimoglu E, Sekeroglu HT, Arslan U. Alternative methods for the screening of retinopathy of prematurity: binocular indirect ophthalmoscopy vs widefield digital retinal imaging. Eye. 2013 Sep;27(9):1053-7.
5. Dai S, Chow K, Vincent A. Efficacy of widefield digital retinal imaging for retinopathy of prematurity screening. Clinical & experimental ophthalmology. 2011 Jan;39(1):23-9.
6. Gariano RF, Ge JN, Stoessel KM. Pathogenesis and Surgical Management of Common Geriatric Ophthalmic Disorders. InPrinciples and Practice of Geriatric Surgery 2013 Jun 29 (pp. 348-367). New York, NY: Springer, New York.
7. Skorin L, Lighthizer NR, Castillo R, McGee S, Stonecipher K. The Ophthalmic Office Procedures Handbook. Lippincott Williams & Wilkins; 2023 Nov 29.
8. de Kartzow AV, Acevedo PJ, Saidman G, Schbib V, Zuluaga C, Monteoliva G, Carrascal M, Salvatelli A, Patiño S, Marmol J, Ferres JL. Smartphone Telemedicine Networks for Retinopathy of Prematurity (ROP) in Latin America: SP-ROP (Panamerican Society of ROP). InDigital Eye Care and Teleophthalmology: A Practical Guide to Applications 2023 Jun 20 (pp. 253-295). Cham: Springer International Publishing.
9. Brown S. The accuracy of the RetCam as a widefield digital retinal imaging device relative to binocular indirect ophthalmoscopy for diagnosing retinopathy of prematurity: A systematic review of diagnostic test accuracy. Australian Orthoptic Journal. 2021 Dec 1;53:30-9.
10. Athikarisamy SE, Lam GC, Ross S, Rao SC, Chiffings D, Simmer K, Bulsara MK, Patole S. Comparison of widefield imaging by nurses with indirect ophthalmoscopy by ophthalmologists for retinopathy of prematurity: a diagnostic accuracy study. BMJ open. 2020;10(8).
11. Roth DB, Morales D, Feuer WJ, Hess D, Johnson RA, Flynn JT. Screening for retinopathy of prematurity employing the RetCam 120: sensitivity and specificity. Archives of Ophthalmology. 2001 Feb 1;119(2):268-72.
12. Takase H, Okada AA, Goto H, Mizuki N, Namba K, Ohguro N, Sonoda KH, Tomita M, Keino H, Kezuka T, Kubono R. Development and validation of new diagnostic criteria for acute retinal necrosis. Japanese journal of ophthalmology. 2015 Jan;59:14-20.
13. Lorenz B, Spasovska K, Elflein H, Schneider N. Widefield digital imaging-based telemedicine for screening for acute retinopathy of prematurity (ROP). Six-year results of a multicentre field study. Graefe's Archive for Clinical and Experimental Ophthalmology. 2009 Sep;247:1251-62.
14. Martínez-Castellanos MA, Schwartz S, Hernández-Rojas ML, Kon-Jara VA, García-Aguirre G, Guerrero-Naranjo JL, Chan RP, Quiroz–Mercado H. Long-term effect of antiangiogenic therapy for retinopathy of prematurity up to 5 years of follow-up. Retina. 2013 Feb 1;33(2):329-38.
15. Schwartz R, Khalid H, Sivaprasad S, Nicholson L, Anikina E, Sullivan P, Patel PJ, Balaskas K, Keane PA. Objective evaluation of proliferative diabetic retinopathy using OCT. Ophthalmology Retina. 2020 Feb 1;4(2):164-74.
16. Sinclair SH, Schwartz SS. Diabetic retinopathy–an underdiagnosed and undertreated inflammatory, neuro-vascular complication of diabetes. Frontiers in Endocrinology. 2019 Dec 13;10:843.
17. Hanif AM, Jian Y, Young BK, Campbell JP. Implementation of optical coherence tomography in retinopathy of prematurity screening. Current Opinion in Ophthalmology. 2024 Jan 12:10-97.