ASSESSMENT OF MULTIDRUG RESISTANCE IN FALCON BACTERIAL ISOLATES: IMPLICATIONS FOR THERAPEUTIC APPROACHES

Main Article Content

Qurat-ul-Ain
Kainat Gul
Khizar Rahman
Nishat Zafar
Zain Ul Abedien
Abdul Malik

Keywords

resistance, infections, multidrug, antimicrobials

Abstract

The emergence of bacterial resistance to antimicrobials employed in veterinary medicine poses a significant threat to the efficacy of human antibiotic therapy. This study primarily investigates the efficacy of antibiotics against bacterial strains isolated from Falcons. A retrospective analysis was conducted using samples collected from various swab sites of falcons admitted to Souq Waqif Falcon hospital during the falconry season. Bacterial strains were identified using biochemical assays and the Vitek-2 system, with susceptibility to a range of antibiotics assessed. Data analysis followed the guidelines outlined by the Clinical and Laboratory Standards Institute. A total of 564 bacterial strains were isolated from falcons, with Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli being the most prevalent. Resistance to at least one antibiotic was observed in 93.6% of the isolates, with 55.4% exhibiting multidrug resistance (MDR). Notably, oxacillin, erythromycin, and amoxicillin showed the highest rates of resistance, while clindamycin, ampicillin, and amikacin demonstrated the most favorable efficacy. These findings suggest that clindamycin, ampicillin, and amikacin could be viable treatment options for bacterial infections in falcons. Nonetheless, further research is warranted to validate these results and establish comprehensive treatment protocols for bacterial infections in falcons.


 


Keywords: resistance, infections, multidrug, antimicrobials


The emergence of bacterial resistance to antimicrobials employed in veterinary medicine poses a significant threat to the efficacy of human antibiotic therapy. This study primarily investigates the efficacy of antibiotics against bacterial strains isolated from Falcons. A retrospective analysis was conducted using samples collected from various swab sites of falcons admitted to Souq Waqif Falcon hospital during the falconry season. Bacterial strains were identified using biochemical assays and the Vitek-2 system, with susceptibility to a range of antibiotics assessed. Data analysis followed the guidelines outlined by the Clinical and Laboratory Standards Institute. A total of 564 bacterial strains were isolated from falcons, with Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli being the most prevalent. Resistance to at least one antibiotic was observed in 93.6% of the isolates, with 55.4% exhibiting multidrug resistance (MDR). Notably, oxacillin, erythromycin, and amoxicillin showed the highest rates of resistance, while clindamycin, ampicillin, and amikacin demonstrated the most favorable efficacy. These findings suggest that clindamycin, ampicillin, and amikacin could be viable treatment options for bacterial infections in falcons. Nonetheless, further research is warranted to validate these results and establish comprehensive treatment protocols for bacterial infections in falcons.

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References

1. Ahmad, A. R., Ridgeway, S., Shibl, A. A., Idaghdour, Y., & Jha, A. R. (2024). Falcon gut microbiota is shaped by diet and enriched in Salmonella. Plos one, 19(1), e0293895.
2. AL-Enawey, A. W., Saadedin, S. M., & Al-Khaldi, S. A. M. (2020). Isolation, Identification And Antimicrobial Susceptibility Of Staphylococcus aureus And Acinetobacter Baumannii Isolated From Babylon Hospitals.
3. Arné, P., Risco-Castillo, V., Jouvion, G., Le Barzic, C., & Guillot, J. (2021). Aspergillosis in wild birds. Journal of Fungi, 7(3), 241.
4. Berhe, G., Wasihun, A. G., Kassaye, E., & Gebreselasie, K. (2020). Milk-borne bacterial health hazards in milk produced for commercial purpose in Tigray, northern Ethiopia. BMC Public Health, 20, 1-8.
5. Cao, J., Hu, Y., Liu, F., Wang, Y., Bi, Y., Lv, N., ... & Gao, G. F. (2020). Metagenomic analysis reveals the microbiome and resistome in migratory birds. Microbiome, 8, 1-18.
6. Christensen, H., Bachmeier, J., & Bisgaard, M. (2021). New strategies to prevent and control avian pathogenic Escherichia coli (APEC). Avian Pathology, 50(5), 370-381.
7. De Luca, C., Niero, G., Cattarossi, D., Bedin, M., & Piccirillo, A. (2018). Pet and captive birds as potential reservoirs of zoonotic Bacteria. Journal of Exotic Pet Medicine, 27(1), 17-20.
8. De Oliveira, D. M., Forde, B. M., Kidd, T. J., Harris, P. N., Schembri, M. A., Beatson, S. A., ... & Walker, M. J. (2020). Antimicrobial resistance in ESKAPE pathogens. Clinical microbiology reviews, 33(3), 10-1128.
9. Grond, K., Sandercock, B. K., Jumpponen, A., & Zeglin, L. H. (2018). The avian gut microbiota: community, physiology and function in wild birds. Journal of Avian Biology, 49(11), e01788.
10. Gu, Z., Pan, S., Lin, Z., Hu, L., Dai, X., Chang, J., ... & Zhan, X. (2021). Climate-driven flyway changes and memory-based long-distance migration. Nature, 591(7849), 259-264.
11. Konicek, C., Vodrážka, P., Barták, P., Knotek, Z., Hess, C., Račka, K., ... & Troxler, S. (2016). Detection of zoonotic pathogens in wild birds in the cross-border region Austria–Czech Republic. Journal of wildlife diseases, 52(4), 850-861.
12. Lawhon, S. D., Burbick, C. R., Munson, E., Zapp, A., Thelen, E., & Villaflor, M. (2023). Update on novel taxa and revised taxonomic status of bacteria isolated from nondomestic animals described in 2018 to 2021. Journal of Clinical Microbiology, 61(2), e01425-22.
13. Mahadevia, P., & Brandwein-Gensler, M. (2019). Infectious diseases of the head and neck. In Surgical pathology of the head and neck (pp. 1695-1802). CRC Press.
14. Marcelino, V. R., Wille, M., Hurt, A. C., González-Acuña, D., Klaassen, M., Schlub, T. E., ... & Holmes, E. C. (2019). Meta-transcriptomics reveals a diverse antibiotic resistance gene pool in avian microbiomes. BMC biology, 17(1), 1-11.
15. Mohan, J., Kolluri, G., Srivastava, V., Tyagi, J. S., & Tiwari, A. K. (2023). Bacterial contamination of poultry semen, its dilution and storage. World's Poultry Science Journal, 79(3), 593-617.
16. Nemeth, N. M. (2024). Raptors. Pathology of Pet and Aviary Birds, 563-599.
17. Nourani, L., Aliabadian, M., Mirshamsi, O., & Dinparast Djadid, N. (2022). Prevalence of co-infection and genetic diversity of avian haemosporidian parasites in two rehabilitation facilities in Iran: implications for the conservation of captive raptors. BMC Ecology and Evolution, 22(1), 114.
18. Nowaczek, A., Dec, M., Stępień-Pyśniak, D., Urban-Chmiel, R., Marek, A., & Różański, P. (2021). Antibiotic resistance and virulence profiles of Escherichia coli strains isolated from wild birds in Poland. Pathogens, 10(8), 1059.
19. Nowaczek, A., Dec, M., Stępień-Pyśniak, D., Urban-Chmiel, R., Marek, A., & Różański, P. (2021). Antibiotic resistance and virulence profiles of Escherichia coli strains isolated from wild birds in Poland. Pathogens, 10(8), 1059.
20. Pimenov, N. V., Konstantinov, A. V., & Pavlova, A. V. (2020, August). Bacteriological profile in falcon-like birds under aviary captive conditions. In IOP Conference Series: Earth and Environmental Science (Vol. 548, No. 7, p. 072012). IOP Publishing.
21. Pimenov, N. V., Konstantinov, A. V., & Pavlova, A. V. (2020, August). Bacteriological profile in falcon-like birds under aviary captive conditions. In IOP Conference Series: Earth and Environmental Science (Vol. 548, No. 7, p. 072012). IOP Publishing.
22. Pyzik, E., Dec, M., Stępień–Pyśniak, D., Marek, A., Piedra, J. L. V., Chałabis-Mazurek, A., ... & Urban-Chmiel, R. (2021). The presence of pathogens and heavy metals in urban peregrine falcons (Falco peregrinus). Veterinary World, 14(7), 1741.
23. Ramey, A. M., & Ahlstrom, C. A. (2020). Antibiotic resistant bacteria in wildlife: Perspectives on trends, acquisition and dissemination, data gaps, and future directions. Journal of Wildlife Diseases, 56(1), 1-15.
24. Saleh, A. E. (2021). Hydrocarbon Degrading Candidate Bacteria Isolated From Qatar Polluted Soil and Molecular Identification of Key Enzymes Coding Genes (Master's thesis).
25. Smith, O. M., Snyder, W. E., & Owen, J. P. (2020). Are we overestimating risk of enteric pathogen spillover from wild birds to humans?. Biological Reviews, 95(3), 652-679.
26. Sun, F., Chen, J., Liu, K., Tang, M., & Yang, Y. (2022). The avian gut microbiota: Diversity, influencing factors, and future directions. Frontiers in Microbiology, 13, 934272.
27. Tjoa, E., Moehario, L. H., Rukmana, A., & Rohsiswatmo, R. (2013). Acinetobacter baumannii: role in blood stream infection in neonatal unit, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. International Journal of Microbiology, 2013.
28. Venkadesan, D., Sumathi, V., & Venkadesan, C. D. (2015). Screening of lactic acid bacteria for their antibacterial activity against milk borne pathogens. International Journal of Applied Research, 1(11), 970-973.
29. Wilcox, J. J., Boissinot, S., & Idaghdour, Y. (2019). Falcon genomics in the context of conservation, speciation, and human culture. Ecology and Evolution, 9(24), 14523-14537.
30. Yetkin, F., Yakupogullari, Y., Kuzucu, C., Ersoy, Y., Otlu, B., Colak, C., & Parmaksiz, N. (2018). Pathogens of intensive care unit-acquired infections and their antimicrobial resistance: a 9-year analysis of data from a university hospital. Jundishapur Journal of Microbiology, 11(10).