FREQUENCY OF CLINICOPATHOLOGICAL SPECTRUM OF IMMUNOBULLOUS DISORDERS

Main Article Content

Faryal Shareef
Erum Ashraf
Misbah Zakir Abowath
Muneebah Siddiqui
Sarosh Shareef
Madiha Shareef

Keywords

Autoimmuno bullous disorders, Bullous pemphigoid, Pemphigus

Abstract

Introduction: Autoimmune vesiculobullous disorders are rare diseases that are characterized by blisters over skin and oral erosions. An accurate diagnosis is achieved by clinical examination, pathological correlation, and immunofluorescence.


Objective: To determine the frequency of clinicopathological spectrum of immunobullous disorders presenting to a tertiary care setup.


Methodology: This cross-sectional study conducted at the Department of Dermatology, Civil Hospital, Karachi, spanned six months from February 28, 2018, to August 28, 2018. The subjects comprised all patients meeting the inclusion criteria who visited the department during this period. Following ethical approval and obtaining informed written consent, the patients underwent a comprehensive evaluation, including a brief history and thorough cutaneous and systemic examinations. The study aimed to delineate the clinicopathological spectrum of immunobullous disorders.


Results: A total of 55 patients with immunobullous disease were included. 19 patients (34.5%) were males & 36 patients (65.5%) were females with the mean age was 44.04+13.620 years. Clinicopathological variants of immunobullous disorders was Subepidermal in 26 (47.3%) & Intraepidermal in 29 (52.7%).


Conclusion: Thorough clinical examination, aided by histopathology was helpful in arriving at a diagnosis of these vesiculobullous disorders in resource-poor center like ours where the gold standard immunofluorescence studies are not available.

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