Frequencies of different vascular etiologies and clinical presentations in post-partum women with suspected stroke

Main Article Content

Azrung Fayaz, Habiba Inayat, Muzammil Khalid, Safi Ullah Khan, Mamoon Gul, Khalid Hussain

Keywords

Arterial Thrombosis, Cerebral Venous Sinus Thrombosis, Postpartum, Stroke

Abstract

To assess the frequencies of different vascular etiologies and clinical presentations in post-partum women with suspected stroke.


Materials and Methods:  In this cross sectional study, we enrolled a total of 118 female in post-partum period of 30 days after delivery having clinical diagnosis of suspected stroke. Following an evaluation of each patient, the clinical presentation and frequency of various vascular aetiologies were recorded. The study duration was 6 month from February 2023 to July, 2023 and was conducted at Department of Medicine, Hayatabad Medical Complex, Peshawar.


Results: The mean age of all patients were 33.83±7.4 years. 10% of patients were suffering from Arterial thrombosis, 20% patients from cerebral venous sinus thrombosis and 70% patients were suffering from hemorrhagic stroke. Clinical presentation of all the enrolled patients were shown as 53.8%, 44.5%, 22.9% and 16.1% patients have symptoms of   Headache, Seizures, Altered Consciousness and Weakness respectively. We have found 26.3%, 20.3%, 28.6% and 15.1% patients were suffering from hypertension, DM, proteinuria and anemia respectively. We have stratified arterial thrombosis, cerebral vein thrombosis, and hemorrhagic stroke according to many risk variables, including place of residence, hypertension, diabetes mellitus, proteinuria, and anaemia. All other factors have an insignificant P-value, with the exception of age group.


Conclusion: In postpartum women suspected of having had a stroke, headaches were the most prevalent clinical manifestation, while hemorrhagic strokes were the most common vascular etiology

Abstract 211 | PDF Downloads 131

References

1. Swartz RH, Cayley ML, Foley N, Ladhani NNN, Leffert L, Bushnell C, et al. The incidence of pregnancy-related stroke: a systematic review and meta-analysis. International Journal of Stroke. 2017;12(7):687-97.
2. Miller EC, Gallo M, Kulick ER, Friedman AM, Elkind MS, Boehme AK. Infections and risk of peripartum stroke during delivery admissions. Stroke. 2018;49(5):1129-34.
3. Zambrano MD, Miller EC. Maternal stroke: an update. Current atherosclerosis reports. 2019;21:1-12.
4. Idiculla PS, Gurala D, Palanisamy M, Vijayakumar R, Dhandapani S, Nagarajan E. Cerebral venous thrombosis: a comprehensive review. European neurology. 2020;83(4):369-79.
5. Kılıç T, Akakın A. Anatomy of cerebral veins and sinuses. Handbook on cerebral venous thrombosis. 2008;23:4-15.
6. Luo Y, Tian X, Wang X. Diagnosis and treatment of cerebral venous thrombosis: a review. Frontiers in aging neuroscience. 2018;10:2.
7. Stam J. Thrombosis of the cerebral veins and sinuses. New England Journal of Medicine. 2005;352(17):1791-8.
8. Camargo EC, Singhal AB. Stroke in pregnancy: a multidisciplinary approach. Obstetrics and Gynecology Clinics. 2021;48(1):75-96.
9. Yoshida K, Takahashi JC, Takenobu Y, Suzuki N, Ogawa A, Miyamoto S. Strokes associated with pregnancy and puerperium: a nationwide study by the Japan Stroke Society. Stroke. 2017;48(2):276-82.
10. ud Din F, Akram M, Abidin SZU, Jilani G, Saeed MW. Frequencies of different vascular etiologies and clinical presentations in post-partum women with suspected stroke. The Professional Medical Journal. 2023;30(08):1015-20.
11. Saposnik G, Barinagarrementeria F, Brown Jr RD, Bushnell CD, Cucchiara B, Cushman M, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(4):1158-92.
12. Wright J, Hutchison A. Cardiovascular disease in patients with chronic kidney disease. Vascular health and risk management. 2009:713-22.
13. Yuan J, Zou X-R, Han S-P, Cheng H, Wang L, Wang J-W, et al. Prevalence and risk factors for cardiovascular disease among chronic kidney disease patients: results from the Chinese cohort study of chronic kidney disease (C-STRIDE). BMC nephrology. 2017;18:1-12.
14. Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation. 2003;108(17):2154-69.
15. Crasto W, Patel V, Davies MJ, Khunti K. Prevention of microvascular complications of diabetes. Endocrinology and Metabolism Clinics. 2021;50(3):431-55.
16. Jarvie JL, Metz TD, Davis MB, Ehrig JC, Kao DP. Short-term risk of cardiovascular readmission following a hypertensive disorder of pregnancy. Heart. 2018;104(14):1187-94.
17. Grear KE, Bushnell CD. Stroke and pregnancy: clinical presentation, evaluation, treatment and epidemiology. Clinical obstetrics and gynecology. 2013;56(2):350.
18. Tate J, Bushnell C. Pregnancy and stroke risk in women. Women’s health. 2011;7(3):363-74.
19. Lelubre C, Bouzat P, Crippa IA, Taccone FS. Anemia management after acute brain injury. Critical care. 2016;20(1):1-11.