Assessment of the autophagy biomarker level in Diabetic Kidney Disease Patients
Main Article Content
Keywords
Diabetic kidney disease, Beclin- 1, Autophagy biomarker
Abstract
The most frequent long-term consequence of diabetes mellitus is diabetic nephropathy (DN), which is also one of the main causes of end-stage renal disease (ESRD). Recent research indicates that impaired autophagy has a role in the development and course of diabetic kidney disease. So, we aimed in this study to assess the autophagy biomarker Beclin-1 level in diabetic kidney disease patients
References
1. Mohamed MM, Eissa S, Mostafa M, et al. Diabetic Nephropathy Assessment: Microtubule-Associated Protein 1 Light-Chain 3B a New Promising Biomarker. Indian J Clin Biochem. 2019; 34(4):472-478. doi: 10.1007/s12291-018-0773-7.
2. Li-hua Liu, Qiao-yan Guo, Chao-yuan Li, et al. Novel Biomarkers for Early Diagnosis and Progression of Diabetic Nephropathy. ARC J Diabetes Endocrinol. 2015; 1(1): 19-23. doi: http://dx.doi.org/10.20431/2455-5983.0101003.
3. Yang D, Livingston MJ, Liu Z, et al. Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential. Cell Mol Life Sci. 2018; 75(4):669-688. doi: 10.1007/s00018-017-2639-1.
4. Sturmlechner I, Durik M, Sieben CJ, et al. Cellular senescence in renal ageing and disease. Nat Rev Nephrol. 2017; 13(2):77-89. doi: 10.1038/nrneph.2016.183.
5. Fang L, Zhou Y, Cao H, et al. Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. PLoS One. 2013; 8(4):e60546. doi: 10.1371/journal.pone.0060546.
6. Wu W, Zhang M, Liu Q, et al. Piwil 2 gene transfection changes the autophagy status in a rat model of diabetic nephropathy. Int J Clin Exp Pathol. 2015; 8(9):10734-42. PMID: 26617784; PMCID: PMC4637599.
7. Li L, Jick S, Breitenstein S, et al. Prevalence of Diabetes and Diabetic Nephropathy in a Large U.S. Commercially Insured Pediatric Population, 2002-2013. Diabetes Care. 2016; 39(2):278-84. doi: 10.2337/dc15-1710.
8. Jiang G, Luk AO, Tam CHT, et al. Clinical Predictors and Long-term Impact of Acute Kidney Injury on Progression of Diabetic Kidney Disease in Chinese Patients With Type 2 Diabetes. Diabetes. 2022; 71(3):520-529. doi: 10.2337/db21-0694.
9. Go AS, Yang J, Tan TC, et al. Contemporary rates and predictors of fast progression of chronic kidney disease in adults with and without diabetes mellitus. BMC Nephrol. 2018; 19(1):146. doi: 10.1186/s12882-018-0942-1.
10. Jiang G, Luk AOY, Tam CHT, et al. Progression of diabetic kidney disease and trajectory of kidney function decline in Chinese patients with Type 2 diabetes. Kidney Int. 2019; 95(1):178-187. doi: 10.1016/j.kint.2018.08.026.
11. Naguib M and Rashed LA. Serum level of the autophagy biomarker Beclin-1 in patients with diabetic kidney disease. Diabetes Res Clin Pract. 2018; 143:56-61. doi: 10.1016/j.diabres.2018.06.022.
12. Cheng Y, Shang J, Liu D, et al. Development and validation of a predictive model for the progression of diabetic kidney disease to kidney failure. Ren Fail. 2020; 42(1):550-559. doi: 10.1080/0886022X.2020.1772294.
13. Rodríguez-Segade S, Rodríguez J, García López JM, et al. Intrapersonal HbA(1c) variability and the risk of progression of nephropathy in patients with Type 2 diabetes. Diabet Med. 2012; 29(12):1562-6. doi: 10.1111/j.1464-5491.2012.03767.x.
14. Janmaat CJ, van Diepen M, Gasparini A, et al. Lower serum calcium is independently associated with CKD progression. Sci Rep. 2018; 8(1):5148. doi: 10.1038/s41598-018-23500-5.
15. Fernández ÁF, Sebti S, Wei Y, et al. Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice. Nature. 2018 Jun; 558(7708):136-140. doi: 10.1038/s41586-018-0162-7. Epub 2018 May 30. Erratum in: Nature. 2018; 561(7723):E30. PMID: 29849149.
16. Zhang Y, Tang LH, Lu J, et al. ABT-263 enhanced bacterial phagocytosis of macrophages in aged mouse through Beclin-1-dependent autophagy. BMC Geriatr. 2021; 21(1):225. doi: 10.1186/s12877-021-02173-2. PMID: 33794800.
17. Xu HD and Qin ZH. Beclin 1, Bcl-2 and Autophagy. Adv Exp Med Biol. 2019; 1206:109-126. doi: 10.1007/978-981-15-0602-4_5.
18. Okuyan HM, Dogan S, Bal T, et al. Beclin-1, an autophagy-related protein, is associated with the disease severity of COVID-19. Life Sci. 2021; 278:119596. doi: 10.1016/j.lfs.2021.119596.
19. Zalckvar E, Berissi H, Mizrachy L, et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep. 2009; 10(3):285-92. doi: 10.1038/embor.2008.246.
20. Chang NC, Nguyen M, Germain M, et al. Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. EMBO J. 2010; 29(3):606-18. doi: 10.1038/emboj.2009.369.
21. Vicencio JM, Ortiz C, Criollo A, et al. The inositol 1, 4, 5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ. 2009; 16(7):1006-17. doi: 10.1038/cdd.2009.34.
2. Li-hua Liu, Qiao-yan Guo, Chao-yuan Li, et al. Novel Biomarkers for Early Diagnosis and Progression of Diabetic Nephropathy. ARC J Diabetes Endocrinol. 2015; 1(1): 19-23. doi: http://dx.doi.org/10.20431/2455-5983.0101003.
3. Yang D, Livingston MJ, Liu Z, et al. Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential. Cell Mol Life Sci. 2018; 75(4):669-688. doi: 10.1007/s00018-017-2639-1.
4. Sturmlechner I, Durik M, Sieben CJ, et al. Cellular senescence in renal ageing and disease. Nat Rev Nephrol. 2017; 13(2):77-89. doi: 10.1038/nrneph.2016.183.
5. Fang L, Zhou Y, Cao H, et al. Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. PLoS One. 2013; 8(4):e60546. doi: 10.1371/journal.pone.0060546.
6. Wu W, Zhang M, Liu Q, et al. Piwil 2 gene transfection changes the autophagy status in a rat model of diabetic nephropathy. Int J Clin Exp Pathol. 2015; 8(9):10734-42. PMID: 26617784; PMCID: PMC4637599.
7. Li L, Jick S, Breitenstein S, et al. Prevalence of Diabetes and Diabetic Nephropathy in a Large U.S. Commercially Insured Pediatric Population, 2002-2013. Diabetes Care. 2016; 39(2):278-84. doi: 10.2337/dc15-1710.
8. Jiang G, Luk AO, Tam CHT, et al. Clinical Predictors and Long-term Impact of Acute Kidney Injury on Progression of Diabetic Kidney Disease in Chinese Patients With Type 2 Diabetes. Diabetes. 2022; 71(3):520-529. doi: 10.2337/db21-0694.
9. Go AS, Yang J, Tan TC, et al. Contemporary rates and predictors of fast progression of chronic kidney disease in adults with and without diabetes mellitus. BMC Nephrol. 2018; 19(1):146. doi: 10.1186/s12882-018-0942-1.
10. Jiang G, Luk AOY, Tam CHT, et al. Progression of diabetic kidney disease and trajectory of kidney function decline in Chinese patients with Type 2 diabetes. Kidney Int. 2019; 95(1):178-187. doi: 10.1016/j.kint.2018.08.026.
11. Naguib M and Rashed LA. Serum level of the autophagy biomarker Beclin-1 in patients with diabetic kidney disease. Diabetes Res Clin Pract. 2018; 143:56-61. doi: 10.1016/j.diabres.2018.06.022.
12. Cheng Y, Shang J, Liu D, et al. Development and validation of a predictive model for the progression of diabetic kidney disease to kidney failure. Ren Fail. 2020; 42(1):550-559. doi: 10.1080/0886022X.2020.1772294.
13. Rodríguez-Segade S, Rodríguez J, García López JM, et al. Intrapersonal HbA(1c) variability and the risk of progression of nephropathy in patients with Type 2 diabetes. Diabet Med. 2012; 29(12):1562-6. doi: 10.1111/j.1464-5491.2012.03767.x.
14. Janmaat CJ, van Diepen M, Gasparini A, et al. Lower serum calcium is independently associated with CKD progression. Sci Rep. 2018; 8(1):5148. doi: 10.1038/s41598-018-23500-5.
15. Fernández ÁF, Sebti S, Wei Y, et al. Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice. Nature. 2018 Jun; 558(7708):136-140. doi: 10.1038/s41586-018-0162-7. Epub 2018 May 30. Erratum in: Nature. 2018; 561(7723):E30. PMID: 29849149.
16. Zhang Y, Tang LH, Lu J, et al. ABT-263 enhanced bacterial phagocytosis of macrophages in aged mouse through Beclin-1-dependent autophagy. BMC Geriatr. 2021; 21(1):225. doi: 10.1186/s12877-021-02173-2. PMID: 33794800.
17. Xu HD and Qin ZH. Beclin 1, Bcl-2 and Autophagy. Adv Exp Med Biol. 2019; 1206:109-126. doi: 10.1007/978-981-15-0602-4_5.
18. Okuyan HM, Dogan S, Bal T, et al. Beclin-1, an autophagy-related protein, is associated with the disease severity of COVID-19. Life Sci. 2021; 278:119596. doi: 10.1016/j.lfs.2021.119596.
19. Zalckvar E, Berissi H, Mizrachy L, et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep. 2009; 10(3):285-92. doi: 10.1038/embor.2008.246.
20. Chang NC, Nguyen M, Germain M, et al. Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. EMBO J. 2010; 29(3):606-18. doi: 10.1038/emboj.2009.369.
21. Vicencio JM, Ortiz C, Criollo A, et al. The inositol 1, 4, 5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ. 2009; 16(7):1006-17. doi: 10.1038/cdd.2009.34.
Article Sidebar
Published
Nov 25, 2023
Article Details
How to Cite
Ashraf Hassan Abdelmobdy, Saeed Abdelwahab Saeed, Khaled Magdy Mohamed, Marwa Shaban Abd El Samea, Nahed Moawad Ibrahim Rakha. (2023). Assessment of the autophagy biomarker level in Diabetic Kidney Disease Patients. Journal of Population Therapeutics and Clinical Pharmacology, 30(17), 690–701. https://doi.org/10.53555/jptcp.v30i17.3528
Section
Articles
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.