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Chris Amalita F
Dr. Dhivyaa Arunachalam
Haritha Gurusamy Ramasamy
Dr. Narendar Ramesh


Concentrated growth factor, periapical lesion, case control study, extracted socket, soft tissue healing, PRP, PRF, CGF


Background: Concentrated Growth Factor (CGF) in patients undergoing oral surgical procedures with periapical lesion serve as a stimulus for tissue repair, promoting bone and soft tissue recovery.

Aim: Determination of the effectiveness of concentrated growth factor on extracted tooth socket with periapical lesion is the aim of the following study.

Materials and methods: Case control Study conducted in 48 patients aged above 18 years old presented to the Department of Oral & Maxillofacial Surgery for extraction with periapical lesion was evaluated and the efficacy of CGF on extracted tooth socket with periapical lesion. Subjects were assigned into two groups - Group A (Case-CGF) and group B (Control – Conventional treatment.) and were evaluated postoperatively for pain, healing, and assessment of alveolar bone height.

Statistical analysis: Data analysis was done using the software Statistical package for Social Sciences version 26 and recorded as a Mean + Standard deviation.

Results: Pain index between two groups showed mean value in case group was less than control group. Assessment for post-operative soft tissue healing showed mean value for case group is greater than control group with excellent healing in case group. Width of alveolar bone measured at crestal, mid-root, and apical levels showed case group with good growth of alveolar bone evaluated with the control group.

Conclusion: CGF administration in extracted socket with persistent periapical lesions stimulates production of new bone with resolution of inflammation.

Abstract 262 | pdf Downloads 38


1) Aqsa Kamal, Basheer Salman, Noor Hayati Abdul Razak, Ali Al Qabbani, and A.R. Samsudin. The Efficacy of Concentrated Growth Factor in the Healing of Alveolar Osteitis: International Journal of Dentistry.Volume2020.A clinicalStudy.12 May2020,2-6.
2) Nivedhitha Malli Sureshbabu, Aishwarya Ranganath, Benoy Jacob. Concentrated Growth Factor- Surgical Management of Large Periapical Lesion Using a Novel Platelet Concentrate in Combination with Bone Graft. National Library of Medicine Annals of Maxillofacial Surgery.Volume10. January-June2020,246250.
3) Marco Mozzati, Giorgia Gallesio, MargheritaTumedei and MassimoDelFabbro. MDPI. Concentrated Growth Factorvs. Leukocyte-and-Platelet-Rich Fibrin for Enhancing Postextraction Socket Healing. MDPI journal, A Longitudinal Comparative Study. Volume 10.20November2020,1-8.
4) Dilinuer Keranmu, Ailimaierdan Ainiwaer, Nijiati Nuermuhanmode and WangLing -Application of concentrated growthfactor to autotransplantation within flammation in recipient area. BMC Oral Health. 30October 2021,1-9
5) Banu Ozveri Koyuncu, GozdeIsik, Meltem OzdenYuce et al. Effect of concentrated growth factors on frequency of alveolar osteitis following partiallyerupted mandibular third molar surgery : Randomized controlled clinical study . BMC OralHealthvolume20, Articlenumber:222(2020)
6) Ankit Sharma, SnehalIngole, MohanDeshpande et al - Influence of platelet-rich fibrin on wound healing and bone regeneration aftertooth extraction: A clinical and radiographic study - Journal of Oral Biology and Craniofacial Research10 (2020)385-390
7) Numaan Nisar, Kumar Nilesh , Mushtaq Ishaq Parkar, Prashant Punde - Extraction socket preservation using a collagen plug combined with platelet-rich plasma (PRP): A comparative clinico-radiographic study–Journal of Dental Research, Dental clinics,Dental Prospects.
8) William E. Wagner, III - California State University, Channel Islands, USA - Using IBM®SPSS®StatisticsforResearch Methods and Social ScienceS tatistics (7th edition)
9) Lubkowska, B. Dolegowska, and G. Banfi, “Growth factor content in PRP and their applicability in medicine,” Journal of Biological Regulators and Homeostatic Agents, vol. 26, no. 2, pp. 3–22, 2012.
10) Jin R., Song G., Chai J., Gou X., Yuan G., Chen Z. Effects of concentrated growth factor onproliferation, migration, and differentiation of human dental pulp stem cells in vitro. Journal ofTissueEngineering. 2018