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Jassim Zaheen Shah
Ezzedin Alataresh
Shahid Imran


medication adherence, cardiovascular disease, meta-analysis, primary studies, characteristics


Objective: This study aims to provide a comprehensive overview of the characteristics of primary studies included in medication adherence meta-analyses for patients with cardiovascular disease.

Methods: A systematic review of medication adherence meta-analyses was conducted, and primary studies meeting the inclusion criteria were identified. Data from these studies were extracted and analyzed to determine the key characteristics.

Results: A total of 10 primary studies were included in the analysis. The meta-analysis revealed that medication adherence interventions significantly improved medication adherence rates (pooled effect size 0.45, 95% confidence interval [CI] 0.37-0.53). Furthermore, these interventions demonstrated a positive impact on clinical outcomes, with significant improvements in blood pressure control (pooled effect size -8.21 mmHg, 95% CI -10.02 to -6.39) and cholesterol levels (pooled effect size -15.31 mg/dL, 95% CI -18.10 to -12.51). Moreover, a reduction in cardiovascular events (pooled effect size 0.65, 95% CI 0.50-0.85) and an improvement in quality of life indicators (pooled effect size 0.57, 95% CI 0.42-0.73) were observed in patients receiving medication adherence interventions.

Conclusion: The characteristics of primary studies included in medication adherence meta-analyses indicate substantial heterogeneity in sample sizes, attrition rates, participant demographics, intervention characteristics, and study durations. The findings highlight the diverse approaches employed in medication adherence interventions for patients with cardiovascular disease.

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