FACTORS OF DEATH AMONG HOSPITALIZED NEONATES WITH SEPSIS IN THE FLOOD DISASTERS AREAS OF PAKISTAN

Main Article Content

Dr. Muhammad Faiz Ullah
Dr. Mehmoona Shahzadi
Dr. Muhammad Kashif Hafeez
Dr Shaheen Nasira
D. Ayesha Razzaq
Dr. Saira Tasawar

Keywords

Neonates, Sepsis, Pakistan, Death factors, flood

Abstract

Background: Sepsis is the main factor in infant death and neurological impairment among neonates. One-third of all neonatal deaths in Pakistan are attributable to it. Neonates experience a high rate of mortality. Newborn mortality is decreased by identifying and preventing neonatal sepsis predictors.


Objective: The purpose of the study was to identify the factors of death among hospitalized neonates with sepsis during the period of flood disaster.


Methodology: 73 neonates were evaluated at General hospital in the southern Punjab and upper Punjab from June to September 2022. Cases were admitted babies who died from sepsis, whereas controls were those who survived. The deaths of neonates diagnosed with neonatal sepsis were picked in chronological order. The three controls listed below were chosen at random from the NICU case registration book. Information was acquired from baby records using specified checklists. Data was evaluated using SPSS 26. Death variables were examined using logistic regression.


Results: Fifteen cases and fifty-eight controls were included in this study. More than three-quarters of cases (73.4%) had an early start of sepsis. In this investigation, inadequate feeding (AOR = 2.11), respiratory distress (AOR = 1.84), estimated gestational age shorter than 34 weeks (AOR = 5.75), and convulsion (AOR = 2.12) were significantly associated with Death.


Conclusion: This study demonstrated that the causes of sepsis-related infant death were preterm, convulsion, inadequate feeding, and respiratory distress. To lower sepsis-related mortality, it's crucial to pay attention to babies who have any of the identified risks when they're septicemic.

Abstract 108 | PDF Downloads 44

References

1. Iroh Tam PY, Bendel CM. Diagnostics for neonatal sepsis: current approaches and future directions. Pediatric Research. 2017;82(4):574-583. doi:10.1038/pr.2017.134
2. Ahmed M, Yasrab M, Khushdil A, Qamar K, Ahmed Z. NEONATAL SEPSIS IN A TERTIARY CARE HOSPITAL: BACTERIOLOGICAL PROFILE AND ITS ANTIBICROBIAL SENSITIVITY. Pakistan Armed Forces Medical Journal (PAFMJ). 2018;68(6):1654-1658. Accessed October 12, 2022.
https://www.pafmj.org/index.php/PAFMJ/article/view/2566
3. Vergnano S, Buttery J, Cailes B, et al. Neonatal infections: Case definition and guidelines for data collection, analysis, and presentation of immunisation safety data. Vaccine. 2016;34(49):6038-6046. doi:10.1016/j.vaccine.2016.03.046
4. Yadeta D, Semeredin N, Mekonnen GE. Prevalence and Predictors of Atrial Fibrillation and its Embolic Complications in Patients with Rheumatic Heart Disease at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Ethiopian Journal of Health Development. 2019;33(1). doi:10.4314/ejhd.v33i1
5. Fleischmann C, Reichert F, Cassini A, et al. Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis. Archives of Disease in Childhood. Published online January 22, 2021. doi:10.1136/archdischild-2020-320217
6. Getabelew A, Aman M, Fantaye E, Yeheyis T. Prevalence of Neonatal Sepsis and Associated Factors among Neonates in Neonatal Intensive Care Unit at Selected Governmental Hospitals in Shashemene Town, Oromia Regional State, Ethiopia, 2017. International Journal of Pediatrics. 2018;2018:1-7. doi:10.1155/2018/7801272
7. Malik FR, Amer K, Ullah M, Muhammad AS. Why our neonates are dying? Pattern and outcome of admissions to neonatal units of tertiary care hospitals in Peshawar from January, 2009 to December, 2011. JPMA The Journal of the Pakistan Medical Association. 2016;66(1):40-44. Accessed October 12, 2022. https://pubmed.ncbi.nlm.nih.gov/26712179/
8. Mirza Z. Pregnancy, before the flood. DAWN.COM. Published October 7, 2022. Accessed October 12, 2022. https://www.dawn.com/news/1713900
9. Arowosegbe AO, Ojo DA, Dedeke IO, Shittu OB, Akingbade OA. Neonatal sepsis in a Nigerian Tertiary Hospital: Clinical features, clinical outcome, aetiology and antibiotic susceptibility pattern. Southern African Journal of Infectious Diseases. 2017;32(4):127-131. doi:10.1080/23120053.2017.1335962
10. Atrushi AM. THE PROFILE OF NEONATAL SEPSIS IN DUHOK CITY AND PREDICTORS OF MORTALITY: A PROSPECTIVE CASE SERIES STUDY. Duhok Medical Journal. 2018;12(2):10-20. Accessed October 25, 2022.
https://dmj.uod.ac/index.php/dmj/article/view/53
11. Tareen Z, Jirapradittha J, Sirivichayakul C, Chokejindachai W. Factors Associated with Mortality Outcomes in Neonatal Septicemia in Srinagarind Hospital, Thailand. Neonatal and Pediatric Medicine. 2017;03(02). doi:10.4172/2572-4983.1000131
12. Bandyopadhyay T, Kumar A, Saili A, Randhawa VS. Distribution, antimicrobial resistance and predictors of mortality in neonatal sepsis. Journal of Neonatal-Perinatal Medicine. 2018;11(2):145-153. doi:10.3233/npm-1765
13. Yeshaneh A, Tadele B, Dessalew B, et al. Incidence and predictors of mortality among neonates referred to comprehensive and specialized hospitals in Amhara regional state, North Ethiopia: a prospective follow-up study. Italian Journal of Pediatrics. 2021;47(1). doi:10.1186/s13052-021-01139-9
14. Liang L, Kotadia N, English L, et al. Predictors of Mortality in Neonates and Infants Hospitalized With Sepsis or Serious Infections in Developing Countries: A Systematic Review. Frontiers in Pediatrics. 2018;6. doi:10.3389/fped.2018.00277
15. Orsido TT, Asseffa NA, Berheto TM. Predictors of Neonatal mortality in Neonatal intensive care unit at referral Hospital in Southern Ethiopia: a retrospective cohort study. BMC Pregnancy and Childbirth. 2019;19(1). doi:10.1186/s12884-019-2227-5

Most read articles by the same author(s)