FORMULATION AND ASSESSMENT OF A PIPER BETLE EMULGEL FOR ANTIMICROBIAL APPLICATION
Main Article Content
Keywords
Piper betle, Emulgel, Antimicrobial agents, Phytochemical screening, Physicochemical characterization, In vitro drug release, Topical application, Viscosity, Spread ability, Controlled
Abstract
The increasing resistance of microbial strains to existing antimicrobial agents necessitates innovative approaches for effective treatment. This research aims to formulate and evaluate an antimicrobial emulgel using Piper betle leaf extract. The study involved a multi-step methodology comprising leaf collection, extraction, ash value assessment, and phytochemical screening. The emulgels were then formulated using various polymers like Carbopol 934, Carbopol 940, and HPMC. Subsequent physicochemical characterizations were conducted to assess parameters such as pH, viscosity, spreadability, and in vitro drug release. The results revealed a wealth of bioactive compounds in the extract and promising physicochemical properties in the formulated emulgels. The in vitro drug release profiles demonstrated a controlled release mechanism. The findings validate the potential applicability of Piper betle leaf extract-based emulgels in antimicrobial therapy, warranting further research and clinical trials.
References
2. Sabalingam, S., & Siriwardhene, M. A. (2022). A review on emerging applications of emulgel as topical drug delivery system. World Journal of Advanced Research and Reviews, 13(1), 452-463.
3. Keskin Uslu, E., & Yılmaz, E. (2021). Preparation and characterization of oleogels and emulgels with glycerol monooleate–cholesterol mixtures. Chemical Papers, 75(5), 2075-2085.
4. Mantravadi, P. K., Kalesh, K. A., Dobson, R. C., Hudson, A. O., & Parthasarathy, A. (2019). The quest for novel antimicrobial compounds: emerging trends in research, development, and technologies. Antibiotics, 8(1), 8.
5. Biswas, P., Anand, U., Saha, S. C., Kant, N., Mishra, T., Masih, H., ... & Dey, A. (2022). Betelvine (Piper betle L.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes. Journal of Cellular and Molecular Medicine, 26(11), 3083-3119.
6. Budiman, A., & Aulifa, D. L. (2020). A Study Comparing Antibacterial Activity of Ageratum Conyzoides L. extract and Piper Betle L. extract in gel dosage forms against Staphylococcus aureus. Pharmacognosy Journal, 12(3).
7. Burange, P. J., Tawar, M. G., Bairagi, R. A., Malviya, V. R., Sahu, V. K., Shewatkar, S. N., ... & Mamurkar, R. R. (2021). Synthesis of silver nanoparticles by using Aloe vera and Thuja orientalis leaves extract and their biological activity: a comprehensive review. Bulletin of the National Research Centre, 45, 1-13.
8. Peraman, R., Sure, S. K., Dusthackeer, V. N., Chilamakuru, N. B., Yiragamreddy, P. R., Pokuri, C., ... & Chinni, S. (2021). Insights on recent approaches in drug discovery strategies and untapped drug targets against drug resistance. Future Journal of Pharmaceutical Sciences, 7(1), 1-25.
9. Tadić, V. M., Žugić, A., Martinović, M., Stanković, M., Maksimović, S., Frank, A., & Nešić, I. (2021). Enhanced skin performance of emulgel vs. cream as systems for topical delivery of herbal actives (immortelle extract and hemp oil). Pharmaceutics, 13(11), 1919.
10. Guntupalli, G., Rani, G. M., Nori, L. P., & Manikiran, S. S. (2019). Studies on the development of promising herbal emulgel of coccinia grandis leaf extract for dermatalogical complications. Journal of Pharmaceutical Sciences and Research, 11(8), 2915-2920.
11. Pal, N., Mandal, S., Shiva, K., & Kumar, B. (2022). Pharmacognostical, Phytochemical and Pharmacological Evaluation of Mallotus philippensis. Journal of Drug Delivery and Therapeutics, 12(5), 175-181.
12. Ahire, S. M. (2023). Formulation And Evaluation of Herbal Emulgel for The Wound Healing Activity. Latin American Journal of Pharmacy, 42(3), 212-228.
13. Srilal, T. L. I., & Hettihewa, S. K. (2021). Development and Evaluation of a Novel Herbal Emulgel for Potential Anti-Inflammatory and Antioxidant Activities in Vitro.
14. Kola-Mustapha, A. T., Taiwo, S. O., Isiaka, A. R., Amao, S. O., Ishola, I. O., Ghazali, Y. O., & Usman, S. O. (2023). Evaluation of Terminalia macroptera (Combretaceae) Guill. & Perr stem bark extract incorporated into an emulgel for the potential management of rheumatoid arthritis. Scientific African, 19, e01557.
15. Srilal, T. L. I., & Hettihewa, S. K. (2021). Formulation of a novel herbal emulgel using Leea indica (Burm. f.) Merr. (Burulla/Gurulla) leaf extract and evaluation of in vitro anti-inflammatory and antioxidant activities.
16. Srilal, T. L. I., & Hettihewa, S. K. (2021). Formulation of a novel herbal emulgel using Leea indica (Burm. f.) Merr. (Burulla/Gurulla) leaf extract and evaluation of in vitro anti-inflammatory and antioxidant activities.
17. Tadić, V. M., Žugić, A., Martinović, M., Stanković, M., Maksimović, S., Frank, A., & Nešić, I. (2021). Enhanced Skin Performance of Emulgel vs. Cream as Systems for Topical Delivery of Herbal Actives (Immortelle Extract and Hemp Oil). Pharmaceutics 2021, 13, 1919.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Prerna Gupta
Naraina Vidya Peeth Group of Institutions Faculty of Pharmacy, Gangaganj, Panki, Kanpur, India
Alka Maral
Naraina Vidya Peeth Group of Institutions Faculty of Pharmacy, Gangaganj, Panki, Kanpur, India
Dr. Vishal Dubey
Naraina Vidya Peeth Group of Institutions Faculty of Pharmacy, Gangaganj, Panki, Kanpur, India
Shailesh Yadav
Naraina Vidya Peeth Group of Institutions Faculty of Pharmacy, Gangaganj, Panki, Kanpur, India
Shivani Rajbhar
Naraina Vidya Peeth Group of Institutions Faculty of Pharmacy, Gangaganj, Panki, Kanpur, India