DETERMINATION OF CHEMICAL COMPOSITION AND THERAPEUTIC POTENTIAL OF CHICORY (CHICHORIUM INTYBUS) LEAVES POWDER IN MANAGEMENT OF HYPERLIPIDEMIA IN HUMAN SUBJECTS: A RANDOMIZED CONTROL TRIAL

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Dr. Sajeela Akram
Dr. Saira Zafar
Dr. Samina Naeem Khalid
Dr. Umar Farooq
Dr. Hassan Bin Usman Shah
Dr. Madiha Ghazanfar
Dr. Abdul Momin Rizwan Ahmad
Dr. Juweria Abid

Keywords

hypolipidemic effect, Chichorium intybus,, lipid profile, phytochemical analysis

Abstract

Introduction: Hyperlipidemia is characterized as elevated lipid profile parameters. These parameters include cholesterol, triglycerides, low- and high-density lipoprotein this research was done to find out how chicory (Chichorium intybus) leaves powder affected hyperlipidemia.


Objectives: This study's goal was to analyses the chicory leaves powder's chemical make-up along with phytochemical contents.


Material and methods: Three groups were taken for the study with the name of control and treatment groups. Each group contain the equal no of hyperlipidemic patients on the basis of their inclusion and exclusion criteria. Treatment groups I and II received encapsulated doses of 20 mg and 40 mg of chicory leaves powder while control group were not taking anything. Biochemical profiles with special reference to lipid profile values of studied subjects were assessed and compared at 0 and 8 weeks. In IBM SPSS Statistics 20, ANOVA was used to assess each result.


Results: Proximate tests revealed that chicory leaves powder had 6.50.08 protein, 30.191.02 fiber, 5.010.23 ash, and 8.090.31 moisture, whereas nitrogen free extract comprised 44.311.17. Calcium and manganese were found to be the most abundant minerals in chicory leaf powder, according to mineral analysis. Chicory leaf powder contained 11.9 and 9.01 mg/g of total phenolic and total flavonoids compounds (TCF & TFC), respectively.


Conclusion: Phytochemicals and proximate analysis of chicory leaves confirmed that its use can cause a significant reduction in lipid profile indices triglycerides, cholesterol, and low-density lipoproteins with an increase in high density lipoproteins. At p0.05, all results were considered significant.

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