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Prof Dr Saher Fatima Fatima
Prof Dr Anjum Rehman
Dr Zeeshan Ahmed
Ms Ambreen Rehman
Ms Habiba Rehman


Oral Labetalol, Curry Leaves (KadiPatta), Pregnancy induced hypertension


OBJECTIVE:To compare the fetomaternal outcome of oral labetalol versus Labetalol with oral eating murraya koengii/curry leaves (KadiPatta) in pregnancy induced hypertensionpatients.

MATERIAL & METHOD: This cohort study was conducted from March 2019 to February 2022 at the Department of Obstetrics & Gynecology, Lyari General Hospital Karachi. All pregnant patients who were diagnosed with pregnancy induced hypertension, such systolic BP of ≤160mmHg or diastolic BP of ≤110mmHg admitted and case entry after written informed consent has been done. Chronic hypertension, history of cardiac abnormality, and intrauterine death were excluded before 28th week from this study. Preliminary results were measured for BP control and the number of doses needed. Secondary outcome measures were maternal complications of placental abruption, HELLP, and eclampsia.

RESULTS: A total of 1000 patients were recruited in this randomized controlled study. The mean age was 29.2±7.33 years in group A and 29.58±7.90 years in Group B. Most of the patients with a primigravida, 29.58±7.90 and 362(72.4%) were Group A and B respectively. Common maternal side effects encountered were palpitation seen in 66(13.2%) patients of Group-A and 44(8.8%) patients in Group-B (p=0.021). Followed by headache were seen in 42(8.4%) patients of Group-A, 33(6.6%) patients of Group B. Placental Abruption in 42(8.4%) patients were observed in Group A, while in 25(5%) patients in Group B (p=0.213). Eclampsia was seen in 28(5.6%) patients in Group-A and 22(4.4%) patients developed eclampsia in Group B (p=0.011). In Labetalol Group, 67(13.4%) babies had APGAR Score ≤7 and 131(26.2%) babies required admission to NICU. In In labetalol with curry leaves group-B 56(11.2%) babies had Apgar score ≤7 & 106(21.2%) babies were admitted to NICU (p= 0.003). Early Neonatal Deaths and Intrauterine Death was observed 39(7.8%)  in labetalol with curry leaves group-B, followed by still birth in 8(1.6%)babies. While in group A 51(10.2%) babies were early neonatal deaths and 12(2.4%) babies still birth .

CONCLUSION: Oral labetalowith Curry Leaves (KadiPatta) is efficacious in controlling BP in patients with induced hypertension patients without any significant side effects.

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