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Muhammad Hamza
Salman Zahir
Aneela Khan
Sarwat Jahan
Daniyal Ahmed
Khansa Khan


Thalassemia, Hypersplenism, Transfusion-Dependent Thalassemia, Splenectomy


Transfusion-dependent thalassemia is a chronic disease that affects many individuals and has a significant impact on the healthcare system and society. This study sought to explore the prevalence and factors contributing to hypersplenism in transfusion-dependent thalassemia patients in the Khyber Pakhtunkhwa province of Pakistan. A single-center-based retrospective study was conducted on 50 randomly selected patients over a period of three months From February 2019 to April 2019 and data was analyzed using established statistical techniques. The results showed that all (n=50, 100%) of the participants developed hypersplenism at an average age of 6.86±1.9 years and underwent a splenectomy at an average age of 15.1±4.6 years. The study found that the average number of annual transfusions received by the patients was 19.1±7.7, with no significant change in transfusion frequency after splenectomy

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