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Dr Shubhra Sengupta
Dr Sunita R Bhandari


Hepatitis B (HBV), Immunoassay, Seroprevalence


Background: Infection with the Hepatitis B Virus (HBV) is a global health problem. Epidemiological studies worldwide show wide variations in the prevalence patterns of the Hepatitis B infections. Hepatitis caused by hepatitis B virus is potentially a fatal liver infection. It causes acute and chronic liver disease and puts people at high risk of death from cirrhosis and hepato-cellular carcinoma. Early detection can timely diagnosis of the patients with early treatment, can limit the transmission of the infection.

Aim: To estimate HbsAg sero-positivity among patient attending tertiary care centre.

Materials and Methods: Present study was conducted in department of microbiology at tertiary care centre from June  2021 to  June 2022. A total of 23760 samples were tested for hepatitis B surface antigen using CLIA (Chemiluminescent immunoassays) quantitative method. Details of various sociodemographic variables of the patients were collected. The test results of the patient were noted and analyzed.

Results:  Out of 23760 sera which were studied, 792 (3.33%) were sero-positive cases. Among the positive cases (792), the seroprevalence in males and females were 70% (554) and  30% (238) respectively and the frequency of HBV among age groups 0-20 , 21-40, 41-60, >60 was 7.57% (60), 49.24% (390), 31.56% (250),11.61% (92) respectively. Among the positive cases, a majority were in the age group of 21 to 40 years. The Seroprevalence over one year was found to be 3.33%

Conclusions: Present study highlights the prevalence of hepatitis B infection among patients attending tertiary care centre.  The overall prevalence for this HBsAg marker among the patients who attended the rural tertiary teaching hospital in this study was comparatively similar to that which was reported by other studies from India.

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