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Baydaa Yonus Ibrahim
Almaz Muwafq Hachim
Layla Hazim Saeed


Vitamin, pregnancy, deficiency, fetal, outcome


Many people are now interested in the importance of vitamin D because it does more than just help regulate calcium levels. More and more studies are being done to understand how vitamin D during pregnancy supports various aspects of health, as well as the consequences of not having enough of it. The goal of this research is to find out how common vitamin D deficiency is among pregnant women and the effects it has on both the mother and the baby.

Patients and Methods: 200 women who were about to give birth were chosen to participate in a study while they were in the hospital. We gathered information about the health of all the participants from their medical records. They also kept track of when the babies were born and what happened during delivery. A blood test that measures how much vitamin D is in the body. The enzyme-linked immunosorbent assay is a test that uses enzymes to find and measure things in the body, like antibodies or antigens.

Results: Out of all the cases, 9 had a good level of vitamin D, 20 had a bit of a low level, and 171 had a very low level. The groups had similar information about the people's characteristics and reproductive history, and the differences between the groups were not significant. There were no significant differences in vitamin D levels among those who had higher body weight, gestational diabetes, pre-eclampsia, and growth problems in the baby in the womb. But, women who did not have enough vitamin D were more likely to have high blood pressure during pregnancy. There were not many differences in how babies were born and how they did soon after birth for women with different amounts of vitamin D.

Conclusion: Not having enough vitamin D is a common health problem in pregnant women in Iraq and is called hypovitaminosis D. When a woman is pregnant and has low weight, there is a greater possibility that she may develop gestational hypertension, which is a negative condition. 25(OH)D is a type of vitamin D that is checked in the blood.

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1. Hyppönen E, Cavadino A, Williams D, Fraser A, Vereczkey A, Fraser WD, et al. Vitamin D and pre-eclampsia: original data, systematic review and meta-analysis. Ann Nutr Metab [Internet] 2013;63(4):331–40
2. Wang XY, Liu LM, Li YF. Effect of vitamin D deficiency among urban pregnant women on their neonates in Xi'an. Chinese Journal of Woman and Child Health Research 2012; 23: 20–22
3. Xie EF, Jiang L, Xu J, et al. Differences in the levels of serum 25 - hydroxyl vitamin D of pregnant women in winter and summer in nanjing area. Chinese Journal of Perinatal Medicine 2013; 16: 100–101
4. Lips P. Worldwide status of vitamin D nutrition. J Steroid Biochem Mol Biol 2010; 121: 297–300.
5. Bassil D, Rahme M, Hoteit M, et al. Hypovitaminosis D in the Middle East and North Africa: Prevalence, risk factors and impact on outcomes. Dermatoendocrinol 2013; 5: 274–298
6. Hong-Bi S, Yin X, Xiaowu Y, Ying W, Yang X, Ting C, Na W. High prevalence of vitamin D deficiency in pregnant women and its relationship with adverse pregnancy outcomes in Guizhou, China. J Int Med Res. 2018 Nov;46(11):4500-4505. doi: 10.1177/0300060518781477. Epub 2018 Oct 1. PMID: 30270806; PMCID: PMC6259374
7. Rodriguez A, Garcia-Esteban R, Basterretxea M, Lertxundi A, Rodriguez-Bernal C,Iniguez C, et al. Associations of maternal circulating 25-hydroxyvitamin D3 concentration with pregnancy and birth outcomes. BJOG. 2015;122:1695–704.
8. Flood-Nichols SK, Tinnemore D, Huang RR, Napolitano PG, Ippolito DL.Vitamin D deficiency in early pregnancy. PLoS One. 2015;10:e0123763.
9. Yap C, Cheung NW, Gunton JE, Athayde N, Munns CF, Duke A, et al.Vitamin D supplementation and the effects on glucose metabolism during pregnancy: a randomized controlled trial. Diabetes Care.2014;37:1837–44.
10. Bodnar LM, Simhan HN, Catov JM, Roberts JM, Platt RW, Diesel JC, et al.Maternal vitamin D status and the risk of mild and severe preeclampsia.Epidemiology. 2014;25:207–14
11. Perez-Lopez FR, Pasupuleti V, Mezones-Holguin E, Benites-Zapata VA, Thota P, Deshpande A, et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril. 2015;103:1278–88.
12. Thorne-Lyman A, Fawzi WW. Vitamin D during pregnancy and maternal,neonatal and infant health outcomes:a systematic review and meta-analysis.Paediatr Perinat Epidemiol. 2012;26:75–90.
13. Bener A, Al-Hamaq AO, Saleh NM. Association between vitamin D insufficiency and adverse pregnancy outcome: global comparisons. Int J Womens Health. 2013;5:523–31.
14. Guariguata L, Linnenkamp U, Beagley J, Whiting DR, Cho NH. Global estimates of the prevalence of hyperglycaemia in pregnancy. Diabetes Res Clin Pract. 2014;103:176–85.
15. Wei SQ, Qi HP, Luo ZC, Fraser WD. Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2013;26:889–99.
16. Zhang C, Qiu C, Hu FB, David RM, van Dam RM, Bralley A, et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One. 2008;3:e3753.
17. Hossein-Nezhad A, Maghbooli Z, Vassigh AR, Larijani B. Prevalence of gestational diabetes mellitus and pregnancy outcomes in Iranian women.Taiwan J Obstet Gynecol. 2007;46:236–41.
18. Clifton-Bligh RJ, McElduff P, McElduff A. Maternal vitamin D deficiency,ethnicity and gestational diabetes. Diabet Med. 2008;25:678–84.
19. Karras SN, Anagnostis P, Naughton D, Annweiler C, Petroczi A, Goulis DG.Vitamin D during pregnancy: why observational studies suggest deficiency and interventional studies show no improvement in clinical outcomes? A narrative review. J Endocrinol Invest. 2015;38:1265–75
20. Karras SN, Anagnostis P, Annweiler C, Papadopoulou F, Persynaki A, Goulis DG. Maternal vitamin D status during pregnancy: the Mediterranean reality. Eur J Clin Nutr. 2014;68:864–9.
21. Brown MA, Lindheimer MD, de Swiet M, Van Assche A, Moutquin JM. The classification and diagnosis of the hypertensive disorders of pregnancy:statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy. 2001;20:IX–XIV.
22. Holick MF. Vitamin D, deficiency. N Engl J Med. 2007;357:266–81.
23. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab.2011;96:1911–30
24. Umar M, Sastry KS, Chouchane AI. Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies. Int J Mol Sci. 2018 May 30;19(6):1618. doi: 10.3390/ijms19061618. PMID: 29849001; PMCID: PMC6032242.
25. Arshad R, Sameen A, Murtaza MA, Sharif HR, Iahtisham-Ul-Haq, Dawood S, Ahmed Z, Nemat A, Manzoor MF. Impact of vitamin D on maternal and fetal health: A review. Food Sci Nutr. 2022 Jul 7;10(10):3230-3240. doi: 10.1002/fsn3.2948. PMID: 36249984; PMCID: PMC9548347.
26. Zhang H, Wang S, Tuo L, Zhai Q, Cui J, Chen D, Xu D. Relationship between Maternal Vitamin D Levels and Adverse Outcomes. Nutrients. 2022 Oct 11;14(20):4230. doi: 10.3390/nu14204230. PMID: 36296914; PMCID: PMC9610169.

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