RHABDOMYOLYSIS DUE TO AN UNCOMMON INTERACTION OF CIPROFLOXACIN WITH SIMVASTATIN

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Sawant , RD RD

Keywords

Simvastatin, ciprofloxacin, rhabdomyolysis, elderly, polypharmacy

Abstract

A case report of a ciprofloxacin and simvastatin interaction is presented. The addition of ciprofloxacin to chronic  simvastatin  therapy  led  to  the  development  of  rhabdomyolysis.  As  ciprofloxacin  is  a  weak inhibitor of CYP3A4, it is very likely that other mechanisms involving the ATP-binding cassette drug efflux transporter family played a role in this drug interaction

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