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Sucheta S. Pawar
Atish B. Velhal
Vitthal J. Chaware
Vivekkumar K. Redasani


Amalgamation, of, tridax, procumbens, and ginger, juice, heptoprotection, paracetamol, rats, SGOT, SGPT, ALP


The hepatoprotective activity of amalgamation of tridax procumbens and ginger juice was evaluated against paracetamol induced hepatotoxicity in rats. The albino wistar rats (n = 30) were randomly divided into 6 groups (n = 5). Group I (Normal control) did not receive any treatment. Group II (Toxic control) animals were administered with paracetamol (2.75g/kg p.o.) on 6th and 7th day. Group III rats pretreated with silymarin at a dose of 50 mg/kg b. w. /day for 7 days and were induced with Paracetamol at dose 2.75g/kg p.o. on 6th and 7th day. Group IV rats pretreated with ethanolic extract of tridax procumbens at dose 200mg/kg for 7 days and were induced with paracetamol at dose 2.75g/kg p.o. on 6th and 7th day . Group V rats pretreated with ginger juice at dose 2ml/kg for 7 days and were induced with paracetamol at dose 2.75g/kg p.o. on 6th and 7th day. Group VI pretreated with ethanolic extract of tridax procumbens and ginger juice at 200 mg/kg and 2ml/kg dose b. w. /day for 7days and were induced with paracetamol at dose 2.75g/kg p.o. on 6th and 7th day. Liver function tests, triglyceride, MDA, glutathione and electrolyte profile were estimated using standard kits. Livers were quickly removed and fixed in 10% formalin and subjected to histopathological studies. In conclusion, the amalgamation of tridax procumbens and ginger juice can enhance antioxidant activity and ameliorate the paracetamol-induced hepatotoxicity. The results of this study strongly indicate that Amalgamation of tridax procumbens and ginger juice has got a potent hepatoprotective action against paracetamol induced hepatic damage in rats.

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