COMPARING DEFERASIROX AND DESFERRIOXAMINE AS IRON CHELATORS IN PATIENTS WITH BETA-THALASSEMIA MAJOR

Main Article Content

Zoah Syed
Muhammad Hamza Asif
Rida Waheed
Aleena Haider
Mubarik Ahmed Ayub
Sidrah

Keywords

Iron, Therapies, Hypertension, DFX, DFO, Beta-thalassemia

Abstract

 Thalassemia which is one of the most common severe genetic blood disorders can lead to different ocular involvements.
Objectives: The basic aim of the study is to compare the deferasirox and desferrioxamine as iron chelators in patients with beta-thalassemia major.


Material and methods: This retrospective observational study was conducted in the medicine department of Services Hospital, Lahore from April 2022 to March 2023. The study included a total of 220 patients diagnosed with beta-thalassemia major who were undergoing iron chelation therapy with either DFX or DFO during the study period. Demographic information, including age, gender, and ethnicity, was recorded for each patient. Clinical characteristics, such as the date of betathalassemia major diagnosis, transfusion history, serum ferritin levels, liver and cardiac function assessments, and the presence of comorbidities, were meticulously documented.
Results: Data was collected from 220 patients, with 120 (54.5%) receiving Deferasirox (DFX) and 100 (45.5%) receiving Desferrioxamine (DFO). The study population had a mean age of 28.5 years, with 120 (54.5%) males and 100 (45.5%) females. 75 (34.1%) of patients had comorbidities, including diabetes mellitus, hypertension, and hypothyroidism. The change in serum ferritin levels from baseline to the end of the study period was 1250 ng/mL in the DFX group and 1650 ng/mL in the DFO group (p-value: 0.032).
Conclusion: It is concluded that, both Deferasirox (DFX) and Desferrioxamine (DFO) are effective iron chelation therapies for patients with beta-thalassemia major. DFX demonstrated a significant reduction in serum ferritin levels compared to DFO, but both therapies had similar effects on liver iron concentration and cardiac iron load.

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