ANALYSING SHORT- AND LONG-TERM MORTALITY FACTORS IN STEMI PATIENTS TREATED WITH PRIMARY PCI

Main Article Content

Dr. Aamir Nawaz khan
Dr. Asfandiar Ali
Dr. Abdul Samad Khan
Dr. Farhan Mahmood Gul
Dr. Adil Zulfiqar

Keywords

Analysing, STEMI, patients, PCI, ST-segment

Abstract

Introduction: Primary percutaneous coronary intervention (PCI) is the preferred initial treatment of patients presenting with ST-segment elevation myocardial infarction (STEMI) within 12 h of symptom onset, provided treatment can be initiated expeditiously by an experienced team.


Objectives: The main objective of the study is to find the short- and long-term mortality factors in STEMI patients treated with primary PCI.


Material and methods: This retrospective study was conducted in Lady Reading Hospital Peshawar during December 2022 to May 2023. Data was collected from 180 patients. Data collection for this study was conducted systematically and comprehensively. Electronic medical records from hospital data were rigorously reviewed to extract relevant information from 80 patients meeting the inclusion criteria.


Results: Data was collected from 180 patients according to inclusion and exclusion criteria. The mean age of the cohort was 60.5 years, with 70% being male. Common comorbidities included hypertension (45%), diabetes mellitus (30%), and a history of prior cardiac events (25%). In the short-term (in-hospital) analysis, 10% of patients

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References

References
1. Steg, P. G., James, S. K., Atar, D., Badano, L. P., Lundqvist, C. B., ... &Wallentin, L. (2012). ESC Guidelines forthe management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC). European heart journal, 33(20), 2569-2619.
2. Terkelsen, C. J., Sørensen, J. T., Maeng, M., Jensen, L. O., Tilsted, H. H., Trautner, S., ... &Lassen, J. F. (2010). System delay and mortality among patients with STEMI treated with primary percutaneous coronary intervention. Jama, 304(7),763-771.
3. Pedersen, Frants; Butrymovich, Vitalij; Kelbæk, Henning; Wachtell, Kristian; Helqvist, Steffen; Kastrup, Jens; Holmvang, Lene; Clemmensen, Peter; Engstrøm, Thomas; Grande, Peer; Saunamäki, Kari; Jørgensen, Erik (2014). Short- and Long-Term Cause of Death in Patients Treated With Primary PCI for STEMI. Journal of the American College of Cardiology, 64(20), 2101–2108. doi:10.1016/j.jacc.2014.08.037
4. Sabroe, J.E., Thayssen, P., Antonsen, L. et al. Impact of renal insufficiency on mortality in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. BMC Cardiovasc Disord 14, 15 (2014). https://doi.org/10.1186/1471-2261-14-15
5. Smith, S. W., et al. (2020). Prognostic Value of the Shock Index in Patients With STEMI: A Systematic Review. Journal of the American College of Cardiology, 76(9), 1025-1038.
6. Katakami, N., et al. (2019). Diabetes Mellitus, Glycemic Control, and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction. Circulation Journal, 83(7), 1433-1441.
7. Danchin N, Popovic B, Puymirat E, et al. Five-Year outcomes following timely primary percutaneous intervention, late primary percutaneous intervention, or a pharmaco-invasive strategy in ST-segment elevation myocardial infarction: the FAST-MI programme. Eur Heart J 2020;41:85866.doi:10.1093/eurheartj/ehz665pmid:http://www.ncbi.nlm.nih.gov/pubmed/31539043
8. Kaifoszova Z, Kala P, Alexander T, et al. Stent for life initiative: leading example in building STEMI systems of care in emerging countries. EuroIntervention 2014;10 Suppl T:T8795.doi:10.4244/EIJV10STA14pmid:http://www.ncbi.nlm.nih.gov/pubmed/25256540
9. Gao, M., Cheng, Y., Zheng, Y., Zhang, W., Wang, L., & Qin, L. (2017). Association of serum transaminases with short-and long-term outcomes in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. BMC cardiovascular disorders, 17(1), 1-8.
10. Ahmed, T., Tahir Saghir, N. A., Shahzad, F. F. M., & Shaikh, A. H. (2022). Short-and Long-Term Cause of Death in Patients Treated with Primary PCI for STEMI. Pakistan Journal of Medical & Health Sciences, 16(09), 705-705.
11. Piacková, E., Jäger, B., Farhan, S., Christ, G., Schreiber, W., Weidinger, F., ... & Huber, K. (2017). Gender differences in short-and long-term mortality in the Vienna STEMI registry. International journal of cardiology, 244, 303-308.
12. Mandurino-Mirizzi, A., Cornara, S., Somaschini, A., Demarchi, A., Galazzi, M., Puccio, S., ... & De Ferrari, G. M. (2021). Elevated serum uric acid is associated with a greater inflammatory response and with short-and long-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Nutrition, Metabolism and Cardiovascular Diseases, 31(2), 608-614.
13. Entezarjou, A., Mohammad, M. A., Andell, P., &Koul, S. (2018). Culprit vessel: impact on short-term and long-term prognosis in patients with ST-elevation myocardial infarction. Open Heart, 5(2), e000852.
14. Yamashita, Y., Shiomi, H., Morimoto, T., Yaku, H., Furukawa, Y., Nakagawa, Y., ... & Kimura, T. (2017). Cardiac and noncardiac causes of long-term mortality in ST-segment–elevation acute myocardial infarction patients who underwent primary percutaneous coronary intervention. Circulation: Cardiovascular Quality and Outcomes, 10(1), e002790.
15. Watanabe, H., Ozasa, N., Morimoto, T., Shiomi, H., Bingyuan, B., Suwa, S., ... & CAPITAL-RCT investigators. (2018). Long-term use of carvedilol in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. PLoS One, 13(8), e0199347.
16. Vrsalovic, M., Pintaric, H., Babic, Z., Pavlov, M., Presecki, A. V., Getaldic, B., ... &Heitzler, V. N. (2012). Impact of admission anemia, C-reactive protein and mean platelet volume on short term mortality in patients with acute ST-elevation myocardial infarction treated with primary angioplasty. Clinical biochemistry, 45(16-17), 1506-1509.
17. Elias, J., Van Dongen, I. M., Råmunddal, T., Laanmets, P., Eriksen, E., Meuwissen, M., ... &Hoebers, L. P. (2018). Long-term impact of chronic total occlusion recanalisation in patients with ST-elevation myocardial infarction. Heart, 104(17), 1432-1438.
18. Karabağ, Y., Çağdaş, M., Rencuzogullari, I., Karakoyun, S., Artaç, İ., İliş, D., ... &Tanboğa, I. H. (2018). Comparison of SYNTAX score II efficacy with SYNTAX score and TIMI risk score for predicting in-hospital and long-term mortality in patients with ST segment elevation myocardial infarction. The International Journal of Cardiovascular Imaging, 34, 1165-1175.
19. Liang, J. J., Fender, E. A., Cha, Y. M., Lennon, R. J., Prasad, A., &Barsness, G. W. (2016). Long-term outcomes in survivors of early ventricular arrhythmias after acute ST-elevation and non–ST-elevation myocardial infarction treated with percutaneous coronary intervention. The American journal of cardiology, 117(5), 709-713.
20. Keeley, E. C., Mehran, R., Brener, S. J., Witzenbichler, B., Guagliumi, G., Dudek, D., ... & Stone, G. W. (2014). Impact of multiple complex plaques on short-and long-term clinical outcomes in patients presenting with ST-segment elevation myocardial infarction (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction [HORIZONS-AMI] Trial). The American journal of cardiology, 113(10), 1621-1627.