A Comparative Evaluation of Xenograft, Platelet Rich Fibrin And Guided Tissue Regeneration Membrane In The Treatment Of Mandibular Grade II Furcation Defects

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“Grade-II mandibular furcation defects, PRF, GTR, Xenograft, CBCT”.


One of the most exacting facets in therapy of periodontitis is the regeneration of periodontium affected by tooth furcation involvement. The furcation region has a complex anatomy that requires the use of specialized instruments called furcation curettes to treat it. Grade-II mandibular furcation defects are furthermore amenable to treatment and various techniques and materials have been employed to treat them with moderate success.

AIM: The current study aimed to compare the surgical outcome of grade II furcation therapy with xenograft alone, xenograft along with GTR and xenograft along with PRF membrane.

MATERIALS AND METHODS: This was a corresponding arm prospective randomized and interventional trial conducted within 18 different patients (27 defects) possessing Grade- II mandibular tooth furcation defects. The patients were spitted into three groups. In Group A, 6 patients with 9 defects have been treated by the positioning of Xenograft while in the Group B, 6 patients with 9 defects were treated by the positioning of Xenograft as graft and Guided Tissue Regeneration membrane while in Group C, 6 patients with 9 defects were treated by the positioning of Xenograft as graft and PRF as membrane. Clinical specifications including “Plaque Index (PI)”, “Probing Depth (PD)”, “Relative Vertical Clinical Attachment Level (RVCAL)”, “Relative Horizontal Clinical Attachment Level (RHCAL)”, and quantity of Bone fill by using CBCT, were approximated at baseline and Six months post-operatively. Differentiation between the groups was analyzed by employing ANNOVA test, whereas the paired t-test was used to analyse the mean values within the groups.

RESULTS: On comparing those results between the groups it was observed that excepting from the Probing pocket depth (PD) and Depth of defect fill all other specifications were not arithmetically significant. The Probing depth  inbetween the groups at baseline (5.73±0.79) in Group-A, 6.18 ± 0.75 in Group B) and (6.09±0.70)  was not arithmetically significant, however after six months it was observed that in group A it was 1.73±0.79 , in the  group B 1.36±0.50 and in the group C 2.09± 0.70 which was arithmetically significant (p<0.05). Similarly, the depth of the defect between the groups at baseline (3.67 ± 0.44 in the Group A, 3.95 ± 0.70 in the Group B and 3.46 ± 0.43 in the Group C) were not statistically remarkable, however 6 months postoperatively it was observed that in group A, the defect fill was1.51 ±0.34, in group B it was 1.26±0.26 and in group C it was 1.35± 0.27 which was arithmetically significant. (p<0.05).

CONCLUSION: Xenograft alone (Group A) Xenograft and Guided Tissue Regeneration membrane (Group B) Xenograft and Platelet Rich Fibrin membrane (Group C) were biocompatible with the tissues. There was a well-defined improvement in all the specifications assessed in all the three of the groups. However, patients in the Group B have showed better results than in Group C and in Group A.

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