PRF: EMPOWERING PERIODONTAL REGENERATION FROM WITHIN
Main Article Content
Keywords
Platelet-rich fibrin (PRF), Periodontics, Periodontal regeneration
Abstract
In periodontology, platelet-rich fibrin (PRF) has become a useful add-on therapy with the goal of accelerating periodontal tissue regeneration and repair. PRF is a concentrated form of platelets, growth factors, and cytokines, an autologous preparation made from the patient's own blood. Due to its distinctive makeup, PRF can successfully encourage tissue regeneration and healing after a variety of periodontal procedures. It can enhance the results of treatments like guided tissue regeneration and bone grafting by acting as a natural scaffold to assist with the growth of new bone and connective tissue. PRF has been shown to accelerate soft tissue healing, lessen postoperative pain, and reduce swelling and inflammation. Its use in procedures including implant placement, gingival recession coverage, and flap surgeries have demonstrated enhanced wound healing and aesthetic results. The ability of PRF to create an advantageous milieu rich in cytokines and growth factors aids in improving the results of different periodontal procedures.
References
1. W.V. Giannobile-The potential role of growth and differentiation factors in periodontal regeneration. J Periodontol, 67 (1996), p. 545e53
2. H. Greenwell-Committee on research, science and therapy, American Academy of Periodontology. Position paper: guidelines for periodontal therapy. J Periodontol, 72 (2001), pp. 1624-1628
3. L. Sander, T. Karring. Healing of periodontal lesions in monkeys following the guided tissue regeneration procedure. A histological study. J Clin Periodontol, 22 (1995), pp. 332-337
4. A.K. Deodhar, R.E. Rana. Surgical physiology of wound healing: a review. J Postgrad Med, 43 (1997), pp. 52-56
5. W.V. Giannobile. Periodontal tissue engineering by growth factors. Bone, 19 (Suppl. 1) (1996), pp. 23S-37S
6. D.M. Dohan, J. Choukroun, A. Diss, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate, part I: technological concept and evolution. Oral Surg Oral Med Oral Path Oral Radiol Endod, 101 (2006), pp. E37-E44
7. Ross R, Glomset J, Kariya B, Harker L. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci U S A. 1974;71:1207–1210. [PMC free article] [PubMed] [Google Scholar]
8. Kiran NK, Mukunda KS, Tilak Raj TN. Platelet concentrates: A promising innovation in dentistry. J Dent Sci Res. 2011;2:50–61.
9. Whitmann DH, Berry RL, Green DM. Platelet gel: an alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg. 1997;55:1294–1299. [PubMed]
10. Choukroun J, Adda F, Schoeffler C, Vervelle A. Une opportunité en paro-implantologie: le PRF. Implantodontie. 2000;42:55–62. [Google Scholar]
11. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e37–44. [PubMed]
12. Harrison P. Platelet function analysis. Blood Rev. 2005;19:111–123. [PubMed]
13. Castro HC, Ferreira BLA, Nagashima T, Schueler A, Rueff C, Camisasca D, Moreira G, Scovino G, Borges L, Leal M, Filgueira M, Paschoal P, Bernardo V, Bourguinhon S, Rodrigues CR, Santos DO. Plaquetas: ainda um alvo terapêutico. J Bras Patol Med Lab. 2006;42:321–332. [
14. Fernández-Delgado N, Hernández-Ramírez P, Forrellat-Barrios M. Platelet functional spectrum: from hemostasis to regenerative medicine. Rev Cubana Hematol Inmunol Hemoter. 2012;28:200–216.
15. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e45–50.
16. Garcia VG, Corral I, Bascones-Martínez A. Plasma rico en plaquetas y su utilización en implantología dental. Av Period. 2004;16:81–92.
17. Gupta V, Bains BK, Singh GP, Mathur A, Bains R. Regenerative potential of platelet rich fibrin in dentistry: Literature review. Asian J Oral Health Allied Sci. 2011;1:22–28.
18. Gassling V, Douglas T, Warnke PH, Açil Y, Wiltfang J, Becker ST. Platelet-rich fibrin membranes as scaffolds for periosteal tissue engineering. Clin Oral Implants Res. 2010;21:543–549.
19. Laurens N, Koolwijk P, de Maat MP. Fibrin structure and wound healing. J Thromb Haemost. 2006;4:932–939. [PubMed]
20. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e45–50. [PubMed]
21. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e56–60. [PubMed]
22. Li Q, Pan S, Dangaria SJ, Gopinathan G, Kolokythas A, Chu S, Geng Y, Zhou Y, Luan X. Platelet-rich fibrin promotes periodontal regeneration and enhances alveolar bone augmentation. Biomed Res Int. 2013;2013:638043. [PMC free article] [PubMed]
23. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e51–55. [PubMed]
24. Chang YC, Zhao JH. Effects of platelet-rich fibrin on human periodontal ligament fibroblasts and application for periodontal infrabony defects. Aust Dent J. 2011;56:365–371. [PubMed]
25. Kawase T, Kamiya M, Kobayashi M, Tanaka T, Okuda K, Wolff LF, Yoshie H. The heat-compression technique for the conversion of platelet-rich fibrin preparation to a barrier membrane with a reduced rate of biodegradation. J Biomed Mater Res B Appl Biomater. 2015;103:825–31. [PubMed]
26. Wu CL, Lee SS, Tsai CH, Lu KH, Zhao JH, Chang YC. Platelet-rich fibrin increases cell attachment, proliferation and collagen-related protein expression of human osteoblasts. Aust Dent J. 2012;57:207–212. [PubMed]
27. Saluja H, Dehane V, Mahindra U. Platelet-Rich fibrin: A second generation platelet concentrate and a new friend of oral and maxillofacial surgeons. Ann Maxillofac Surg. 2011;1:53–57. [PMC free article] [PubMed]
28. Bölükbaşı N, Ersanlı S, Keklikoğlu N, Başeğmez C, Ozdemir T. Sinus augmentation with platelet-rich fibrin in combination with bovine bone graft versus bovine bone graft in combination with collagen membrane. J Oral Implantol. 2013 [Epub ahead of print] [PubMed]
29. Joseph VR, Sam G, Amol NV. Clinical evaluation of autologous platelet rich fibrin in horizontal alveolar bony defects. J Clin Diagn Res. 2014;8:ZC43–47. [PMC free article] [PubMed]
30. Kim TH, Kim SH, Sándor GK, Kim YD. Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing. Arch Oral Biol. 2014;59:550–558. [PubMed]
31. Simonpieri A, Del Corso M, Vervelle A, Jimbo R, Inchingolo F, Sammartino G, Dohan Ehrenfest DM. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: Bone graft, implant and reconstructive surgery. Curr Pharm Biotechnol. 2012;13:1231–1256. [PubMed]
32. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: From pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF) Trends Biotechnol. 2009;27:158–67. [PubMed
33. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: From pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF) Trends Biotechnol. 2009;27:158–67. [PubMed]
34. Anitua et al., Sanchez M, Orive G, Andia I. (2007): The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials.28:4551–4560.
35. Dohan et al., Choukroun J, Diss A (2006c): Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part III: Leucocyte activation: A new feature for platelet concentrates? Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology 101(3): e51-e55.
36. Dohan et al., Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J. (2006b): Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod.101:e45–e50.
37. Dohan et al., Del Corso M, Diss A, Mouhyi J, Charrier J-B. (2010): Three-Dimensional Architecture and Cell Composition of a Choukroun’s Platelet-Rich Fibrin Clot and Membrane. J Periodontol 81(4): 546-555.
38. Monitha G, Pavan B, Oza RR. Injectable Platelet-Rich Fibrin-A Revolution in Periodontal Regeneration. Cureus. 2022;14(8).
39. Pavlovic V, Ciric M, Jovanovic V, Trandafilovic M, Stojanovic P. Platelet-rich fibrin: Basics of biological actions and protocol modifications. Open Medicine. 2021 Mar 22;16(1):446-54.
40. Everts PA, Hoffmann J, Weibrich G, Mahoney CB, Schönberger JP, van Zundert A, et al. Differences in platelet growth factor release and leucocyte kinetics during autologous platelet gel formation. Transfus Med. 2006;16:363–8. [PubMed] [Google Scholar]
41. Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB. Three-dimensional architecture and cell composition of a Choukroun's platelet-rich fibrin clot and membrane. J Periodontol. 2010;81:546–55. [PubMed] [Google Scholar]
42. Cromack DT, Porras-Reyes B, Mustoe TA. Current concepts in wound healing: Growth factor and macrophage interaction. J Trauma. 1990;30:S129–33. [PubMed] [Google Scholar]
43. Toffler M, Toscano N, Holtzclaw D, Corso MD, Dohan Ehrenfest DM. Introducing Choukroun's platelet rich fibrin (PRF) to the reconstructive surgery milieu. J Implant Adv Clin Dent. 2009;1:21–30. [Google Scholar]
44. Su CY, Kuo YP, Tseng YH, Su CH, Burnouf T. In vitro release of growth factors from platelet-rich fibrin (PRF): A proposal to optimize the clinical applications of PRF. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:56–61. [PubMed] [Google Scholar]
45. Dohan Ehrenfest DM, de Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): A gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors. 2009;27:63–9. [PubMed] [Google Scholar]
46. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part II: Platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e45–50. [PubMed] [Google Scholar]
47. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e56–60. [PubMed]
48. Verma UP, Yadav RK, Dixit M, Gupta A. Platelet-rich fibrin: a paradigm in periodontal therapy–a systematic review. Journal of international society of preventive & community dentistry. 2017 Sep;7(5):227.
49. Chang YC, Zhao JH. Effects of platelet-rich fibrin on human periodontal ligament fibroblasts and application for periodontal infrabony defects. Aust Dent J. 2011;56:365–371. [PubMed]
50. Molly L, Quirynen M, Michiels K, Van Steenberghe D. Comparison between jaw bone augmentation by means of a stiff occlusive titanium membrane or an autologous hip graft: a retrospective clinical assessment. Clin Oral Implants Res. 2006;17:481–487.
51. Simonpieri A, Del Corso M, Vervelle A, Jimbo R, Inchingolo F, Sammartino G, Dohan Ehrenfest DM. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: Bone graft, implant and reconstructive surgery. Curr Pharm Biotechnol. 2012;13:1231–1256. [PubMed]
52. Del Corso M, Toffler M, Dohan Ehrenfest DM. Use of an autologous leukocyte and platelet-rich fibrin (L-PRF) membrane in post-avulsion sites: an overview of Choukroun’s PRF. J Implant Adv Clin Dent. 2010;1:27–35.
53. Simonpieri A, Choukroun J, Del Corso M, Sammartino G, Dohan Ehrenfest DM. Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte- and platelet-rich fibrin as sole grafting material: a six-year experience. Implant Dent. 2011;20:2–12. [PubMed]
54. Mazor Z, Horowitz RA, Del Corso M, Prasad HS, Rohrer MD, Dohan Ehrenfest DM. Sinus floor augmentation with simultaneous implant placement using Choukroun’s platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J Periodontol. 2009;80:2056–2064. [PubMed]
55. Toffler M, Toscano N, Holtzclaw D, Corso MD, Dohan Ehrenfest DM. Introducing Choukroun’s platelet rich fibrin (PRF) to the reconstructive surgery milieu. J Implant Clin Adv Dent. 2009;1:21–30.
56. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:299–303. [PubMed]
57. Yilmaz D, Dogan N, Ozkan A, Sencimen M, Ora BE, Mutlu I. Effect of platelet rich fibrin and beta tricalcium phosphate on bone healing. A histological study in pigs. Acta Cir Bras. 2014;29:59–65. [PubMed]
2. H. Greenwell-Committee on research, science and therapy, American Academy of Periodontology. Position paper: guidelines for periodontal therapy. J Periodontol, 72 (2001), pp. 1624-1628
3. L. Sander, T. Karring. Healing of periodontal lesions in monkeys following the guided tissue regeneration procedure. A histological study. J Clin Periodontol, 22 (1995), pp. 332-337
4. A.K. Deodhar, R.E. Rana. Surgical physiology of wound healing: a review. J Postgrad Med, 43 (1997), pp. 52-56
5. W.V. Giannobile. Periodontal tissue engineering by growth factors. Bone, 19 (Suppl. 1) (1996), pp. 23S-37S
6. D.M. Dohan, J. Choukroun, A. Diss, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate, part I: technological concept and evolution. Oral Surg Oral Med Oral Path Oral Radiol Endod, 101 (2006), pp. E37-E44
7. Ross R, Glomset J, Kariya B, Harker L. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci U S A. 1974;71:1207–1210. [PMC free article] [PubMed] [Google Scholar]
8. Kiran NK, Mukunda KS, Tilak Raj TN. Platelet concentrates: A promising innovation in dentistry. J Dent Sci Res. 2011;2:50–61.
9. Whitmann DH, Berry RL, Green DM. Platelet gel: an alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg. 1997;55:1294–1299. [PubMed]
10. Choukroun J, Adda F, Schoeffler C, Vervelle A. Une opportunité en paro-implantologie: le PRF. Implantodontie. 2000;42:55–62. [Google Scholar]
11. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e37–44. [PubMed]
12. Harrison P. Platelet function analysis. Blood Rev. 2005;19:111–123. [PubMed]
13. Castro HC, Ferreira BLA, Nagashima T, Schueler A, Rueff C, Camisasca D, Moreira G, Scovino G, Borges L, Leal M, Filgueira M, Paschoal P, Bernardo V, Bourguinhon S, Rodrigues CR, Santos DO. Plaquetas: ainda um alvo terapêutico. J Bras Patol Med Lab. 2006;42:321–332. [
14. Fernández-Delgado N, Hernández-Ramírez P, Forrellat-Barrios M. Platelet functional spectrum: from hemostasis to regenerative medicine. Rev Cubana Hematol Inmunol Hemoter. 2012;28:200–216.
15. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e45–50.
16. Garcia VG, Corral I, Bascones-Martínez A. Plasma rico en plaquetas y su utilización en implantología dental. Av Period. 2004;16:81–92.
17. Gupta V, Bains BK, Singh GP, Mathur A, Bains R. Regenerative potential of platelet rich fibrin in dentistry: Literature review. Asian J Oral Health Allied Sci. 2011;1:22–28.
18. Gassling V, Douglas T, Warnke PH, Açil Y, Wiltfang J, Becker ST. Platelet-rich fibrin membranes as scaffolds for periosteal tissue engineering. Clin Oral Implants Res. 2010;21:543–549.
19. Laurens N, Koolwijk P, de Maat MP. Fibrin structure and wound healing. J Thromb Haemost. 2006;4:932–939. [PubMed]
20. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e45–50. [PubMed]
21. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e56–60. [PubMed]
22. Li Q, Pan S, Dangaria SJ, Gopinathan G, Kolokythas A, Chu S, Geng Y, Zhou Y, Luan X. Platelet-rich fibrin promotes periodontal regeneration and enhances alveolar bone augmentation. Biomed Res Int. 2013;2013:638043. [PMC free article] [PubMed]
23. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e51–55. [PubMed]
24. Chang YC, Zhao JH. Effects of platelet-rich fibrin on human periodontal ligament fibroblasts and application for periodontal infrabony defects. Aust Dent J. 2011;56:365–371. [PubMed]
25. Kawase T, Kamiya M, Kobayashi M, Tanaka T, Okuda K, Wolff LF, Yoshie H. The heat-compression technique for the conversion of platelet-rich fibrin preparation to a barrier membrane with a reduced rate of biodegradation. J Biomed Mater Res B Appl Biomater. 2015;103:825–31. [PubMed]
26. Wu CL, Lee SS, Tsai CH, Lu KH, Zhao JH, Chang YC. Platelet-rich fibrin increases cell attachment, proliferation and collagen-related protein expression of human osteoblasts. Aust Dent J. 2012;57:207–212. [PubMed]
27. Saluja H, Dehane V, Mahindra U. Platelet-Rich fibrin: A second generation platelet concentrate and a new friend of oral and maxillofacial surgeons. Ann Maxillofac Surg. 2011;1:53–57. [PMC free article] [PubMed]
28. Bölükbaşı N, Ersanlı S, Keklikoğlu N, Başeğmez C, Ozdemir T. Sinus augmentation with platelet-rich fibrin in combination with bovine bone graft versus bovine bone graft in combination with collagen membrane. J Oral Implantol. 2013 [Epub ahead of print] [PubMed]
29. Joseph VR, Sam G, Amol NV. Clinical evaluation of autologous platelet rich fibrin in horizontal alveolar bony defects. J Clin Diagn Res. 2014;8:ZC43–47. [PMC free article] [PubMed]
30. Kim TH, Kim SH, Sándor GK, Kim YD. Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing. Arch Oral Biol. 2014;59:550–558. [PubMed]
31. Simonpieri A, Del Corso M, Vervelle A, Jimbo R, Inchingolo F, Sammartino G, Dohan Ehrenfest DM. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: Bone graft, implant and reconstructive surgery. Curr Pharm Biotechnol. 2012;13:1231–1256. [PubMed]
32. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: From pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF) Trends Biotechnol. 2009;27:158–67. [PubMed
33. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: From pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF) Trends Biotechnol. 2009;27:158–67. [PubMed]
34. Anitua et al., Sanchez M, Orive G, Andia I. (2007): The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials.28:4551–4560.
35. Dohan et al., Choukroun J, Diss A (2006c): Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part III: Leucocyte activation: A new feature for platelet concentrates? Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology 101(3): e51-e55.
36. Dohan et al., Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J. (2006b): Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod.101:e45–e50.
37. Dohan et al., Del Corso M, Diss A, Mouhyi J, Charrier J-B. (2010): Three-Dimensional Architecture and Cell Composition of a Choukroun’s Platelet-Rich Fibrin Clot and Membrane. J Periodontol 81(4): 546-555.
38. Monitha G, Pavan B, Oza RR. Injectable Platelet-Rich Fibrin-A Revolution in Periodontal Regeneration. Cureus. 2022;14(8).
39. Pavlovic V, Ciric M, Jovanovic V, Trandafilovic M, Stojanovic P. Platelet-rich fibrin: Basics of biological actions and protocol modifications. Open Medicine. 2021 Mar 22;16(1):446-54.
40. Everts PA, Hoffmann J, Weibrich G, Mahoney CB, Schönberger JP, van Zundert A, et al. Differences in platelet growth factor release and leucocyte kinetics during autologous platelet gel formation. Transfus Med. 2006;16:363–8. [PubMed] [Google Scholar]
41. Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB. Three-dimensional architecture and cell composition of a Choukroun's platelet-rich fibrin clot and membrane. J Periodontol. 2010;81:546–55. [PubMed] [Google Scholar]
42. Cromack DT, Porras-Reyes B, Mustoe TA. Current concepts in wound healing: Growth factor and macrophage interaction. J Trauma. 1990;30:S129–33. [PubMed] [Google Scholar]
43. Toffler M, Toscano N, Holtzclaw D, Corso MD, Dohan Ehrenfest DM. Introducing Choukroun's platelet rich fibrin (PRF) to the reconstructive surgery milieu. J Implant Adv Clin Dent. 2009;1:21–30. [Google Scholar]
44. Su CY, Kuo YP, Tseng YH, Su CH, Burnouf T. In vitro release of growth factors from platelet-rich fibrin (PRF): A proposal to optimize the clinical applications of PRF. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:56–61. [PubMed] [Google Scholar]
45. Dohan Ehrenfest DM, de Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): A gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors. 2009;27:63–9. [PubMed] [Google Scholar]
46. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part II: Platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e45–50. [PubMed] [Google Scholar]
47. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e56–60. [PubMed]
48. Verma UP, Yadav RK, Dixit M, Gupta A. Platelet-rich fibrin: a paradigm in periodontal therapy–a systematic review. Journal of international society of preventive & community dentistry. 2017 Sep;7(5):227.
49. Chang YC, Zhao JH. Effects of platelet-rich fibrin on human periodontal ligament fibroblasts and application for periodontal infrabony defects. Aust Dent J. 2011;56:365–371. [PubMed]
50. Molly L, Quirynen M, Michiels K, Van Steenberghe D. Comparison between jaw bone augmentation by means of a stiff occlusive titanium membrane or an autologous hip graft: a retrospective clinical assessment. Clin Oral Implants Res. 2006;17:481–487.
51. Simonpieri A, Del Corso M, Vervelle A, Jimbo R, Inchingolo F, Sammartino G, Dohan Ehrenfest DM. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: Bone graft, implant and reconstructive surgery. Curr Pharm Biotechnol. 2012;13:1231–1256. [PubMed]
52. Del Corso M, Toffler M, Dohan Ehrenfest DM. Use of an autologous leukocyte and platelet-rich fibrin (L-PRF) membrane in post-avulsion sites: an overview of Choukroun’s PRF. J Implant Adv Clin Dent. 2010;1:27–35.
53. Simonpieri A, Choukroun J, Del Corso M, Sammartino G, Dohan Ehrenfest DM. Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte- and platelet-rich fibrin as sole grafting material: a six-year experience. Implant Dent. 2011;20:2–12. [PubMed]
54. Mazor Z, Horowitz RA, Del Corso M, Prasad HS, Rohrer MD, Dohan Ehrenfest DM. Sinus floor augmentation with simultaneous implant placement using Choukroun’s platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J Periodontol. 2009;80:2056–2064. [PubMed]
55. Toffler M, Toscano N, Holtzclaw D, Corso MD, Dohan Ehrenfest DM. Introducing Choukroun’s platelet rich fibrin (PRF) to the reconstructive surgery milieu. J Implant Clin Adv Dent. 2009;1:21–30.
56. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:299–303. [PubMed]
57. Yilmaz D, Dogan N, Ozkan A, Sencimen M, Ora BE, Mutlu I. Effect of platelet rich fibrin and beta tricalcium phosphate on bone healing. A histological study in pigs. Acta Cir Bras. 2014;29:59–65. [PubMed]
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Jul 18, 2023
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Dr. Ruparani Bodduru, Dr. Aiysha Nudrath, Dr. Sushmitha Hari, Dr. Venkata Aruna Mushti, Dr. Deepika Veldurthi, & Dr. Sindhe sai charan. (2023). PRF: EMPOWERING PERIODONTAL REGENERATION FROM WITHIN. Journal of Population Therapeutics and Clinical Pharmacology, 30(17), 268–276. https://doi.org/10.47750/jptcp.2023.30.17.023
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Author Biographies
Dr. Ruparani Bodduru
Professor & HOD, Department of Periodontics and Implantology, MNR Dental College and Hospital, Sangareddy, Telangana, India.
Dr. Aiysha Nudrath
III Year PG student, Department of Periodontics and Implantology, MNR Dental College and Hospital, Sangareddy, Telangana, India.
Dr. Sushmitha Hari
III Year PG student, Department of Periodontics and Implantology, MNR Dental College and Hospital, Sangareddy, Telangana, India.
Dr. Venkata Aruna Mushti
III Year PG student, Department of Periodontics and Implantology, MNR Dental College and Hospital, Sangareddy, Telangana, India.
Dr. Deepika Veldurthi
5Reader, Department of Periodontics and Implantology, MNR Dental College and Hospital, Sangareddy, Telangana, India.
Dr. Sindhe sai charan
Senior Lecturer, Department of Periodontics and Implantology, MNR Dental College and Hospital, Sangareddy, Telangana, India.