USE OF BIOTICS AS PROPHYLAXIS FOR NECROTIZING ENTEROCOLITIS IN PRETERM NEONATES
Main Article Content
Keywords
Necrotizing enterocolitis, preterm neonates, Biotics, probiotics, prebiotics, Prophylactic treatment
Abstract
Necrotizing enterocolitis in premature neonates is a disease that involves inflammation of the intestinal tissue, which leads to perforation of the intestinal wall or necrosis in the mucosa of the digestive tract. This pathological condition prevents the premature infant's body from retaining waste material, so bacteria and other pathogens can enter the bloodstream and cause life-threatening
infections.
Objective: to systematize the suitable scientific evidence on the use of biotics as prophylaxis of Necrotizing Enterocolitis in preterm neonates.
Methodology: This study is a bibliographic review approached under a descriptive - explanatory design and with a qualitative approach, considering the following sources of information: Science Direct, PubMed, Scopus, Lilacs, Cochrane, Redalyc, SciELO and Proquest.
Results: Between strategies to consider to prevent the appearance of necrotizing enterocolitis in preterm neonates is to achieve a functional balance of the microbiotics or intestinal flora. This situation is possible thanks to the administration of probiotics, which are responsible for producing a beneficial effect on the host, and prebiotics, which have the ability to induce the growth of beneficial
microorganisms.
Conclusions: Lactobacillus and Bifidobacterium are the probiotics with the greatest benefit and encouraging results in the prevention and control of severe necrotizing enterocolitis in preterm neonates; while galactooligosaccharides, fructooligosaccharides and oligosaccharides are the prebiotics found naturally in breast milk and contribute to this end.
References
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24. Demestre G, Raspall T. Necrotizing enterocolitis [Internet]. Spanish Association of Pediatrics. 2019 [cited 2023 Apr 16]. p. 405–11. Available from: https://www.aeped.es /sites/ default/files/documentos/42.pdf
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26. Murphy K, Ross P, Ryan A, Dempsey E, Stanton C. Probiotics, Prebiotics, and Synbiotics for the Prevention of Necrotizing Enterocolitis. Front Nutr [Internet]. 2021 Sep 7;8( 12):23–31. Available from: https://www.frontiersin.org/articlen/10.3389/fnut.2021.667188/full
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29. Sharif S, Meader N, Oddie S, Rojas M, McGuire W. Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants. Cochrane Database Syst Rev [Internet]. 2020 Oct 15;2020(10). Available from: http://doi.wiley.com/10. 1002/14651858. CD005496.pub5
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Jul 11, 2023
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Dayanara Geovanna Aldaz Álvarez, Dra. Diana Elizabeth Quizhpi Paredes, & Anita Gabriela Jara Velez. (2023). USE OF BIOTICS AS PROPHYLAXIS FOR NECROTIZING ENTEROCOLITIS IN PRETERM NEONATES. Journal of Population Therapeutics and Clinical Pharmacology, 30(17), 133–145. https://doi.org/10.47750/jptcp.2023.30.17.010
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Author Biographies
Dayanara Geovanna Aldaz Álvarez
Estudiante de la Carrera de Medicina de la Universidad Católica de Cuenca-Ecuador
Dra. Diana Elizabeth Quizhpi Paredes
Msc, Doctora especialista en pediatría. Docente de la Carrera de Medicina de la Universidad Católica de Cuenca-Ecuador