A Morphological Characteristics of Oral Leukoplakia in Riyadh Region KSA

Main Article Content

Keywords

oral leukoplakia, world wide, pre cancerous, facial trauma, nature

Abstract

Abstract


Background


Oral Leukoplakia is a common pre-cancerous condition observed worldwide which often leaves physician in dilemma regarding its benign or malignant nature. Biopsy is the method followed to rule out its malignant nature which is invasive and painful. Patient has to wait for the histopathology report which is usually available after a week, and sometimes even a repeat biopsy is needed.


Methods


Here we did a detailed prospective study on morphological characteristics of 156 patients of oral leukoplakia and compared these with the biopsy outcome. Results were analysed statistically by chi square test using IBM SSPS 28 package and p values were calculated. P values less than 0.05 were taken to be significant.


Results


Smoking and tobacco chewing habits, age of patient, duration, location, margins, tenderness, texture, tendency to peel easily and Induration of Oral Leukoplakia were found to be statistically significant.


Conclusion


Complete morphological description of Oral Leukoplakia provides significant insight to its nature during its first encounter with physician with confirmatory results provided by the biopsy.

Abstract 376 | Pdf Downloads 208

References

1. Scully C. Leukoplakia. Ed: Crispian Scully. Oral and Maxillofacial Medicine. Churchill Livingstone.2013;28(3) p186-191.
2. Carrard VC, Van der Waal I. A Clinical Diagnosis of Oral Leukoplakia; A Guide for Dentists. Med Oral Patol Oral Cir Buccal. 2018;23(1): e59-e64.
3. Chaturvedi AK, Udaltsova N, Engels EA, Katzel JA, Yanik EL, Katki HA, Lingen MW, Silverberg MJ. Oral Leukoplakia and Risk of Progression to Oral Cancer: A Population-Based Cohort Study. J Natl Cancer Inst. 2020;112(10):1047-1054.
4. Napier SS, Speight PM. Natural history of potentially malignant oral lesions and conditions: an overview of the literature. J Oral Pathol Med. 2008;37(1):1–10.
5. Chi AC, Day TA, Neville BW. Oral cavity and oropharyngeal squamous cell carcinoma—an update. CA Cancer J Clin. 2015;65(5):401–421.
6. Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin. 2002;52(4):195–215.
7. Speight PM, Epstein J, Kujan O, et al. Screening for oral cancer-a perspective from the Global Oral Cancer Forum. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(6):680–687.
8. Moyer VA, Force U. Screening for oral cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014;160(1):55–60.
9. Mehanna HM, Rattay T, Smith J, McConkey CC. Treatment and follow-up of oral dysplasia-a systematic review and meta-analysis. Head Neck. 2009;31(12):1600–1609.
10. Warnakulasuriya S, Ariyawardana A. Malignant transformation of oral leukoplakia: a systematic review of observational studies. J Oral Pathol Med. 2016;45(3):155–166.
11. Lee JJ, Hong WK, Hittelman WN, et al. Predicting cancer development in oral leukoplakia: ten years of translational research. Clin Cancer Res. 2000;6(5):1702–1710.
12. William WN Jr, Papadimitrakopoulou V, Lee JJ, et al. Erlotinib and the risk of oral cancer: the Erlotinib Prevention of Oral Cancer (EPOC) randomized clinical trial. JAMA Oncol. 2016;2(2):209–216.
13. Deliverska EG, Petkova M. Management of Oral Leukoplakia-Analysis of the Literature. J of IMAB. 2017;23(1):1495-1504.