Effectiveness of Alpha Lipoic Acid on Postoperative Sequelae on Lower third molar surgery -A Randomized control clinical trial

Main Article Content

Vedha vivigdha A
Santhosh Kumar
Senthil Murugan P
Murugesan
Alladi Sneha

Keywords

Alpha lipoic acid, impaction surgery, healing, dental , age

Abstract

Introduction: Alpha-lipoic acid (ALA) is a compound found in every cell of the human body produced in mitochondria of cells. ALA is powerful antioxidant, and has anti inflammatory and has excellent wound healing property.Many clinical trials has been done to prove the effect of ALA in particular diseases , including diabetic neuropathy, obesity, schizophrenia, alzheimer’s disease, Multiple sclerosis, abnormalities in pregnancy and organ transplantation. Here in this randomized control trial, we are going to check the effectiveness of alpha lipoic acid and compare it with corticosteroids in post operative swelling and healing in third molar surgery.
Aim: To check the effectiveness of alpha lipoic acid in comparison with corticosteroids in swelling and postoperative healing on patients undergoing third molar surgery.
Materials And Methods: The total number of participants in this study is 200 undergoing third molar impaction surgery (Class 1,Class 2 position B- Mesio angular impaction of third molar). Before study,participants were informed about the study by the principal investigator and gave informed written consent.
Case group is 100 patients subjected with 300 Mg of Alpha lipoic acid for 7 days
Control Group is 100 patients given prednisolone 5 mg (wysolone 5) for 3 days  Results: Out of 200 patients, the group which uses alpha lipoic acid has good wound healing when compared to the patient who uses corticosteroids. The inflammation is found to be less in patients who use alpha lipoic acid than corticosteroids.
Conclusion: It can be concluded that steroids can be extremely beneficial, and have serious side effects. ALA has excellent wound healing properties and acts on inflammation similar to corticosteroids but with little or no adverse effects. It’s a good idea to understand the benefits and risks of corticosteroids and replace them with alpha lipoic acid which prevents inflammation and promotes wound healing. 

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