Lycopene And Vitamin E Combination for The Management Of Oral Potentially Malignant Disorders – A Systematic Review

Main Article Content

T.N. Uma Maheswari


Alpha Tocopherol, Oral precancerous lesion, Tomato extract, Leukoplakia, Lichen Planus, Oral submucous fibrosis


Background: Oral potentially malignant disorders (OPMDs) refer to all epithelial lesions and conditions with an increased risk for malignancy. Oral leukoplakia and Oral Submucous Fibrosis are the most common OPMD. Lycopene is a non-provitamin A carotenoid that gives some vegetables and fruits their red color. Vitamin E also called as α-Tocopherol is a non-enzymatic antioxidant. Lycopene and Vitamin E has been proved to be the most potent scavenger of free radicals in various in-vivo and in-vitro studies.
Aim: To assess the effectiveness of lycopene and vitamin E as a combination for the management of Oral Potentially Malignant Disorders.
Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guidelines (PRISMA) was followed. The studies included in this systematic review were identified by a comprehensive search from electronic databases until June 2021 using keyword search and MeSH terms. Risk of bias was assessed using RevMan 5 tool.
Results: The search yielded a total of 306 articles out of which 3 articles were included based on the eligibility criteria. From the 3 included studies, a sample size of 182 patients have proven that lycopene and vitamin E combination can be used in the treatment of oral potentially malignant disorders. Among the three clinical trials, one had low risk of bias and other two had intermediate risk of bias. Based on the Oxford Centre for Evidence level, Grade B recommendation is given.
Conclusion: This systematic review highlights the effectiveness of lycopene and vitamin E combination for the management of oral potentially malignant disorders which can be implicated by the practitioners. The average improvement in mouth opening was 6.575 and 91% patients have shown significant improvement in burning sensation. Based on the current evidence, Lycopene and Vitamin E combination could be considered a safe and effective therapeutic modality in the management of Oral Potentially Malignant Disorders.

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