The Concept of Cancer Translational Research - A Review
Main Article Content
Keywords
Chemotherapy, Oncology, Palliative care, Translational Research
Abstract
The translational research is a multidisciplinary research model which includes the process of discovering the concepts of research by using basic science and applying that knowledge with in the clinical praxis. This model appears to be well constructed and highly systematic and it bridges the concept of basic research and the clinical practice. This research paradigm is one of the basis for developing translational medicine which leads to progression of evidence based medicine to solve the public health issues. In this review, the concept of translational research along with various stages, cancer therapeutics & prevention, the main reasons for inadequate therapeutics along with contemporary and future perspectives were discussed. The terminal goal of translational research is to identify the therapeutic guidelines and regimes which are highly effective with low toxicity. The evolution of biotechnology lead to the development of indisputable chances for ameliorating the ability to diagnose, treat and prevent the neoplasms. Preclinical investigations are undergoing for latest developments and advancements in the molecular biology or molecular targeted therapies which lead to the increased identification of the latest agents for treatment. For the expected quality of oncological practice large variety of molecular tumor characteristics and their supporting models will be helpful for allowing continuous reassessment of human malignancies at molecular level. In conclusion, translational research can be used to improve the public health outcomes and can develop the therapeutic and preventive strategies regarding various diseases or disorders and can provide cost benefit health care analysis. Thus, consistent efforts in translational research stimulate the logical and reasonable inventions in the field of multidisciplinary cancer research in future.
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2. Mehic B. Translational research in medicine. Bosn J Basic Med Sci. 2011 May;11(2):73.
3. Gonzales R, Handley MA, Ackerman S et al. A framework for training health professionals in implementation and dissemination science. Acad Med. 2012; 87:271-8.
4. Dilmore TC, Moore DW, Bjork Z. Developing a competency-based educational structure within
clinical and translational science. Clin Transl Sci. 2013; 6:98–102.
5. Munoz DA, Nembhard HB, Kraschnewski JL. Quantifying complexity in translational research: an integrated approach. Int J Health Care Qual Assur. 2014; 27:760–76.
6. Griswold-Theodorson S, Ponnuru S, Dong C et al. Beyond the simulation laboratory: A realist synthesis review of clinical outcomes of simulation-based mastery learning. Acad Med. 2015; 90:1553- 60.
7. Hiss RG. USA: Natcher Conference Center, National Institutes of Health, Bethesda, Maryland; 2004. Fundamental issues in translational research. Translational research—two phases of a continuum. In: From clinical trials to community: the science of translating diabetes and obesity research; pp. 11–4.
8. Peyraud F, Cousin S, Italiano A. CSF-1R Inhibitor Development: Current Clinical Status. Curr Oncol Rep. 2017; 19:70.
9. Zarbin M. What Constitutes Translational Research? Implications for the Scope of Translational Vision Science and Technology. Transl Vis Sci Technol. 2020 Jul 14; 9(8):22.
10. Vukotich CJ. Jr. Challenges of T3 and T4 translational research. J Res Pract. 2016;12:P2.
11. Khoury MJ, Gwinn M, Yoon PW et al. The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genet Med. 2007; 9: 665–74.
12. Westfall JM, Mold J, Fagnan L. Practice-based research–“Blue Highways” on the NIH roadmap. JAMA. 2007; 297:403–6.
13. Fort DG, Herr TM, Shaw PL et al. Mapping the evolving definitions of translational research. J Clin Transl Sci. 2017;1: 60–6.
14. Ringborg U. Translational cancer research - a coherent cancer research continuum. Mol Oncol. 2019 Mar;13(3):517-520.
15. McGartland Rubio D, Schoenbaum EE, Lee LS et al. Defining translational research: implications for training. Acad Med. 2010; 85: 470–5.
16. Calvo F, Apolone G, Baumann M et al. Cancer Core Europe: a European cancer research alliance realizing a research infrastructure with critical mass and programmatic approach to cure cancer in the 21st century. Eur J Cancer. 2018; 103:155–9.
17. Forman D, Bauld L, Bonanni B et al. Time for a European initiative for research to prevent cancer: a manifesto for Cancer Prevention Europe (CPE). J Cancer Policy. 2018; 17:15–23.
18. Lacombe D, Bogaerts J, Tombal B et al. Late translational research: putting forward a new model for developing new anti-cancer treatments that addresses the needs of patients and society. Mol Oncol. 2019; 13: 558–66.
19. Jonsson B and Sullivan R. Mission-oriented € translational cancer research – health economics. Mol Oncol. 2019; 13: 636– 47.
20. Lagergren P, Schandl A, Aaronson NK et al. Cancer survivorship: an integral part of Europe’s research agenda. Mol Oncol. 2019; 13:624-35.
21. Oberst S. Bridging research and clinical care – the comprehensive cancer centre. Mol Oncol. 2019; 13:614–18.
22. Goldblatt EM, Lee WH. From bench to bedside: the growing use of translational research in cancer medicine. Am J Transl Res. 2010 Jan 1; 2(1):1-18.
23. Bernier J, Hall EJ et al. Radiation oncology: A century of achievements. Nat Rev Cancer. 2004; 4:737- 47.
24. Haffty BG, Kim JH et al. Concurrent chemo-radiation in the conservative management of breast cancer. Int J Radiat Oncol Biol Phys.2006; 66:1306-12.
25. Hirbe A, Morgan EA, Uluçkan O et al. Skeletal Complications of Breast Cancer Therapies. Clin Cancer Res. 2006; 12:6309-14.
26. Munshi A. Breast cancer radiotherapy and cardiac risk: The 15-year paradox! J Cancer Res Ther. 2007; 3:190-2.
27. Torres-Roca JF and Stevens CW. Predicting Response to Clinical Radiotherapy: Past, Present, and Future Directions. Cancer Control. 2008; 15:151-6.
28. Sofou S. Radionuclide carriers for targeting of cancer. Int J Nanomed. 2008; 3:181-99.
29. Van Meerbeeck JP, Meersschout S, de Pauw R et al. Modern Radiotherapy as Part of Combined Modality Treatment in Locally Advanced Non-Small Cell Lunch Cancer: Present Status and Future Prospects. The Oncologist. 2008; 13:700-8.
30. Scott RB. Cancer Chemotherapy- The First Twenty-five Years. British Med J. 1970; 4:259- 65.
31. Devita VT and Chu E. A History of Cancer Chemotherapy. Cancer Res. 2008; 68:8643- 53.
32. Saijo N, Nishio K, Tamura T. Translational and clinical studies of target-based cancer therapy. Int J Clin Oncol. 2003; 8:187-92.
33. Fabian MA, Biggs WH, Treiber DK. A small molecule-kinase interaction map for clinical kinase inhibitors. Nature Biotech. 2005; 23:329-36.
34. Voldborg BR, Damstrup L, Spang-Thomson M et al. Epidermal Growth Factor Receptor (EGFR) and EGFR mutations, function, and possible role in clinical trials. Ann Onc. 1997; 8:1197-1206.
35. Nicholson RI, Gee JM, Harper ME. EGFR and cancer prognosis. Eur J Cancer. 2001; 37:9-15.
36. Slamon DJ, Leyland-Jones B, Shak S et al. Use of Chemotherapy Plus a Monoclonal Antibody Against HER2 for Metastatic Breast Cancer that Overexpresses HER2. N Engl J Med. 2001; 344:783-92.
37. Ross JS, Fletcher AJ, Linette GP et al. The HER-2/neu Gene and Protein in Breast Cancer 2003: Biomarker and Target of Therapy. The Oncologist. 2003; 8:307-25.
38. Bareschino MA, Schettino C, Troiani T et al. Erlotinib in cancer treatment. Ann Onc. 2007; 18:35-41.
39. Gridelli C, Bareschino MA, Schettino C et al. Erlotinib in Non-Small Cell Lung Cancer Treatment: Current Status and Future Development. The Oncologist. 2007; 12:840-9.
40. Ono M and Kuwano M. Molecular Mechanisms of Epidermal Growth Factor Receptor (EGFR) Activation and Response to Gefitinib and Other EGFR-Targeting Drugs. Clin Cancer Res. 2006; 12:7242-51.
41. Ross JS, Fletcher JA, Bloom KJ et al. Targeted Therapy in Breast Cancer: the HER2/neu gene and protein. Mol Cell Proteomics. 2004; 3.4:379-98.
42. Hudis CA. Trastuzumab-Mechanism of Action and Use in Clinical Practice. N Eng J Med. 2007; 357:39-51.
43. Steeghs N, Nortier JWR, Gelderblom H. Small Molecule Tyrosine Kinase Inhibitors in the Treatment of Solid Tumors: And Update of Recent Developments. Ann Surg Onc. 2006; 14:942-53.
44. Moy B, Kirkpatrick P, Kar S, Goss P. Lapatinib. Nat Rev Drug Discov. 2007; 6:431-2.
45. Hayes DF, Miller K, Sledge G. Angiogenesis as targeted breast cancer therapy. The Breast. 2007; 16:S17-9.
46. Salter JT and Miller KD. Antiangiogenic Agents in Breast Cancer. Cancer Investigation. 2007; 25:518-26.
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May 5, 2023
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S. Ramachandran, Ramam Sripada, Lakshmi Himaja Bandaru, & P. Himasree. (2023). The Concept of Cancer Translational Research - A Review. Journal of Population Therapeutics and Clinical Pharmacology, 30(9), 258–270. https://doi.org/10.53555/jptcp.v30i9.1753
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